Revisiting the World ’s Strictest COVID-19 Lockdown:
Formidable Mental Health Challenges
Discussion Lockdown duration significantly affects mental health, with
longer lockdown duration being associated with worse mental health status. The
relationship between lockdown and mental health should not be neglected in case
of lockdown in response to future pandemics. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 12, 2023 Category: Psychiatry Authors: Guan, Beier Li, Ruihua Huang, Chuanning Du, Jiang Zhao, Min Liu, Shuyan Tags: Original Paper Source Type: research
High Prescribing and State-Level Variation in Z-Drug Use Among
Medicare Patients
Discussion Contrary to the Beers criteria, Z-drugs are prescribed to older
adults at high rates. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 7, 2023 Category: Psychiatry Authors: Anderson, Kaitlin E. Gifeisman, Rachel I. Basting, James L. Harris, Donovan J. Rajan, Antonica R. McCall, Kenneth L. Piper, Brian J. Tags: Original Paper Source Type: research
Establishing Core Symptoms of Acute Serotonin Reuptake Inhibitor
Withdrawal: Results from an International Survey of Online Peer-Support
Communities
Conclusion Nearly all surveyed subjects reported worsening either of
dizziness, brain zaps, irritability/agitation, or
anxiety/nervousness in acute withdrawal. A screening test incorporating
these four core symptoms may be sufficiently sensitive to rule out SRI
withdrawal and may be valuable in clinical and research settings. Incorporating
withdrawal symptom severity may further enhance specificity. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 30, 2023 Category: Psychiatry Authors: Shapiro, Bryan Kramer, Eric Khoury, Dina Preda, Adrian Tags: Original Paper Source Type: research
GABAergic Effects of Etifoxine and Alprazolam Assessed by Double
Pulse TMS
This study indicated a favorable side effect profile of
etifoxine in healthy volunteers. Moreover, it revealed differential GABA-related
effects on neuromuscular function by means of TMS. The side effects and TMS
profile of etifoxine are compatible with the involvement of neurosteroidogenesis
and a predominant α3 subunit modulation compared to alprazolam. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 23, 2023 Category: Psychiatry Authors: Riebel, Marco von Pappenheim, Benedikt Kanig, Carolina Nothdurfter, Caroline Wetter, Thomas C. Rupprecht, Rainer Schwarzbach, Jens Tags: Original Paper Source Type: research
„Peter Müller Preis für Forschung im Bereich Schizophrenie“ in Höhe von 5.000€
Pharmacopsychiatry 2023; 56: 127-127 DOI: 10.1055/a-2079-9476 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 15, 2023 Category: Psychiatry Tags: Ausschreibung Peter M üller Preis für Forschung im
Bereich Schizophrenie Source Type: research
„AGNP-Preis für Forschung in der Psychopharmakologie“ in Höhe von 5.000 €
Pharmacopsychiatry 2023; 56: 126-126 DOI: 10.1055/a-2079-9272Wohl kaum eine andere Arzneimittelgruppe hat durch ihre Einführung so immense
therapeutische Möglichkeiten eröffnet wie die Psychopharmaka. In den
über 60 Jahren seit ihrer Entdeckung haben sie vielen psychisch Kranken
entscheidend geholfen. Heute sind sie aus der Therapie psychischer Erkrankungen
nicht mehr wegzudenken. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 15, 2023 Category: Psychiatry Tags: Ausschreibung AGNP-Preis f ür Forschung in der Psychopharmakologie Source Type: research
The Role of Mood Stabilizers in Children and Adolescents with
Anorexia Nervosa: A 1-year Follow-Up, Propensity Score-Matched
Study
Conclusions This propensity score-matched study expands on the scant
existing evidence of the use and side effects of MS in children and adolescents
with AN. These results should be assessed in wider longitudinal samples. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 15, 2023 Category: Psychiatry Authors: Pruccoli, Jacopo Parmeggiani, Antonia Tags: Original Paper Source Type: research
Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study
Circadian Rhythmicity in Psychiatric Disorders
Pharmacopsychiatry 2023; 56: 87-100 DOI: 10.1055/a-1147-1552A number of psychiatric disorders are defined by persistent or recurrent
sleep-wake disturbances alongside disruptions in circadian rhythm and
altered clock gene expression. Circadian rhythms are present not only in the
hypothalamic suprachiasmatic nucleus but also in peripheral tissues. In this
respect, cultures of human derived dermal fibroblasts may serve as a
promising new tool to investigate cellular and molecular mechanisms
underlying the pathophysiology of mental illness. In this articl...
Source: Pharmacopsychiatry - May 15, 2023 Category: Psychiatry Authors: Palm, Denise Uzoni, Adriana Kronenberg, Golo Thome, Johannes Faltraco, Frank Tags: Review Source Type: research
The Role of Circadian Rhythmicity and CLOCK Genes in
Psychiatry
Pharmacopsychiatry 2023; 56: 85-86 DOI: 10.1055/a-2078-4905Circadian rhythms are biological oscillations, that perpetuate themselves even in the
absence of “zeitgebers” (external time cues), with a period of
approximately 24 hours. The master pacemaker is the suprachiasmatic nucleus
(SCN) of the hypothalamus. The SCN is entrained by environmental factors,
particularly light, to the 24-hour light-dark cycle by the Earth’s rotation.
Peripheral circadian oscillators, located in multiple cell types and tissues, are
controlled by signals arising from the SCN and from the e...
Source: Pharmacopsychiatry - May 15, 2023 Category: Psychiatry Authors: Palm, Denise Thome, Johannes Tags: Editorial Source Type: research
Effects of Anesthesia Changes During Maintenance ECT: A Longitudinal
Comparison of Seizure Quality Under Anesthesia Using Propofol/Esketamine
Versus Methohexital
Discussion Although to what extent these parameters correlate with the
therapeutic effectiveness remains ambiguous, a decision for or against a
particular anesthetic could be considered if a specific SQ parameter needs
optimization. However, no general superiority for one specific substance or
combination was found in this study. In the next step, anesthetic effects on
treatment response and tolerability should be focused on. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full ...
Source: Pharmacopsychiatry - April 28, 2023 Category: Psychiatry Authors: Methfessel, Isabel Zilles-Wegner, David Kunze-Szikszay, Nils Belz, Michael Tags: Original Paper Source Type: research
Low Escitalopram Concentrations in Patients with Depression predict
Treatment Failure: A Naturalistic Retrospective Study
Discussion Medication switch is a valuable objective surrogate marker to
assess treatment effects under real-world conditions. Of note, treatment
discontinuation is not always a cause of insufficient response but may also be
related to other factors such as medication side effects. TDM might not only be
useful in addressing these issues but titrating drug concentrations into the
currently recommended reference range for escitalopram will also increase
response in non-responders and avoid treatment failure in underdosed
patients. [...] Georg Thieme Verlag...
Source: Pharmacopsychiatry - March 21, 2023 Category: Psychiatry Authors: Hart, Xenia M. Amann, Friederike Brand, Jonas Eichentopf, Luzie Gr ünder, Gerhard Tags: Original Paper Source Type: research
DNA Methylation of POMC and NR3C1-1F and Its
Implication in Major Depressive Disorder and Electroconvulsive
Therapy
Discussion Our findings indicate that both genes might play a role in the
chronification of depression and NR3C1 may be relevant for ECT response
prediction. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 21, 2023 Category: Psychiatry Authors: Maier, Hannah B. Moschny, Nicole Eberle, Franziska Jahn, Kirsten Folsche, Thorsten Sch ülke, Rasmus Bleich, Stefan Frieling, Helge Neyazi, Alexandra Tags: Original Paper Source Type: research
The Mini-TRH Test
Pharmacopsychiatry DOI: 10.1055/a-1978-8348Thyrotropin-releasing hormone (TRH), at doses lower than those needed to
stimulate prolactin secretion directly, can almost completely antagonize
dopamine inhibition of prolactin release. In normal men, prolactin increases
15 min following an i. v. bolus of 12.5 µg TRH
(the mini-TRH test), but not the maximal prolactin response to TRH or basal
prolactin, positively correlated with prolactin response to haloperidol and
negatively with 24-h urinary excretion of homovanillic acid (HVA). These results
suggest...
Source: Pharmacopsychiatry - December 9, 2022 Category: Psychiatry Authors: Spoov, Johan Tags: Review Source Type: research
Dexmedetomidine in Psychiatry: Repurposing of its Fast-Acting
Anxiolytic, Analgesic and Sleep Modulating Properties
In conclusion, dexmedetomidine is a promising candidate for an experimental
treatment targeting stress-related pathologies common in neuropsychiatric
disorders such as depression, anxiety disorders, and posttraumatic stress
disorder. First small proof-of-concept studies and then larger controlled
clinical trials are warranted in psychiatric populations to test the feasibility
and efficacy of dexmedetomidine in these conditions. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Ful...
Source: Pharmacopsychiatry - November 16, 2022 Category: Psychiatry Authors: Bosch, Oliver G. Dornbierer, Dario A. Bavato, Francesco Quednow, Boris B. Landolt, Hans-Peter Seifritz, Erich Tags: Review Source Type: research
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Pharmacopsychiatry 2022; 06 Article in Thieme eJournals: Table of contents | Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 8, 2022 Category: Psychiatry Source Type: research
