Consider Role of Glutamatergic Habenula-projecting Globus Pallidus in OCD
Pharmacopsychiatry DOI: 10.1055/a-0835-6447Recently, in a review article in this journal, Vlček and colleagues described the putative role played by the glutamatergic system in obsessive-compulsive disorder (OCD) and how this might explain the effects of certain treatments. They describe a neuroanatomical model, which includes a specific role of the amygdala-hippocampus complex (AHC) and would complete the classic cortico-striatal-thalamo-cortical (CSTC) mechanism of OCD. The role of the AHC can perhaps be better understood when considering its ancient relationship to the rest of the forebrain of mammals. This leads to di...
Source: Pharmacopsychiatry - February 4, 2019 Category: Psychiatry Authors: Loonen, Anton J.M. Ivanova, Svetlana A. Tags: Letter to the Editor Source Type: research
Correlation Between Violence and Antipsychotic Dosage in Schizophrenia: A Secondary Analysis of The Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) Dataset
Discussion Violence in schizophrenia is associated with poor illness course. Further studies focusing on violence in younger non-white individuals are warranted. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 22, 2019 Category: Psychiatry Authors: Tasmim, Samia Kolla, Nathan J. Dada, Oluwagbenga Bani-Fatemi, Ali De Luca, Vincenzo Tags: Original Paper Source Type: research
A Big Thank You to Our Reviewers in the Past Year!
Pharmacopsychiatry 2019; 52: 5-6 DOI: 10.1055/a-0821-0656 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 10, 2019 Category: Psychiatry Tags: Acknowledgment to Reviewers Source Type: research
The Efficacy of Tiapride and Carbamazepine Combination Therapy in Reducing Alcohol Withdrawal Symptoms: A Systematic Review and Meta-Analysis
Pharmacopsychiatry DOI: 10.1055/a-0795-3689The combination of tiapride (TIA) and carbamazepine (CBZ) as an alternative treatment option to benzodiazepines and clomethiazole has been investigated by several investigations. We performed a systematic review and meta-analysis to further explore the efficacy of this combination in order to render more definite answers whether this combination can be recommendable in the clinical practice. We systematically searched electronic databases including PubMed (MEDLINE), EMBASE, OVID, Cochrane, Google Scholar, and Scopus for human studies. Statistical homogeneity was checked by χ2 tes...
Source: Pharmacopsychiatry - December 6, 2018 Category: Psychiatry Authors: Latifi, Sahar Messer, Thomas Tags: Review Source Type: research
Obituary for Professor Hinderk Meiners Emrich, MD PhD
Pharmacopsychiatry DOI: 10.1055/a-0760-2100 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 3, 2018 Category: Psychiatry Authors: Leweke, F. Markus Bleich, Stefan Schneider, Udo Tags: Obituary Source Type: research
The Associations Between CYP2D6 Metabolizer Status and Pharmacokinetics and Clinical Outcomes of Venlafaxine: A Systematic Review and Meta-Analysis
Conclusions CYP2D6 metabolizer status had significant influence on venlafaxine pharmacokinetics, but insufficient evidence demonstrated that CYP2D6 metabolizer status was associated with its therapeutic effects and overall rate of adverse events, which provided further evidence regarding the relationship between CYP2D6 metabolizer status and venlafaxine. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 28, 2018 Category: Psychiatry Authors: Lin, Xiao-Qian Wang, Ping Cai, Wen-Ke Xu, Gui-Li Yang, Mei Zhou, Meng-Di Sun, Mei He, Fang He, Gong-Hao Tags: Original Paper Source Type: research
Studies of Half-Lives of Long-Acting Antipsychotics are Needed
Pharmacopsychiatry DOI: 10.1055/a-0755-7692 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 22, 2018 Category: Psychiatry Authors: Schoretsanitis, Georgios Villasante-Tezanos, Alejandro G. de Leon, Jose Tags: Letter to the Editor Source Type: research
Comparing Schizophrenia Patients With a Predicted High/Low Risk of Nonresponse Receiving Treatment with Ziprasidone and Haloperidol: A Randomized-Controlled Study
Discussion An alarmingly high number of patients were at high risk of nonresponse to antipsychotic treatment. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 20, 2018 Category: Psychiatry Authors: Schennach, Rebecca Riedel, Michael Spellmann, Ilja Musil, Richard Obermeier, Michael J äger, Markus Bottlender, Roland Schmauss, Max Laux, Gerd M öller, Hans-Jürgen Tags: Original Paper Source Type: research
Augmentation of Pharmacotherapy by Sleep Deprivation with Sleep Phase Advance in Treatment-Resistant Depression
Discussion Our preliminary study demonstrated the efficacy of pharmacotherapy augmentation by TSD and SPA in half of the patients with TRD. The main biochemical factors related to clinical response included status of cortisol and increase in IL-10 and IL-1β levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 10, 2018 Category: Psychiatry Authors: Kurczewska, Ewa Ferensztajn-Rochowiak, Ewa Jasi ńska-Mikołajczyk, Anna Ch łopocka-Woźniak, Maria Rybakowski, J. K. Tags: Original Paper Source Type: research
Efficacy of Add-on Pregabalin in the Treatment of Patients with Generalized Anxiety Disorder and Unipolar Major Depression With an Early Nonresponse to Escitalopram: A Double-Blind Placebo-Controlled Study
This study tests the efficacy of pregabalin versus placebo as adjunctive treatment in patients with generalized anxiety disorder (GAD) comorbid with unipolar major depression (UMD) and with an early nonresponse to escitalopram.
Methods This is a double-blind, placebo-controlled 8-week add-on study of pregabalin, 75–600 mg/day (n=31) versus placebo (n=29) on open-label escitalopram in outpatients meeting the DSM-IV-TR criteria for GAD and UMD. The main outcome measures were change from baseline to endpoint in total STAI-S, Trail-Making Test B (TMT-B) and the Center of Epidemiological Studies Depression Scale (CES-D). Al...
Source: Pharmacopsychiatry - August 31, 2018 Category: Psychiatry Authors: Fountoulakis, Konstantinos N Karavelas, Vangelis Moysidou, Stefania Mavridis, Dimitris Pastiadis, Konstantinos Petalidou, Nicole Nimatoudis, Ioannis Kasper, Siegfried Tags: Original Paper Source Type: research
Treatment Options for Insomnia in Schizophrenia: A Systematic Review
Conclusions Despite a very limited number of specific studies on this matter, all 4 studies have shown good benefit/risk ratios and reviewed options—melatonin, paliperidone, and eszopiclone—might represent valid options for residual insomnia in schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 30, 2018 Category: Psychiatry Authors: Oliveira, Pedro Coroa, Manuel Madeira, Nuno Tags: Review Source Type: research
Molecular Signatures of Lithium Treatment: Current Knowledge
Pharmacopsychiatry DOI: 10.1055/a-0650-4820Lithium (Li) is the key mood stabilizer in the prevention of mood recurrences and suicide in bipolar disorders. However, only one-third of patients become asymptomatic with Li treatment, and to date, no clinical markers can predict this response variability. Li is a multitargeting drug, complicating an understanding of its mechanisms of action. The present article reviews Li’s various biological effects, including those obtained in transcriptomic and epigenetic studies, in both humans and animal models. A molecular signature of the therapeutic response to Li is urgently required...
Source: Pharmacopsychiatry - July 30, 2018 Category: Psychiatry Authors: Bellivier, Frank Marie-Claire, Cynthia Tags: Review Source Type: research
Algorithms For Treatment of Major Depressive Disorder: Efficacy and Cost-Effectiveness
In conclusion, research in MDD revealed that systematic and structured treatment procedures, the diligent assessment of response at critical decision points, and timely dose and treatment type adjustments make the substantial difference in treatment outcomes between algorithm-guided treatment and treatment as usual. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 9, 2018 Category: Psychiatry Authors: Bauer, Michael Rush, A. John Ricken, Roland Pilhatsch, Maximilian Adli, Mazda Tags: Review Source Type: research
70 Years of Research and 50 Years of Lithium Clinics: From Serendipity to Gold Standard in Mood Disorders
Pharmacopsychiatry DOI: 10.1055/a-0651-8119 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 9, 2018 Category: Psychiatry Authors: Bauer, Michael Tags: Editorial Source Type: research
A Novel Study Design to Systematically Explore the Impact of Trial Methodology on Psychopharmacological Treatment Outcome in Patients with Depression
Discussion The results of the proposed study design may have substantial consequences when it comes to how to best interpret the results of traditional randomized, double-blind, placebo-controlled trials in the acute treatment of major depressive disorder. Furthermore, they may lead to the implementation of new study designs that may be more suitable for assessing the effectiveness of new antidepressant compounds in everyday clinical practice. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 5, 2018 Category: Psychiatry Authors: Severus, Emanuel Sauer, Cathrin Bauer, Michael Ostacher, Michael Anghelescu, Ion-George Tags: Original Paper Source Type: research
