Factors Associated with Medication Adherence to Long-Acting
Injectable Antipsychotics: Results from the STAR Network Depot
Study
Discussion Our findings suggest that adherence to LAI is principally
related to attitude toward medication and traits of
suspiciousness/hostility. Quality of patient-clinician relationship and
tailored psychoeducational strategies may positively affect adherence in people
undergoing psychopharmacological treatment, including LAI. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - April 25, 2022 Category: Psychiatry Authors: Aguglia, Andrea Fusar-Poli, Laura Natale, Antimo Amerio, Andrea Espa, Irene Villa, Veronica Martinotti, Giovanni Carr à, Giuseppe Bartoli, Francesco D ’Agostino, Armando Serafini, Gianluca Amore, Mario Aguglia, Eugenio Ostuzzi, Giovanni Barbui, Corrado Tags: Original Paper Source Type: research
Morphological Representation of C1q in the Aging Central Nervous
System
Discussion The applied free-floating approach is suitable for C1q
immunofluorescence imaging. The consistent colocalization of the complement
protein C1q with β-amyloid plaques may reflect an activated immune
response, whereas the accumulation of C1q around neuronal structures such as
somata and dendrites is still a matter of debate. Intriguingly, C1q surrounds
those structures in older brains of both wild-type and ArcAβ mice. Our
results also indicate an involvement of C1q in neurophysiological and
neurodegenerative processes. [...] Georg Thieme Verla...
Source: Pharmacopsychiatry - March 16, 2022 Category: Psychiatry Authors: Rupprecht, Christian Sarker, Rim S. J. Rammes, Gerhard Tags: Original Paper Source Type: research
Serious Adverse Drug Reactions in Children and Adolescents Treated
On- and Off-Label with Antidepressants and Antipsychotics in Clinical
Practice
Conclusion Off-label use of antidepressants and antipsychotics in youth
was not a risk factor for the occurrence of serious ADRs in a closely monitored
clinical setting. Results from large naturalistic trials like ours can
contribute to bridging the gap between knowledge from randomized controlled
trials and real-world clinical settings. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 7, 2022 Category: Psychiatry Authors: Egberts, Karin M. Gerlach, Manfred Correll, Christoph U. Plener, Paul L. Malzahn, Uwe Heuschmann, Peter Unterecker, Stefan Scherf-Clavel, Maike Rock, Hans Antony, Gisela Briegel, Wolfgang Fleischhaker, Christian H äge, Alexander Hellenschmidt, Tobias Img Tags: Original Paper Source Type: research
Drug Combinations for Mood Disorders and Physical Comorbidities That
Need Attention: A Cross-Sectional National Database Survey
This study investigated combined prescriptions of drugs for
mood disorders and physical comorbidities that need special attention in the
light of frequent physical comorbidities in patients with mood disorders.
Methods We used the claims sampling data of 581,990 outpatients in January
2015 from the National Database of Health Insurance Claims and Specific Health
Checkups of Japan. Fisher’s exact test was performed to compare the
prescription rates of non-steroidal anti-inflammatory drugs (NSAIDs),
loop/thiazide diuretics, angiotensin-converting enzyme inhib...
Source: Pharmacopsychiatry - February 4, 2022 Category: Psychiatry Authors: Kuramochi, Shin Yatomi, Taisuke Uchida, Takahito Takeuchi, Hiroyoshi Mimura, Masaru Uchida, Hiroyuki Tags: Original Paper Source Type: research
Classic Psychedelic Drugs: Update on Biological
Mechanisms
Pharmacopsychiatry DOI: 10.1055/a-1721-2914Renewed interest in the effects of psychedelics in the treatment of psychiatric
disorders warrants a better understanding of the neurobiological mechanisms
underlying the effects of these substances. During the past two decades,
state-of-the-art studies of animals and humans have yielded new important
insights into the molecular, cellular, and systems-level actions of psychedelic
drugs. These efforts have revealed that psychedelics affect primarily
serotonergic receptor subtypes located in cortico-thalamic and cortico-cor...
Source: Pharmacopsychiatry - January 25, 2022 Category: Psychiatry Authors: Vollenweider, Franz X. Smallridge, John W. Tags: Review Source Type: research
Neuropsychiatric Drugs Against COVID-19: What is the Clinical
Evidence?
Pharmacopsychiatry 2022; 55: 7-15 DOI: 10.1055/a-1717-2381Since the beginning of the coronavirus disease (COVID)-19 pandemic, the need for
effective treatments for COVID-19 led to the idea of
“repurposing” drugs for antiviral treatment. Several
antipsychotics and antidepressants have been tested for in vitro activity
against the severe acute respiratory syndrome coronavirus 2. Chlorpromazine,
other phenothiazine antipsychotics, and the antidepressant fluoxetine were found
to be rather potent in these studies. However, whether effective plasma
concent...
Source: Pharmacopsychiatry - January 25, 2022 Category: Psychiatry Authors: Mueller, Juliane K. Riederer, Peter M üller, Walter E. Tags: Review Source Type: research
Covid-19: Contributions from Psychopharmacology
Pharmacopsychiatry 2022; 55: 5-6 DOI: 10.1055/a-1720-8855The COVID-19 pandemic is causing a major burden on personal health, healthcare
systems and the global economy. For the last two years the COVID-19 pandemic has
dramatically changed our lives in many personal and professional areas. For millions
of us, due to infection rates, but also to protection measures such as lockdowns the
corona pandemic has significantly changed the way we work, how we live, and how we
interact with technology. In addition to the development of effective vaccines,
anti-viral and anti-...
Source: Pharmacopsychiatry - January 25, 2022 Category: Psychiatry Authors: Bauer, Michael Juckel, Georg Tags: Editorial Source Type: research
Correction: An International Adult Guideline for Making Clozapine Titration Safer
by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine
Levels
Pharmacopsychiatry DOI: 10.1055/a-1737-1527 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 20, 2022 Category: Psychiatry Authors: de Leon, Jose Schoretsanitis, Georgios Smith, Robert L. Molden, Espen Solismaa, Anssi Sepp älä, Niko Kope ček, Miloslav Švancer, Patrik Olmos, Ismael Ricciardi, Carina Iglesias-Garcia, Celso Iglesias-Alonso, Ana Spina, Edoardo Ruan, Can-Jun Wang, Chua Tags: Erratum Source Type: research
Novel Antidepressants in the Pipeline (Phase II and III): A
Systematic Review of the US Clinical Trials Registry
Discussion These new compounds with novel mechanisms of action are
expected to provide a greater variety of treatment options for depression if
preliminary positive results are confirmed. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 19, 2022 Category: Psychiatry Authors: Sakurai, Hitoshi Yonezawa, Kengo Tani, Hideaki Mimura, Masaru Bauer, Michael Uchida, Hiroyuki Tags: Review Source Type: research
Rationale, Mission and Vision for a National Centre of Affective
Disorders in Germany
Pharmacopsychiatry DOI: 10.1055/a-1697-5854Affective disorders are common, complex disorders representing one of the major
challenges to global health in the 21st century. To mitigate the burden of
disease, substantial public health efforts need to be undertaken since research
on the causes and adequate treatment requires multidisciplinary approaches.
These should integrate translational, and clinical research, aided by
technological advancements in collecting and analysing comprehensive data. Here
we present the rationale, concept, mission and vision of the recen...
Source: Pharmacopsychiatry - December 17, 2021 Category: Psychiatry Authors: Reif, Andreas Baune, Bernhard T. Deckert, J ürgen Juckel, Georg Kittel-Schneider, Sarah Kircher, Tilo Kornhuber, Johannes Rupprecht, Rainer Bauer, Michael Tags: Review Source Type: research
An International Adult Guideline for Making Clozapine Titration Safer
by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine
Levels
Pharmacopsychiatry DOI: 10.1055/a-1625-6388This international guideline proposes improving clozapine package inserts
worldwide by using ancestry-based dosing and titration. Adverse drug reaction
(ADR) databases suggest that clozapine is the third most toxic drug in the
United States (US), and it produces four times higher worldwide pneumonia
mortality than that by agranulocytosis or myocarditis. For trough steady-state
clozapine serum concentrations, the therapeutic reference range is narrow, from
350 to 600 ng/mL with the potential for toxicity and ADRs as
...
Source: Pharmacopsychiatry - December 15, 2021 Category: Psychiatry Authors: de Leon, Jose Schoretsanitis, Georgios Smith, Robert L. Molden, Espen Solismaa, Anssi Sepp älä, Niko Kope ček, Miloslav Švancer, Patrik Olmos, Ismael Ricciardi, Carina Iglesias-Garcia, Celso Iglesias-Alonso, Ana Spina, Edoardo Ruan, Can-Jun Wang, Chua Tags: Review Source Type: research
Opportunities for Drug Repurposing of Serotonin Reuptake Inhibitors:
Potential Uses in Inflammation, Infection, Cancer, Neuroprotection, and
Alzheimer ’s Disease Prevention
Pharmacopsychiatry DOI: 10.1055/a-1686-9620Serotonin reuptake inhibitors (SRIs) are safe and widely used for a variety of
indications including depressive disorders, anxiety, and chronic pain. Besides
inhibiting the serotonin transporter, these medications have broad-spectrum
properties in many systems. Their roles have been studied in cancer,
Alzheimer’s disease, and infectious processes. The COVID-19 pandemic
highlighted the importance of drug repurposing of medications already in use. We
conducted a narrative review of current evidence and ongoing research on...
Source: Pharmacopsychiatry - December 7, 2021 Category: Psychiatry Authors: Nykamp, Madeline J. Zorumski, Charles F. Reiersen, Angela M. Nicol, Ginger E. Cirrito, John Lenze, Eric J. Tags: Review Source Type: research
Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition
in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled
Study
Conclusion In this exploratory trial, a single dose of Lu AG06466 showed
statistically significant positive effects on key measures of TS symptoms. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 30, 2021 Category: Psychiatry Authors: M üller-Vahl, Kirsten R. Fremer, Carolin Beals, Chan Ivkovic, Jelena Loft, Henrik Schindler, Christoph Tags: Original Paper Source Type: research
Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in
Depressive Disorders
Conclusion Adjunctive L-methylfolate may have modest efficacy in
antidepressant-treated adults with MDD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 18, 2021 Category: Psychiatry Authors: Maruf, Abdullah Al Poweleit, Ethan A. Brown, Lisa C. Strawn, Jeffrey R. Bousman, Chad A. Tags: Review Source Type: research
A Possible Type IV Hypersensitivity Reaction to Older Antiepileptic Drugs During and
After Recovery from COVID-19 Infection
Pharmacopsychiatry DOI: 10.1055/a-1678-7429Nearly two years after the onset of the coronavirus disease 2019 (COVID-19) pandemic,
healthcare workers face new and unexpected complications. Although accelerating the
vaccination process in recent months has reduced the incidence and mortality of the
COVID-19 infection, the general population (particularly vulnerable groups) remains
at risk of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants. Over the last two months, Iran has encountered the fifth wave of the
COVID-19 pandemic, i. e., the B....
Source: Pharmacopsychiatry - November 10, 2021 Category: Psychiatry Authors: Khosravi, Mohsen Tags: Letter to the Editor Source Type: research
