Frequencies of Genetic Polymorphisms of Clinically Relevant Gene-Drug Pairs in a German Psychiatric Inpatient Population
Discussion Our results suggest that our psychiatric inpatients were enriched with genotypes consistent with non-normal drug metabolism compared to reference populations. We therefore conclude that pharmacogenetic testing should be implemented in clinical practice to guide drug therapy. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 16, 2020 Category: Psychiatry Authors: Hahn, Martina M üller, Daniel J. Roll, Sibylle C. Tags: Original Paper Source Type: research
Treatment Goals for Patients with Schizophrenia — A Narrative Review of Physician and Patient Perspectives
Discussion Agreement between patients and physicians regarding valuation of treatment goals was high. However, physicians tended to put more emphasis on the classical “textbook” goals of symptom resolution and functioning, while patients stressed well-being and quality of life more. Results on treatment goals from patients are difficult to generalize, since recruiting representative patient samples is challenging and patient subgroups may have differing priorities. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (...
Source: Pharmacopsychiatry - December 8, 2020 Category: Psychiatry Authors: Gr ünder, Gerhard Bauknecht, Philipp Klingberg, Stefan Leopold, Karolina Paulzen, Michael Schell, Stefanie Stengler, Katarina Leucht, Stefan Tags: Review Source Type: research
Dose-Corrected Serum Concentrations and Metabolite to Parent Compound Ratios of Venlafaxine and Risperidone from Childhood to Old Age
Conclusions We suggest a higher clearance as a reason for lower CDsAM of VEN and RIS in children/adolescents compared to adults/elderlies. Metabolism of VEN or RIS by CYP2D6, characterized by MPRs, was not associated with age. However, MPRs of RIS were lower in children/adolescents, possibly due to a higher renal clearance of 9-OH-risperidone. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 8, 2020 Category: Psychiatry Authors: Fekete, Stefanie Scherf-Clavel, Maike Gerlach, Manfred Romanos, Marcel Kittel-Schneider, Sarah Unterecker, Stefan Egberts, Karin Tags: Original Paper Source Type: research
The History of Psychedelics in Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1310-3990Initial interest in the value of psychedelic drugs (“psychotomimetics”) in psychiatry began in the early 20th century, with explorations of the possibility that mescaline or peyote could produce psychosis-like effects. Over time, interest was focused on whether the effects of psychedelics could inform as to the underlying basis for psychiatric disorders. As research continued, and especially after the discovery of LSD in 1943, increasing interest in a role for psychedelics as adjuncts to psychotherapy began to evolve and became the major focus of work with psychedelics up to t...
Source: Pharmacopsychiatry - December 7, 2020 Category: Psychiatry Authors: Nichols, David E. Walter, Hannes Tags: Review Source Type: research
Psychedelics and Psychotherapy
Pharmacopsychiatry DOI: 10.1055/a-1312-7297Psychedelics have shown great promise in modern clinical trials for treating various psychiatric conditions. As a transdiagnostic treatment that exerts its effects through subjective experiences that leave enduring effects, it is akin to psychotherapy. To date, there has been insufficient discussion of how psychedelic therapy is similar to and different from conventional psychotherapy. In this article, we review the shared features of effective conventional psychotherapies and situate therapeutic psychedelic effects within those. We then discuss how psychedelic drug effects might ...
Source: Pharmacopsychiatry - December 7, 2020 Category: Psychiatry Authors: Nayak, Sandeep Johnson, Matthew W. Tags: Review Source Type: research
Neurotrophic Properties of Silexan, an Essential Oil from the Flowers
of Lavender-Preclinical Evidence for Antidepressant-Like
Properties
Conclusion Taken together, Silexan demonstrates antidepressant-like
effects in cellular as well as animal models for antidepressant activity.
Therefore, our data provides preclinical evidence for the clinical
antidepressant effects of Silexan in patients with mixed depression and
anxiety. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 30, 2020 Category: Psychiatry Authors: Friedland, Kristina Silani, Giacomo Schuwald, Anita Stockburger, Carola Koch, Egon N öldner, Michael M üller, Walter E. Tags: Original Paper Source Type: research
Novel Long-Acting Buprenorphine Medications for Opioid Dependence: Current Update
Pharmacopsychiatry DOI: 10.1055/a-1298-4508Opioid maintenance treatment with oral methadone or sublingual buprenorphine is the first-line treatment in opioid dependence. Three novel long-acting buprenorphine formulations have been approved or will be available soon: for subcutaneous weekly and monthly application, the depot formulations CAM 2038 (Buvidal®), the monthly depot formulation RBP-6000 (Sublocade™), and a 6-month buprenorphine implant (Probuphine™). Clinical data available so far on the efficacy of these 3 medications are given, and possible clinical implications are discussed. [...] Georg Thieme Verlag KG R...
Source: Pharmacopsychiatry - November 19, 2020 Category: Psychiatry Authors: Soyka, Michael Tags: Review Source Type: research
Association between Adherence with an Atypical Antipsychotic and with
Other Psychiatric Drugs in Patients with Bipolar Disorder
Conclusion Adherence with an atypical antipsychotic was not useful for
estimating adherence to other psychiatric drugs in about half of the
patients with bipolar disorder. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 17, 2020 Category: Psychiatry Authors: Bauer, Michael Glenn, Tasha Alda, Martin Grof, Paul Monteith, Scott Rasgon, Natalie Severus, Emanuel Whybrow, Peter C. Tags: Original Paper Source Type: research
Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis
In this study, we used Tph2
−/−
mice lacking brain serotonin to dissect the interplay between BDNF and the serotonin system in mediating the effects of antidepressant pharmacotherapy on adult neurogenesis in the hippocampus.
Methods Besides citalopram (CIT), we tested tianeptine (TIA), an antidepressant whose mechanism of action is not well understood. Specifically, we examined cell survival and endogenous concentrations of BDNF following daily injection of the drugs.
Results Twenty-one days of CIT, but not of TIA, led to a significant increase in the survival of newly generated cells in the dentate gyrus of wild-typ...
Source: Pharmacopsychiatry - November 16, 2020 Category: Psychiatry Authors: Petermann, Markus Kronenberg, Golo Mosienko, Valentina Bader, Michael Alenina, Natalia Hellweg, Rainer Klempin, Friederike Tags: Original Paper Source Type: research
Review and Consensus on Pharmacogenomic Testing in
Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1288-1061The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest,
in part due to divergent perceptions of the quality and completeness of the
evidence base and diverse perspectives on the clinical utility of PGx testing
among psychiatrists and other healthcare providers. Recognizing the current lack
of consensus within the field, the International Society of Psychiatric Genetics
assembled a group of experts to conduct a narrative synthesis of the PGx
literature, prescribing guidelines, and product labels r...
Source: Pharmacopsychiatry - November 4, 2020 Category: Psychiatry Authors: Bousman, Chad A. Bengesser, Susanne A. Aitchison, Katherine J. Amare, Azmeraw T. Aschauer, Harald Baune, Bernhard T. Asl, Bahareh Behroozi Bishop, Jeffrey R. Burmeister, Margit Chaumette, Boris Chen, Li-Shiun Cordner, Zachary A. Deckert, J ürgen Degenhar Tags: Review Source Type: research
Review and Consensus on Pharmacogenomic Testing in Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1288-1061The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part due to divergent perceptions of the quality and completeness of the evidence base and diverse perspectives on the clinical utility of PGx testing among psychiatrists and other healthcare providers. Recognizing the current lack of consensus within the field, the International Society of Psychiatric Genetics assembled a group of experts to conduct a narrative synthesis of the PGx literature, prescribing guidelines, and product labels related to psychotropic medications as well as the key consid...
Source: Pharmacopsychiatry - November 4, 2020 Category: Psychiatry Authors: Bousman, Chad A. Bengesser, Susanne A. Aitchison, Katherine J. Amare, Azmeraw T. Aschauer, Harald Baune, Bernhard T. Asl, Bahareh Behroozi Bishop, Jeffrey R. Burmeister, Margit Chaumette, Boris Chen, Li-Shiun Cordner, Zachary A. Deckert, J ürgen Degenhar Tags: Review Source Type: research
On a Very Basic Behavior in Science: Importance and Issues with
Quotations
Pharmacopsychiatry DOI: 10.1055/a-1246-3122This journal, founded in 1968, not only has a publication history of more than 5
decades but also stands for a distinct scientific focus in psychiatric pharmacology
or psychopharmacology: the research on medication treatments for mental disorders.
At some point, it is worth taking a broader look at what we are doing in psychiatry
or in medicine in general. That is why, in this issue, we are publishing a study by
Christopher Baethge 1 that typically may not
fit into the scope of Pharmacopsychiatry. As a psychiatrist and an...
Source: Pharmacopsychiatry - October 19, 2020 Category: Psychiatry Authors: Bauer, Michael Tags: Editorial Source Type: research
Subtypes of Clinical High Risk for Psychosis that Predict Antipsychotic Effectiveness in Long-Term Remission
Discussion These subtypes may be of clinical value in AP treatment decision-making in the CHR population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 12, 2020 Category: Psychiatry Authors: Zhang, TianHong Wang, JunJie Xu, LiHua Wei, YanYan Tang, XiaoChen Hu, YeGang Cui, HuiRu Tang, YingYing Hui, Li Li, ChunBo Wang, JiJun Tags: Original Paper Source Type: research
Safety Profile of Methylphenidate Under Long-Term Treatment in Adult
ADHD Patients – Results of the COMPAS Study
Conclusion In this so far longest-running clinical trial, methylphenidate
treatment was safe and well-tolerated. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 4, 2020 Category: Psychiatry Authors: Kis, Bernhard L ücke, Caroline Abdel-Hamid, Mona He ßmann, Philipp Graf, Erika Berger, Mathias Matthies, Swantje Borel, Patricia Sobanski, Esther Alm, Barbara R ösler, Michael Retz, Wolfgang Jacob, Christian Colla, Michael Huss, Michael Jans, Thomas va Tags: Original Paper Source Type: research
Lack of Smoking Effects on Pharmacokinetics of Oral
Paliperidone-analysis of a Naturalistic Therapeutic Drug Monitoring
Sample
Discussion Paliperidone is not affected by smoking, and paliperidone
dose-adjustments in smokers may not be necessary. This may be seen as an
essential difference to risperidone, whose cytochrome-mediated metabolism might
be affected by smoking. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 5, 2020 Category: Psychiatry Authors: Schoretsanitis, Georgios Haen, Ekkehard Conca, Andreas Piacentino, Daria Ridders, Florian Hiemke, Christoph Gr ünder, Gerhard Paulzen, Michael Tags: Original Paper Source Type: research
