Dose-Corrected Serum Concentrations and Metabolite to Parent Compound Ratios of Venlafaxine and Risperidone from Childhood to Old Age
Conclusions We suggest a higher clearance as a reason for lower CDsAM of VEN and RIS in children/adolescents compared to adults/elderlies. Metabolism of VEN or RIS by CYP2D6, characterized by MPRs, was not associated with age. However, MPRs of RIS were lower in children/adolescents, possibly due to a higher renal clearance of 9-OH-risperidone. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Pharmacopsychiatry - Category: Psychiatry Authors: Fekete, Stefanie Scherf-Clavel, Maike Gerlach, Manfred Romanos, Marcel Kittel-Schneider, Sarah Unterecker, Stefan Egberts, Karin Tags: Original Paper Source Type: research