Serious Adverse Drug Reactions to Antipsychotics in Minors with
Multiple Disabilities: Preventability and Potential Cost Savings by Therapeutic
Drug Monitoring
Discussion The routine implementation of TDM is urgently recommended for
antipsychotic treatment in CAMD to increase drug therapy safety. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 4, 2022 Category: Psychiatry Authors: Fekete, Stefanie G üntzel, Tim Egberts, Karin Geissler, Julia Neubert, Antje Gerlach, Manfred Romanos, Marcel Taurines, Regina Tags: Original Paper Source Type: research
Antipsychotic Monotherapy for Major Depressive Disorder: A Systematic
Review and Meta-Analysis
Pharmacopsychiatry DOI: 10.1055/a-1934-9856Although several randomized controlled trials (RCTs) have compared the
effectiveness, efficacy, and safety of antipsychotic monotherapy (APM) versus
placebo in patients with major depressive disorder (MDD), no meta-analysis has
examined this topic. We conducted a systematic literature search using MEDLINE
and Embase to identify relevant RCTs and performed a meta-analysis to compare
the following outcomes between APM and placebo: response and remission rates,
study discontinuation due to all causes, lack of efficacy, and a...
Source: Pharmacopsychiatry - October 18, 2022 Category: Psychiatry Authors: Nishi, Akira Sawada, Kyosuke Uchida, Hiroyuki Mimura, Masaru Takeuchi, Hiroyoshi Tags: Review Source Type: research
Metformin is Protective Against the Development of Mood
Disorders
Discussion These results provide proof-of-principle of combining gene
expression signature technology with pharmacoepidemiology to identify potential
novel drugs for treating mood disorders. Importantly, metformin may have utility
in the treatment of mood disorders, warranting future randomized controlled
trials to test its efficacy. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 28, 2022 Category: Psychiatry Authors: Lake, Jacqueline Bortolasci, Chiara C. Stuart, Amanda L. Pasco, Julie A. Kidnapillai, Srisaiyini Spolding, Briana Truong, Trang T. T. Panizzutti, Bruna Liu, Zoe S. J. Dean, Olivia M. Crowley, Tamsyn Richardson, Mark Kim, Jee Hyun Berk, Michael Williams, L Tags: Original Paper Source Type: research
Selective Serotonin Reuptake Inhibitors may Influence COVID-19
Prognosis through Antioxidant and Cytoprotective Pathways Mediated by Sigma 1
Receptor Agonism
Pharmacopsychiatry DOI: 10.1055/a-1909-2198 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 18, 2022 Category: Psychiatry Authors: Papadopoulos, Konstantinos I. Papadopoulou, Alexandra Aw, Tar-Choon Tags: Letter to the Editor Source Type: research
Linkage of Young Mania Rating Scale to Clinical Global Impression
Scale to Enhance Utility in Clinical Practice and Research
Trials
Discussion The current study findings offer clinicians meaningful cutoff
values to interpret YMRS scores. Moreover, these values contribute to the
definition of treatment targets, response, remission, and entry criteria in
mania trials. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 27, 2022 Category: Psychiatry Authors: Samara, Myrto T. Levine, Stephen Z. Leucht, Stefan Tags: Original Paper Source Type: research
Effects of Pharmacokinetic Gene Variation on Therapeutic Drug Levels
and Antidepressant Treatment Response
Discussion The present data support previous recommendations to reduce
starting doses of amitriptyline and to guide dose-adjustments via therapeutic
drug monitoring in CYP2D6 poor metabolizers. In addition, we propose including
CYP2C19 in routine testing in venlafaxine-treated patients to improve
therapy by raising awareness of the risk of low serum concentrations in CYP2C19
rapid/ultrarapid metabolizers. In summary, pk gene variation can predict
serum concentrations, and thus the combination of pharmacogenetic testing and
therapeutic drug monitoring i...
Source: Pharmacopsychiatry - July 15, 2022 Category: Psychiatry Authors: Scherf-Clavel, Maike Weber, Heike Wurst, Catherina Stonawski, Saskia Hommers, Leif Unterecker, Stefan Wolf, Christiane Domschke, Katharina Rost, Nicolas Br ückl, Tanja Lucae, Susanne Uhr, Manfred Binder, Elisabeth B. Menke, Andreas Deckert, J ürgen Tags: Original Paper Source Type: research
The Therapeutic Potential of Pimavanserin in the Treatment of
Hallucinogen Induced Psychosis and Persistent Perceptual
Symptoms
Pharmacopsychiatry DOI: 10.1055/a-1882-6802 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 11, 2022 Category: Psychiatry Authors: Colijn, Mark A. Tags: Letter to the Editor Source Type: research
Identification of Endocannabinoid Predictors of Treatment Outcomes in
Major Depressive Disorder: A Secondary Analysis of the First Canadian Biomarker
Integration Network in Depression (CAN-BIND 1) Study
Discussion Methylation of DAGLA is a promising candidate as a
marker of treatment outcomes for MDD and needs to be explored further. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 6, 2022 Category: Psychiatry Authors: Kim, Helena K. Zai, Gwyneth M üller, Daniel J. Husain, Muhammad I. Lam, Raymond W. Frey, Benicio N. Soares, Claudio N. Parikh, Sagar V. Milev, Roumen Foster, Jane A. Turecki, Gustavo Farzan, Faranak Mulsant, Benoit H. Kennedy, Sidney H. Tripathy, Shreejo Tags: Original Paper Source Type: research
Aripiprazole Once-Monthly Versus Oral Aripiprazole for Schizophrenia
in the Maintenance Phase: A Systematic Review and Network
Meta-Analysis
DiscussionAlthough both AOM and OARI were efficacious in the treatment of
schizophrenia during the maintenance phase, AOM was better accepted than
OARI. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 5, 2022 Category: Psychiatry Authors: Kishi, Taro Sakuma, Kenji Iwata, Nakao Tags: Original Paper Source Type: research
Pharmacological Treatment of Early-Onset Schizophrenia: A Critical
Review, Evidence-Based Clinical Guidance and Unmet Needs
Pharmacopsychiatry DOI: 10.1055/a-1854-0185Early-onset schizophrenia (EOS) – onset before age 18 – is linked
with great disease burden and disability. Decision-making for EOS
pharmacological treatment may be challenging due to conflicting information from
evidence and guidelines and unidentified care needs may remain unmet.We searched for systematic reviews, meta-analyses and umbrella reviews of EOS
pharmacological treatment published in PubMed over the past 10 years and
selected five clinical guidelines from Europe, North-America and Australia.
Based on prede...
Source: Pharmacopsychiatry - July 1, 2022 Category: Psychiatry Authors: Lopez-Morinigo, Javier-David Leucht, Stefan Arango, Celso Tags: Review Source Type: research
Influence of NOS1AP Risk Variants on the Corrected QT (QTc)
Interval in the Pharmacotherapy of Schizophrenia
Conclusions In this study, a significant interaction was found between
both NOS1AP variants, rs12143842 and rs10494366, and antipsychotic
treatment on the QTc interval in a sex-dependent manner. Our findings might be
relevant for adequate antipsychotic treatment in rs12143842 and rs10494366 major
allele carriers. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 22, 2022 Category: Psychiatry Authors: Esen-Sehir, Dilhan Kopf, Juliane H ägele, Sandra Plichta, Michael M. Reif, Andreas Freudenberg, Florian Tags: Original Paper Source Type: research
COVID-19 Prognosis in Association with Antidepressant
Use
Conclusion This study revealed an association between antidepressants and
COVID-19 prognosis. SSRIs were significantly associated with a lower risk of
severe outcomes, whereas TCAs were related to the poor prognosis of
COVID-19. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 2, 2022 Category: Psychiatry Authors: Min, Kyung Hyun Kim, Tae Hyeok Oh, Soo Jin Kim, Woorim Lee, Kyung Eun Tags: Original Paper Source Type: research
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Pharmacopsychiatry 2022; 03 Article in Thieme eJournals: Table of contents | Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 16, 2022 Category: Psychiatry Source Type: research
Clinical Outcomes after Clozapine Discontinuation in Patients with
Schizophrenia: A Systematic Review
Discussion Clinical outcomes generally worsen after clozapine
discontinuation. Clozapine rechallenge and olanzapine may be considered
following clozapine discontinuation. The outcomes after clozapine
discontinuation in clozapine non-responders remain inconclusive; therefore,
well-designed studies are warranted. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 5, 2022 Category: Psychiatry Authors: Miura, Gentaro Tanaka, Kouhei Kemuriyama, Takashi Misawa, Fuminari Uchida, Hiroyuki Mimura, Masaru Takeuchi, Hiroyoshi Tags: Review Source Type: research
Epigenetics for Drug Discovery: Dissecting the Effect of High
Antipsychotic Dosage and D2 Blockage on Peripheral DNA
Methylation
This study did not show any association between DNA methylation
and dosage variation for CPZe, PM%, and DDD. However, the probe
cg271403389 was consistently associated with antipsychotic dosage across the
three standardization methods. When looking at the genomic location of the most
significant probes, we found that 15% were intergenic, 23% were
in the distal promoter, 9% in the 3′untranslated region,
32% in the gene body, 3% in the 5′ untranslated region,
15% in the proximal promoter, and 3% in the first exon.
Discussion This study shows the i...
Source: Pharmacopsychiatry - April 28, 2022 Category: Psychiatry Authors: Adanty, Christopher Kim, Julia Strauss, John Qian, Jessica Remington, Gary Borlido, Carol Graff, Ariel Gerretsen, Philip De Luca, Vincenzo Tags: Original Paper Source Type: research
