Epigenetics for Drug Discovery: Dissecting the Effect of High Antipsychotic Dosage and D2 Blockage on Peripheral DNA Methylation

This study did not show any association between DNA methylation
and dosage variation for CPZe, PM%, and DDD. However, the probe
cg271403389 was consistently associated with antipsychotic dosage across the
three standardization methods. When looking at the genomic location of the most
significant probes, we found that 15% were intergenic, 23% were
in the distal promoter, 9% in the 3′untranslated region,
32% in the gene body, 3% in the 5′ untranslated region,
15% in the proximal promoter, and 3% in the first exon.
Discussion This study shows the importance of investigating the
relationship between DNA methylation and optimal antipsychotic dosage to
personalize treatment in SCZ. Future studies require larger prescription
databases to build on the results of this analysis. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Pharmacopsychiatry - April 28, 2022 Category: Psychiatry Authors: Adanty, Christopher Kim, Julia Strauss, John Qian, Jessica Remington, Gary Borlido, Carol Graff, Ariel Gerretsen, Philip De Luca, Vincenzo Tags: Original Paper Source Type: research