8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine

Discussion  The plasma concentration of 8-OH-MIR was as low as 1.42 nmol/L, whereas 8-OH-MIR-G had an approximate 59.50 times higher concentration than 8-OH-MIR, suggesting a significant role for hydroxylation of MIR and its glucuronidation in the Japanese population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Pharmacopsychiatry - June 2, 2019 Category: Psychiatry Authors: Shinozaki, Masataka Pierce, Jason Hayashi, Yuki Watanabe, Takashi Sasaki, Taro Komahashi-Sasaki, Hazuki Akiyama, Kazufumi Kato, Kazuko Inoue, Yoshimasa Tsuchimine, Shoko Yasui-Furukori, Norio Ozeki, Yuji Shimoda, Kazutaka Tags: Original Paper Source Type: research