Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats
A mounting number of studies have been documenting the carcinogenic potential of multiwalled carbon nanotubes (MWCNTs); however, only a few studies have evaluated the pulmonary carcinogenicity of MWCNTs in viv... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 19, 2022 Category: Toxicology Authors: Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, Satoshi Yokota, Norihiro Kobayashi, Makoto Ohnishi, Yuko Goto, Takamasa Numano, Hiroyuki Tsuda & hellip; Tags: Research Source Type: research
Chronic effects of two rutile TiO2 nanomaterials in human intestinal and hepatic cell lines
TiO2 nanomaterials (NMs) are present in a variety of food and personal hygiene products, and consumers are exposed daily to these NMs through oral exposition. While the bulk of ingested TiO2 NMs are eliminated ra... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 17, 2022 Category: Toxicology Authors: P égah Jalili, Benjamin-Christoph Krause, Rachelle Lanceleur, Agnès Burel, Harald Jungnickel, Alfonso Lampen, Peter Laux, Andreas Luch, Valérie Fessard and Kevin Hogeveen Tags: Research Source Type: research
Exposure to lead-free frangible firing emissions containing copper and ultrafine particulates leads to increased oxidative stress in firing range instructors
Since the introduction of copper based, lead-free frangible (LFF) ammunition to Air Force small arms firing ranges, instructors have reported symptoms including chest tightness, respiratory irritation, and met... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 15, 2022 Category: Toxicology Authors: Ryan J. McNeilly, Jennifer A. Schwanekamp, Logan S. Hyder, John P. Hatch, Brett T. Edwards, Jacob A. Kirsh, Jerimiah M. Jackson, Thomas Jaworek, Mark M. Methner and Christin M. Duran Tags: Research Source Type: research
Correction to: Dose –response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats
(Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 13, 2022 Category: Toxicology Authors: Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, George Daghlian, Young-Kwon Hong, Yasuhiro Yoshimatsu, Masanori Hirashim Tags: Correction Source Type: research
Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)
Copper oxide (CuO) nanoparticles (NPs) are known to trigger cytotoxicity in a variety of cell models, but the mechanism of cell death remains unknown. Here we addressed the mechanism of cytotoxicity in macroph... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 10, 2022 Category: Toxicology Authors: Govind Gupta, Francesca Cappellini, Lucian Farcal, Rosalba Gornati, Giovanni Bernardini and Bengt Fadeel Tags: Research Source Type: research
Aluminium oxide nanoparticles compromise spatial memory performance and proBDNF-mediated neuronal function in the hippocampus of rats
Alumina nanoparticles (aluminaNPs), which are widely used in a range of daily and medical fields, have been shown to penetrate blood-brain barrier, and distribute and accumulate in different brain areas. Altho... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 10, 2022 Category: Toxicology Authors: Wei Sun, Jia Li, Xiaoliang Li, Xiao Chen, Yazi Mei, Yang Yang and Lei An Tags: Research Source Type: research
The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment
The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these mater... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 7, 2022 Category: Toxicology Authors: Rachel Verdon, Vicki Stone, Fiona Murphy, Emily Christopher, Helinor Johnston, Shareen Doak, Ulla Vogel, Andrea Haase and Ali Kermanizadeh Tags: Short report Source Type: research
TFEB-lysosome pathway activation is associated with different cell death responses to carbon quantum dots in Kupffer cells and hepatocytes
Carbon dot has been widely used in biomedical field as a kind of nanomaterial with low toxicity and high biocompatibility. CDs has demonstrated its unique advantages in assisted drug delivery, target diagnosis... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 28, 2022 Category: Toxicology Authors: Yanting Pang, Ying Yao, Mengran Yang, Daming Wu, Ying Ma, Yuanjian Zhang and Ting Zhang Tags: Research Source Type: research
Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization
Epidemiological studies have suggested that elevated concentrations of particulate matter (PM) are strongly associated with the incidence of atherosclerosis, however, the underlying cellular and molecular mech... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 22, 2022 Category: Toxicology Authors: Sujin Ju, Leejin Lim, Young-Jae Ki, Dong-Hyun Choi and Heesang Song Tags: Research Source Type: research
Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study
Considering the expanding industrial applications of carbon nanotubes (CNTs), safety assessment of these materials is far less than needed. Very few long-term in vivo studies have been carried out. This is the... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 22, 2022 Category: Toxicology Authors: Dina Mourad Saleh, Shengyong Luo, Omnia Hosny Mohamed Ahmed, David B. Alexander, William T. Alexander, Sivagami Gunasekaran, Ahmed M. El-Gazzar, Mohamed Abdelgied, Takamasa Numano, Hiroshi Takase, Makoto Ohnishi, Susumu Tomono, Randa Hussein Abd el Hady, Tags: Research Source Type: research
Consequences of nano and microplastic exposure in rodent models: the known and unknown
The ubiquitous nature of micro- (MP) and nanoplastics (NP) is a growing environmental concern. However, their potential impact on human health remains unknown. Research increasingly focused on using rodent mod... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 21, 2022 Category: Toxicology Authors: Walison Augusto da Silva Brito, Fiona Mutter, Kristian Wende, Alessandra Lourenco Cecchini, Anke Schmidt and Sander Bekeschus Tags: Review Source Type: research
Dose –response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats
In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP) at a chemical plant suffered from lung diseases, including fibrosis, interstitial pneumonia, emphysema, and pneumothorax. ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 8, 2022 Category: Toxicology Authors: Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, George Daghlian, Young-Kwon Hong, Yasuhiro Yoshimatsu, Masanori Hirashim Tags: Research Source Type: research
Safety assessment of graphene oxide and microcystin-LR complex: a toxicological scenario beyond physical mixture
Nanomaterials have been widely used in electrochemistry, sensors, medicine among others applications, causing its inevitable environmental exposure. A raising question is the “carrier” effect due to unique sur... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 7, 2022 Category: Toxicology Authors: Ying Ma, Xiaomeng Ding, Qing Liu, Yanting Pang, Yuna Cao and Ting Zhang Tags: Research Source Type: research
Ultrasmall iron oxide nanoparticles cause significant toxicity by specifically inducing acute oxidative stress to multiple organs
Iron oxide nanoparticles have been approved by food and drug administration for clinical application as magnetic resonance imaging (MRI) and are considered to be a biocompatible material. Large iron oxide nano... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 29, 2022 Category: Toxicology Authors: Lin Wu, Wen Wen, Xiaofeng Wang, Danhua Huang, Jin Cao, Xueyong Qi and Song Shen Tags: Research Source Type: research
Combined exposure to fine particulate matter and high glucose aggravates endothelial damage by increasing inflammation and mitophagy: the involvement of vitamin D
Cardiovascular diseases (CVDs) are related to particulate matter (PM2.5) exposure. Researchers have not clearly determined whether hyperglycemia, a hallmark of diabetes, exacerbates PM2.5-induced endothelial dama... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 29, 2022 Category: Toxicology Authors: Tsai-Chun Lai, Yu-Chen Chen, Hui-Hua Cheng, Tzu-Lin Lee, Jaw-Shiun Tsai, I.-Ta Lee, Kuo-Ti Peng, Chiang-Wen Lee, Lee-Fen Hsu and Yuh-Lien Chen Tags: Research Source Type: research
