Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke
Wood combustion emissions have been studied previously either by in vitro or in vivo models using collected particles, yet most studies have neglected gaseous compounds. Furthermore, a more accurate and holist... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 15, 2020 Category: Toxicology Authors: Tuukka Ihantola, Sebastiano Di Bucchianico, Mikko Happo, Mika Ihalainen, Oskari Uski, Stefanie Bauer, Kari Kuuspalo, Olli Sippula, Jarkko Tissari, Sebastian Oeder, Anni Hartikainen, Teemu J. R önkkö, Maria-Viola Martikainen, Kati Huttunen, Petra Vartiai Tags: Research Source Type: research
Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice
Food-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets. Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 11, 2020 Category: Toxicology Authors: Christine Com éra, Christel Cartier, Eric Gaultier, Olivier Catrice, Quentin Panouille, Sarah El Hamdi, Kristof Tirez, Inge Nelissen, Vassilia Théodorou and Eric Houdeau Tags: Research Source Type: research
Oxygenated polycyclic aromatic hydrocarbons from ambient particulate matter induce electrophysiological instability in cardiomyocytes
Epidemiologic studies have suggested that elevated concentrations of particulate matter (PM) are strongly associated with an increased risk of developing cardiovascular diseases, including arrhythmia. However,... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 11, 2020 Category: Toxicology Authors: Sujin Ju, Leejin Lim, Han-Yi Jiao, Seok Choi, Jae Yeoul Jun, Young-Jae Ki, Dong-Hyun Choi, Ji yi Lee and Heesang Song Tags: Research Source Type: research
Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction
Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 8, 2020 Category: Toxicology Authors: Mingxiang Wang, Jin Li, Shunni Dong, Xiaobo Cai, Aili Simaiti, Xin Yang, Xinqiang Zhu, Jianhong Luo, Lin-Hua Jiang, Binyang Du, Peilin Yu and Wei Yang Tags: Research Source Type: research
The plastic brain: neurotoxicity of micro- and nanoplastics
Given the global abundance and environmental persistence, exposure of humans and (aquatic) animals to micro- and nanoplastics is unavoidable. Current evidence indicates that micro- and nanoplastics can be take... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 8, 2020 Category: Toxicology Authors: Minne Pr üst, Jonelle Meijer and Remco H. S. Westerink Tags: Review Source Type: research
Caloric restriction attenuates C57BL/6  J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure
Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanis... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 5, 2020 Category: Toxicology Authors: Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiaowen Zeng, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng & hellip; Tags: Research Source Type: research
Quantitative biokinetics over a 28  day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure
There is a steadily increasing quantity of silver nanoparticles (AgNP) produced for numerous industrial, medicinal and private purposes, leading to an increased risk of inhalation exposure for both professiona... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 5, 2020 Category: Toxicology Authors: Wolfgang G. Kreyling, Uwe Holzwarth, Stephanie Hirn, Carsten Schleh, Alexander Wenk, Martin Sch äffler, Nadine Haberl and Neil Gibson Tags: Research Source Type: research
Analysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity
Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 4, 2020 Category: Toxicology Authors: Erika Sato, Sandra A. McDonald, Yuwei Fan, Shaina Peterson, Joseph D. Brain and John J. Godleski Tags: Research Source Type: research
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells
The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative s... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 1, 2020 Category: Toxicology Authors: Sweelin Chew, Riikka Lampinen, Liudmila Saveleva, Paula Korhonen, Nikita Mikhailov, Alexandra Grubman, Jose M. Polo, Trevor Wilson, Mika Komppula, Teemu R önkkö, Cheng Gu, Alan Mackay-Sim, Tarja Malm, Anthony R. White, Pasi Jalava and Katja M. Kanninen Tags: Research Source Type: research
Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health
In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to t... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 1, 2020 Category: Toxicology Authors: Bruno Lamas, Natalia Martins Breyner and Eric Houdeau Tags: Review Source Type: research
Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions
Emissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations. Although the new passenger car regulat... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 27, 2020 Category: Toxicology Authors: Henri Hakkarainen, P äivi Aakko-Saksa, Maija Sainio, Tuukka Ihantola, Teemu J. Rönkkö, Päivi Koponen, Topi Rönkkö and Pasi I. Jalava Tags: Research Source Type: research
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale
Toxicity testing and regulation of advanced materials at the nanoscale, i.e. nanosafety, is challenged by the growing number of nanomaterials and their property variants requiring assessment for potential huma... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 25, 2020 Category: Toxicology Authors: Sabina Halappanavar, Sybille van den Brule, Penny Nymark, Laurent Gat é, Carole Seidel, Sarah Valentino, Vadim Zhernovkov, Pernille Høgh Danielsen, Andrea De Vizcaya, Henrik Wolff, Tobias Stöger, Andrey Boyadziev, Sarah Søs Poulsen, Jorid Birkelund Sà Tags: Review Source Type: research
Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes
Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been r... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 7, 2020 Category: Toxicology Authors: Omar Lozano, Christian Silva-Platas, H éctor Chapoy-Villanueva, Baruc E. Pérez, Jarmon G. Lees, Chrishan J. A. Ramachandra, Flavio F. Contreras-Torres, Anay Lázaro-Alfaro, EstefanÃa Luna-Figueroa, Judith Bernal-RamÃrez, Aldemar Gordillo-Galeano, Alfr Tags: Research Source Type: research
Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice
In this study, we aimed to evaluate the sex-dependent vulnera... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 22, 2020 Category: Toxicology Authors: Ran Li, Qing Sun, Sin Man Lam, Rucheng Chen, Junyao Zhu, Weijia Gu, Lu Zhang, He Tian, Kezhong Zhang, Lung-Chi Chen, Qinghua Sun, Guanghou Shui and Cuiqing Liu Tags: Research Source Type: research
Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model
Silica nanoparticles (SiNPs) are among the most widely manufactured and used nanoparticles. Concerns about potential health effects of SiNPs have therefore risen. Using a 3D tri-culture model of the alveolar l... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 21, 2020 Category: Toxicology Authors: Tonje Skuland, Marit L åg, Arno C. Gutleb, Bendik C. Brinchmann, Tommaso Serchi, Johan Øvrevik, Jørn A. Holme and Magne Refsnes Tags: Research Source Type: research
