Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation
Recently, Borm and Driscoll published a commentary discussing grouping of Poorly Soluble particles of Low Toxicity (PSLTs) and the use of rats as an animal model for human hazard assessment of PSLTs (Particle ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 21, 2019 Category: Toxicology Authors: Anne T. Saber, Sarah S. Poulsen, Niels Hadrup, Nicklas R. Jacobsen and Ulla Vogel Tags: Commentary Source Type: research
Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
With ever-increasing exposure to engineered nanomaterials (NMs), there is an urgent need to evaluate the probability of consequential adverse effects. The potential for NM translocation to distal organs is a r... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 19, 2019 Category: Toxicology Authors: Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz and Vicki Stone Tags: Research Source Type: research
Correction to: Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity
It was highlighted that the original article [1] contained the wrong Fig. 1. (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 18, 2019 Category: Toxicology Authors: Ching-Yi Chen, Po-Lin Liao, Chi-Hao Tsai, Yen-Ju Chan, Yu-Wen Cheng, Ling-Ling Hwang, Kuan-Hung Lin, Ting-Ling Yen and Ching-Hao Li Tags: Correction Source Type: research
Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species
Silicon dioxide nanoparticles (SiO2 NPs) are one of the most widely utilized NPs in various food sectors. However, the potential endocrine toxicity of SiO2 NPs has not been characterized. (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 7, 2019 Category: Toxicology Authors: Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou and Ning Gu Tags: Research Source Type: research
Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity
Amorphous silica nanoparticles (SiO2 NPs) have been regarded as relatively benign nanomaterials, however, this widely held opinion has been questioned in recent years by several reports on in vitro and in vivo... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 29, 2019 Category: Toxicology Authors: Laura Rubio, Georgios Pyrgiotakis, Juan Beltran-Huarac, Yipei Zhang, Joshi Gaurav, Glen Deloid, Anastasia Spyrogianni, Kristopher A. Sarosiek, Dhimiter Bello and Philip Demokritou Tags: Research Source Type: research
Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice
Engineered nanoparticles (NPs) have been shown to enhance allergic airways disease in mice. However, the influence of the different physicochemical properties of these particles on their adjuvant properties is... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 28, 2019 Category: Toxicology Authors: Susan Dekkers, James G. Wagner, Rob J. Vandebriel, Elyse A. Eldridge, Selina V. Y. Tang, Mark R. Miller, Isabella R ömer, Wim H. de Jong, Jack R. Harkema and Flemming R. Cassee Tags: Research Source Type: research
An in-depth multi-omics analysis in RLE-6TN rat alveolar epithelial cells allows for nanomaterial categorization
Nanomaterials (NMs) can be fine-tuned in their properties resulting in a high number of variants, each requiring a thorough safety assessment. Grouping and categorization approaches that would reduce the amoun... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 25, 2019 Category: Toxicology Authors: Isabel Karkossa, Anne Bannuscher, Bryan Hellack, Aileen Bahl, Sophia Buhs, Peter Nollau, Andreas Luch, Kristin Schubert, Martin von Bergen and Andrea Haase Tags: Research Source Type: research
Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity
Gold nanoparticles (Au-NPs) have extensive applications in electronics and biomedicine, resulting in increased exposure and prompting safety concerns for human health. After absorption, nanoparticles enter cir... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 16, 2019 Category: Toxicology Authors: Ching-Yi Chen, Po-Lin Liao, Chi-Hao Tsai, Yen-Ju Chan, Yu-Wen Cheng, Ling-Ling Hwang, Kuan-Hung Lin, Ting-Ling Yen and Ching-Hao Li Tags: Research Source Type: research
Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells
The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace m... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 7, 2019 Category: Toxicology Authors: Katelyn J. Siegrist, Steven H. Reynolds, Dale W. Porter, Robert R. Mercer, Alison K. Bauer, David Lowry, Lorenzo Cena, Todd A. Stueckle, Michael L. Kashon, John Wiley, Jeffrey L. Salisbury, John Mastovich, Kristin Bunker, Mark Sparrow, Jason S. Lupoi, Ale Tags: Research Source Type: research
HIF-1 α is a key mediator of the lung inflammatory potential of lithium-ion battery particles
Li-ion batteries (LIB) are increasingly used worldwide. They are made of low solubility micrometric particles, implying a potential for inhalation toxicity in occupational settings and possibly for consumers. ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 18, 2019 Category: Toxicology Authors: Violaine Sironval, Mihaly Palmai-Pallag, Rita Vanbever, Fran çois Huaux, Jorge Mejia, Stéphane Lucas, Dominique Lison and Sybille van den Brule Tags: Research Source Type: research
Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration
Potassium octatitanate fibers (K2O •8TiO2, POT fibers) are used as an asbestos substitute. Their physical characteristics suggest that respirable POT fibers are likely to be carcinogenic in the lung and pleura. Ho... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 2, 2019 Category: Toxicology Authors: Mohamed Abdelgied, Ahmed M. El-Gazzar, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Khaled Abbas Abdou, Satoru Takahashi, David B. Alexander and Hiroyuki Tags: Research Source Type: research
Distribution of nickel and chromium containing particles from tattoo needle wear in humans and its possible impact on allergic reactions
Allergic reactions to tattoos are amongst the most common side effects occurring with this permanent deposition of pigments into the dermal skin layer. The characterization of such pigments and their distribut... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 27, 2019 Category: Toxicology Authors: Ines Schreiver, Bernhard Hesse, Christian Seim, Hiram Castillo-Michel, Lars Anklamm, Julie Villanova, Nadine Dreiack, Adrien Lagrange, Randolph Penning, Christa De Cuyper, Remi Tucoulou, Wolfgang B äumler, Marine Cotte and Andreas Luch Tags: Research Source Type: research
The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 16, 2019 Category: Toxicology Authors: Cristina Pavan, Massimo Delle Piane, Maria Gullo, Francesca Filippi, Bice Fubini, Peter Hoet, Claire J. Horwell, Fran çois Huaux, Dominique Lison, Cristina Lo Giudice, Gianmario Martra, Eliseo Montfort, Roel Schins, Marialore Sulpizi, Karsten Wegner, Mic Tags: Commentary Source Type: research
Titanium dioxide nanoparticles oral exposure to pregnant rats and its distribution
Titanium dioxide (TiO2) nanoparticles are among the most manufactured nanomaterials in the industry, and are used in food products, toothpastes, cosmetics and paints. Pregnant women as well as their conceptuses m... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 18, 2019 Category: Toxicology Authors: Jinsoo Lee, Ji-Seong Jeong, Sang Yun Kim, Min-Kyu Park, Sung-Deuk Choi, Un-Jung Kim, Kwangsik Park, Eun Ju Jeong, Sang-Yoon Nam and Wook-Joon Yu Tags: Research Source Type: research
Iron oxide nanoparticles induce reversible endothelial-to-mesenchymal transition in vascular endothelial cells at acutely non-cytotoxic concentrations
Iron oxide nanoparticles (IONPs) have been extensively studied in different biomedical fields. Recently, the non-cytotoxic concentration of IONPs induced cell-specific response raised concern of their safety. ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 12, 2019 Category: Toxicology Authors: Tao Wen, Lifan Du, Bo Chen, Doudou Yan, Aiyun Yang, Jian Liu, Ning Gu, Jie Meng and Haiyan Xu Tags: Research Source Type: research
