Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty
The toxicity of released metallic particles generated in metal-on-metal (MoM) total hip arthroplasty (THA) using cobalt chromium (CoCr) has raised concerns regarding their safety amongst both surgeons and the ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 27, 2020 Category: Toxicology Authors: Jing Xu, Junyao Yang, Jian Chen, Xiaoli Zhang, Yuanhao Wu, Alister Hart, Agata Nyga and Julia C. Shelton Tags: Research Source Type: research
Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF- κB-dependent pathway in lung epithelial cells
Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress i... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 14, 2020 Category: Toxicology Authors: Yu-Chen Chen, Tzu-Yi Chuang, Chen-Wei Liu, Chi-Wei Liu, Tzu-Lin Lee, Tsai-Chun Lai and Yuh-Lien Chen Tags: Research Source Type: research
Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro
Engineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological effects of end-of-lifecycle recycling and disposal of virgin and nano-... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 12, 2020 Category: Toxicology Authors: Jayme P. Coyle, Raymond C. Derk, Tiffany G. Kornberg, Dilpreet Singh, Jake Jensen, Sherri Friend, Robert Mercer, Todd A. Stueckle, Philip Demokritou, Yon Rojanasakul and Liying W. Rojanasakul Tags: Research Source Type: research
Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells
Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and i... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 10, 2020 Category: Toxicology Authors: Rongrong Wu, Johan H ögberg, Mikael Adner, Patricia Ramos-Ramírez, Ulla Stenius and Huiyuan Zheng Tags: Research Source Type: research
Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties
Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to at... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 8, 2020 Category: Toxicology Authors: Katja Maria Bendtsen, Louise Gren, Vilhelm Berg Malmborg, Pravesh Chandra Shukla, Martin Tun ér, Yona J. Essig, Annette M. Krais, Per Axel Clausen, Trine Berthing, Katrin Loeschner, Nicklas Raun Jacobsen, Henrik Wolff, Joakim Pagels and Ulla Birgitte Vog Tags: Research Source Type: research
PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis
Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is known to significantly con... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 4, 2020 Category: Toxicology Authors: Yu-Wen Chen, Mei-Zi Huang, Chyi-Liang Chen, Chieh-Ying Kuo, Chia-Yu Yang, Chuan Chiang-Ni, Yi-Ywan M. Chen, Chia-Ming Hsieh, Hui-Yu Wu, Ming-Ling Kuo, Cheng-Hsun Chiu and Chih-Ho Lai Tags: Research Source Type: research
Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?
Exposure to air pollution has been associated with adverse effects on human health, and ultimately increased morbidity and mortality. This is predominantly due to hazardous effects on the cardiovascular system... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 4, 2020 Category: Toxicology Authors: Siri A. N. Holme, Torben Sigsgaard, J ørn A. Holme and Gitte Juel Holst Tags: Review Source Type: research
Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies
Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have b... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 25, 2020 Category: Toxicology Authors: Irini M. Dijkhoff, Barbara Drasler, Bedia Begum Karakocak, Alke Petri-Fink, Giuseppe Valacchi, Marc Eeman and Barbara Rothen-Rutishauser Tags: Review Source Type: research
Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats
Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety r... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 17, 2020 Category: Toxicology Authors: Min Beom Heo, Minjeong Kwak, Kyu Sup An, Hye Jin Kim, Hyeon Yeol Ryu, So Min Lee, Kyung Seuk Song, In Young Kim, Ji-Hwan Kwon and Tae Geol Lee Tags: Research Source Type: research
A response to the letter to the editor by Driscoll et al.
In response to the Letter to the Editor by Kevin Driscoll et al., we certainly agree that particle clearance halftimes are increased with increasing lung burden in rats, hamsters and mice, whereas complete inh... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 16, 2020 Category: Toxicology Authors: Anne T. Saber, Sarah S. Poulsen, Niels Hadrup, Nicklas R. Jacobsen and Ulla Vogel Tags: Letter to the Editor Source Type: research
Comment on Saber et al. (2019), “Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation”
In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make seve... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 16, 2020 Category: Toxicology Authors: Kevin E. Driscoll, Paul A. Borm, Ishrat Chaudhuri, Len Levy, Mei Yong, David Warheit, Robert McCunney and G ünter Oberdörster Tags: Letter to the Editor Source Type: research
Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia
Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues and tiny vascular structures. However, the bios... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 11, 2020 Category: Toxicology Authors: Tianshu Wu, Xue Liang, Xi Liu, Yimeng Li, Yutong Wang, Lu Kong and Meng Tang Tags: Research Source Type: research
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials
Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life. Understa... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 11, 2020 Category: Toxicology Authors: Battuja Batbajar Dugershaw, Leonie Aengenheister, Signe Schmidt Kj ølner Hansen, Karin Sørig Hougaard and Tina Buerki-Thurnherr Tags: Review Source Type: research
Toxicity of particles emitted by fireworks
This study was designed to test the hypotheses that pyrotechnic firework displays introduce significant a... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 2, 2020 Category: Toxicology Authors: Christina Hickey, Christopher Gordon, Karen Galdanes, Martin Blaustein, Lori Horton, Steven Chillrud, James Ross, Lital Yinon, Lung Chi Chen and Terry Gordon Tags: Research Source Type: research
Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation
Commercial uranium mining on the Navajo Nation has subjected communities on tribal lands in the Southwestern United States to exposures from residual environmental contamination. Vascular health effects from t... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 1, 2020 Category: Toxicology Authors: Bethany Sanchez, Xixi Zhou, Amy S. Gardiner, Guy Herbert, Selita Lucas, Masako Morishita, James G. Wagner, Ryan Lewandowski, Jack R. Harkema, Chris Shuey, Matthew J. Campen and Katherine E. Zychowski Tags: Research Source Type: research
