Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion
Exposure to particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is a risk factor for developing pulmonary diseases and the worsening of ongoing disease. Mitochondrial fission and fusion ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 18, 2023 Category: Toxicology Authors: Qi Liu, Jiali Weng, Chenfei Li, Yi Feng, Meiqin Xie, Xiaohui Wang, Qing Chang, Mengnan Li, Kian Fan Chung, Ian M Adcock, Yan Huang, Hai Zhang and Feng Li Tags: Research Source Type: research
A 90-day oral exposure to food-grade gold at relevant human doses impacts the gut microbiota and the local immune system in a sex-dependent manner in mice
Edible gold (Au) is commonly used as a food additive (E175 in EU) for confectionery and cake decorations, coatings and in beverages. Food-grade gold is most often composed of thin Au sheets or flakes exhibitin... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 13, 2023 Category: Toxicology Authors: Lauris Evariste, Bruno Lamas, Sandrine Ellero-Simatos, Laure Khoury, Christel Cartier, Eric Gaultier, Benoit Chassaing, Nicolas Feltin, Laurent Devoille, Georges Favre, Marc Audebert and Eric Houdeau Tags: Research Source Type: research
Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asthmatic subjects
We examined wh... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 10, 2023 Category: Toxicology Authors: Karin Rosenkilde Laursen, Nichlas Vous Christensen, Frans AA Mulder, J örg Schullehner, Hans Jürgen Hoffmann, Annie Jensen, Peter Møller, Steffen Loft, Anna-Carin Olin, Berit B. Rasmussen, Bernadette Rosati, Bo Strandberg, Marianne Glasius, Merete Bild Tags: Research Source Type: research
Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice
We previously found that air pollution particles reaching the gastrointestinal tract elicit gut inflammation as shown by up-regulated gene expression of pro-inflammatory cytokines and monocyte/macrophage marke... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 3, 2023 Category: Toxicology Authors: Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Zora Baumann, Neena Parayil, Faiza Noreen, Julien Roux, Daniel T. Meier and Claudia Cavelti-Weder Tags: Research Source Type: research
Oral intake of titanium dioxide nanoparticles affect the course and prognosis of ulcerative colitis in mice: involvement of the ROS-TXNIP-NLRP3 inflammasome pathway
Titanium dioxide (TiO2), no matter in nanoscale or micron sizes, has been widely used in food industry as additives for decades. Given the potential impact of TiO2 on the gastrointestinal epithelial and parenchym... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 22, 2023 Category: Toxicology Authors: Shumin Duan, Hongbo Wang, Yanjun Gao, Xiang Wang, Lizhi Lyu and Yun Wang Tags: Research Source Type: research
Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats
Though titanium dioxide (TiO2) is generally considered to have a low impact in the human body, the safety of TiO2 containing nanosized particles (NPs) has attracted attention. We found that the toxicity of silver... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - June 20, 2023 Category: Toxicology Authors: Jun-ichi Akagi, Yasuko Mizuta, Hirotoshi Akane, Takeshi Toyoda and Kumiko Ogawa Tags: Research Source Type: research
A Nano-QSTR model to predict nano-cytotoxicity: an approach using human lung cells data
The widespread use of new engineered nanomaterials (ENMs) in industries such as cosmetics, electronics, and diagnostic nanodevices, has been revolutionizing our society. However, emerging studies suggest that ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 22, 2023 Category: Toxicology Authors: Jo ão Meneses, Michael González-Durruthy, Eli Fernandez-de-Gortari, Alla P. Toropova, Andrey A. Toropov and Ernesto Alfaro-Moreno Tags: Research Source Type: research
MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts
Copper oxide nanoparticles (Nano-CuO) are one of the most produced and used nanomaterials. Previous studies have shown that exposure to Nano-CuO caused acute lung injury, inflammation, and fibrosis. However, t... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 22, 2023 Category: Toxicology Authors: Yuanbao Zhang, Yiqun Mo, Yue Zhang, Jiali Yuan and Qunwei Zhang Tags: Research Source Type: research
Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust
Airborne pollution particles have been shown to translocate from the mother ’s lung to the fetal circulation, but their distribution and internal placental-fetal tissue load remain poorly explored. Here, we inv... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 18, 2023 Category: Toxicology Authors: Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bov é, Maarten BJ Roeffaers, Pascale Chavatte-Palmer, Anne Couturier-Tarrade and Flemming R Cassee Tags: Research Source Type: research
An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma
Asbestos is a fibrous mineral that was widely used in the past. However, asbestos inhalation is associated with an aggressive type of cancer known as malignant mesothelioma (MM). After inhalation, an iron-rich... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 8, 2023 Category: Toxicology Authors: Maya-Liliana Avramescu, Christian Potiszil, Tak Kunihiro, Kazunori Okabe and Eizo Nakamura Tags: Research Source Type: research
Uncovering the Fate and Risks of Intravenously Injected Prussian Blue Nanoparticles in mice by an Integrated Methodology of Toxicology, Pharmacokinetics, Proteomics, and Metabolomics
Prussian blue (PB) nanoparticles (NPs) have been intensively investigated for medical applications, but an in-depth toxicological investigation of PB NPs has not been implemented. In the present study, a compr... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - May 5, 2023 Category: Toxicology Authors: Haijing Qu, Xing Jin, Wei Cheng, Dongqi Wu, Boyu Ma, Chenmei Lou, Jian Zheng, Lijia Jing, Xiangdong Xue and Yang Wang Tags: Research Source Type: research
Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract
Inhalation is a portal-of-entry for aerosols via the respiratory tract where particulate burden accumulates depending on sites of particle deposition, normal clearance mechanisms, and particle solubility. The ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 27, 2023 Category: Toxicology Authors: James S. Brown and Gary L. Diamond Tags: Research Source Type: research
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats
Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in the air has made inhalation exposure to MNPs a majo... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 23, 2023 Category: Toxicology Authors: Chelsea M Cary, Talia N Seymore, Dilpreet Singh, Kinal N Vayas, Michael J Goedken, Samantha Adams, Marianne Polunas, Vasanthi R Sunil, Debra L Laskin, Philip Demokritou and Phoebe A Stapleton Tags: Research Source Type: research
Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone
Microbial dysbiosis is a potential mediator of air pollution-induced adverse outcomes. However, a systemic comparison of the lung and gut microbiome alterations and lung-gut axis following air pollution exposu... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 21, 2023 Category: Toxicology Authors: Md Habibul Hasan Mazumder, Jasleen Gandhi, Nairrita Majumder, Lei Wang, Robert Ian Cumming, Sydney Stradtman, Murugesan Velayutham, Quincy A. Hathaway, Jonathan Shannahan, Gangqing Hu, Timothy R. Nurkiewicz, Robert M. Tighe, Eric E. Kelley and Salik Hussa Tags: Research Source Type: research
Prenatal PM2.5 exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis
As one of the environmental risk factors for human health, atmospheric fine particulate matter (PM2.5) contributes to cognitive deterioration in addition to respiratory and cardiovascular injuries. Recently, incr... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 20, 2023 Category: Toxicology Authors: Yanwen Hou, Wei Yan, Lin Guo, Guangke Li and Nan Sang Tags: Research Source Type: research
