Differential pulmonary toxicity and autoantibody formation in genetically distinct mouse strains following combined exposure to silica and diesel exhaust particles
Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimm... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 27, 2024 Category: Toxicology Authors: Lisa MF Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen AJ Vanoirbeek, Kenneth Michael Pollard, Manosij Ghosh and Peter HM Hoet Tags: Research Source Type: research
Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry
Airborne environmental and engineered nanoparticles (NPs) are inhaled and deposited in the respiratory system. The inhaled dose of such NPs and their deposition location in the lung determines their impact on ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 17, 2024 Category: Toxicology Authors: Denisa Lizonova, Amogh Nagarkar, Philip Demokritou and Georgios A. Kelesidis Tags: Research Source Type: research
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive fun... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 15, 2024 Category: Toxicology Authors: Henna J äntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm and Paula Korhonen Tags: Research Source Type: research
Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum
Currently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on the animal and human organism remains not fully understood. The digestiv... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 6, 2024 Category: Toxicology Authors: Ismena Ga łęcka, Natalia Szyryńska and Jarosław Całka Tags: Research Source Type: research
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
Micro- and nanoplastics (MNPs) represent one of the most widespread environmental pollutants of the twenty-first century to which all humans are orally exposed. Upon ingestion, MNPs pass harsh biochemical cond... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 4, 2024 Category: Toxicology Authors: Hugo Brouwer, Mojtaba Porbahaie, Sjef Boeren, Mathias Busch and Hans Bouwmeester Tags: Research Source Type: research
Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
In this study, we traced the biodistribution of ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 31, 2024 Category: Toxicology Authors: Joycie Shanmugiah, Javeria Zaheer, Changkeun Im, Choong Mo Kang and Jin Su Kim Tags: Research Source Type: research
Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles
Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. However, studies in rodents have shown that certain mul... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 31, 2024 Category: Toxicology Authors: Stella Marie Reamon-Buettner, Susanne Rittinghausen, Annika Klauke, Andreas Hiemisch and Christina Ziemann Tags: Research Source Type: research
ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials
As the demand and application of engineered nanomaterials have increased, their potential toxicity to the central nervous system has drawn increasing attention. Tunneling nanotubes (TNTs) are novel cell –cell c... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 15, 2024 Category: Toxicology Authors: Xinpei Lin, Wei Wang, Xiangyu Chang, Cheng Chen, Zhenkun Guo, Guangxia Yu, Wenya Shao, Siying Wu, Qunwei Zhang, Fuli Zheng and Huangyuan Li Tags: Research Source Type: research
Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism
Nanoplastics (NPs) are omnipresent in our lives as a new type of pollution with a tiny size. It can enter organisms from the environment, accumulate in the body, and be passed down the food chain. Inflammatory... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 18, 2023 Category: Toxicology Authors: Juan Ma, Yin Wan, Lingmin Song, Luchen Wang, Huimei Wang, Yingzhi Li and Danfei Huang Tags: Research Source Type: research
Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood –retinal barrier damages and disease susceptibilities
The association between air pollution and retinal diseases such as age-related macular degeneration (AMD) has been demonstrated, but the pathogenic correlation is unknown. Damage to the outer blood –retinal bar... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 18, 2023 Category: Toxicology Authors: Yuzhou Gu, Feiyin Sheng, Mengqin Gao, Li Zhang, Shengjie Hao, Shuying Chen, Rongrong Chen, Yili Xu, Di Wu, Yu Han, Lu Chen, Ye Liu, Bing Lu, Wei Zhao, Xiaoming Lou, Zhijian Chen & hellip; Tags: Research Source Type: research
Maternal exposure to nano-titanium dioxide impedes fetal development via endothelial-to-mesenchymal transition in the placental labyrinth in mice
Extensive production and usage of commercially available products containing TiO2 NPs have led to accumulation in the human body. The deposition of TiO2 NPs has even been detected in the human placenta, which rai... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 11, 2023 Category: Toxicology Authors: Xianjie Li, Yinger Luo, Di Ji, Zhuyi Zhang, Shili Luo, Ya Ma, Wulan Cao, Chunwei Cao, Phei Er Saw, Hui Chen and Yanhong Wei Tags: Research Source Type: research
Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response
Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF- κB and c-Jun, activation of mitogen activated protein k... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 8, 2023 Category: Toxicology Authors: M. Friberg, A. F. Behndig, J. A. Bosson, Ala Muala, S. Barath, R. Dove, D. Glencross, F. J. Kelly, A. Blomberg, I. S. Mudway, T. Sandstr öm and J. Pourazar Tags: Research Source Type: research
Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics
Nanoplastics (NPs) could be released into environment through the degradation of plastic products, and their content in the air cannot be ignored. To date, no studies have focused on the cardiac injury effects... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 29, 2023 Category: Toxicology Authors: Tianyi Zhang, Sheng Yang, Yiling Ge, Xin Wan, Yuxin Zhu, Fei Yang, Jie Li, Saisai Gong, Yanping Cheng, Chengyu Hu, Zaozao Chen, Lihong Yin, Yuepu Pu and Geyu Liang Tags: Research Source Type: research
Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life
Perinatal exposure to titanium dioxide (TiO2), as a foodborne particle, may influence the intestinal barrier function and the susceptibility to develop inflammatory bowel disease (IBD) later in life. Here, we inv... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 23, 2023 Category: Toxicology Authors: Caroline Carl é, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanu Tags: Research Source Type: research
Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo
Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, and have raised concerns regarding their potential risks to human health, particularly neurotoxicity. Th... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 22, 2023 Category: Toxicology Authors: Yuji Huang, Boxuan Liang, Zhiming Li, Yizhou Zhong, Bo Wang, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Weicui Min, Xiliang Yan, Yanhong Deng, Yu Feng, Ruobing Bai, Bingchi Fan, Xingfen Yang & hellip; Tags: Research Source Type: research
