Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation
The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms w... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 23, 2020 Category: Toxicology Authors: De-Ping Wang, Zhao-Jun Wang, Rong Zhao, Cai-Xia Lin, Qian-Yu Sun, Cai-Ping Yan, Xin Zhou and Ji-Min Cao Tags: Research Source Type: research
Combination of the BeWo b30 placental transport model and the embryonic stem cell test to assess the potential developmental toxicity of silver nanoparticles
Silver nanoparticles (AgNPs) are used extensively in various consumer products because of their antimicrobial potential. This requires insight in their potential hazards and risks including adverse effects dur... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 10, 2020 Category: Toxicology Authors: Ashraf Abdelkhaliq, Meike van der Zande, Ruud J. B. Peters and Hans Bouwmeester Tags: Research Source Type: research
Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo
The terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 26, 2020 Category: Toxicology Authors: Sivakumar Murugadoss, Frederic Brassinne, Noham Sebaihi, Jasmine Petry, Stevan M. Cokic, Kirsten L. Van Landuyt, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet and Sybille van den Brule Tags: Research Source Type: research
Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats
Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emi... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 29, 2020 Category: Toxicology Authors: Alex P. Carll, Renata Salatini, Sandra V. Pirela, Yun Wang, Zhengzhi Xie, Pawel Lorkiewicz, Nazratan Naeem, Yong Qian, Vincent Castranova, John J. Godleski and Philip Demokritou Tags: Research Source Type: research
Effects of PM2.5 and gases exposure during prenatal and early-life on autism –like phenotypes in male rat offspring
Epidemiological studies have reported associations between elevated air pollution and autism spectrum disorders (ASD). However, we hypothesized that exposure to air pollution that mimics real world scenarios, ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 29, 2020 Category: Toxicology Authors: Baharan Emam, Abbas Shahsavani, Fariba Khodagholi, Saeed Motesaddi Zarandi, Philip K. Hopke, Mostafa Hadei, Hamidreza Behbahani and Maryam Yarahmadi Tags: Research Source Type: research
LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals
Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO2 (LCO) is one of the most used for the cathode of LIB. LCO particles induce oxidative stress in mouse lungs d... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 29, 2020 Category: Toxicology Authors: Violaine Sironval, Vittoria Scagliarini, Sivakumar Murugadoss, Maura Tomatis, Yousof Yakoub, Francesco Turci, Peter Hoet, Dominique Lison and Sybille van den Brule Tags: Research Source Type: research
Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats
Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 28, 2020 Category: Toxicology Authors: Hye-Yeon Choi, Yong-Hoon Lee, Cheol-Hong Lim, Yong-Soon Kim, In-Seop Lee, Ji-Min Jo, Ha-Young Lee, Hyo-Geun Cha, Hee Jong Woo and Dong-Seok Seo Tags: Research Source Type: research
Identifying the reactive sites of hydrogen peroxide decomposition and hydroxyl radical formation on chrysotile asbestos surfaces
Fibrous chrysotile has been the most commonly applied asbestos mineral in a range of technical applications. However, it is toxic and carcinogenic upon inhalation. The chemical reactivity of chrysotile fiber s... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 20, 2020 Category: Toxicology Authors: Martin Walter, Walter D. C. Schenkeveld, Gerald Geroldinger, Lars Gille, Michael Reissner and Stephan M. Kraemer Tags: Research Source Type: research
Mechanisms of lung toxicity induced by biomass burning aerosols
Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial f... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 20, 2020 Category: Toxicology Authors: Michal Pardo, Chunlin Li, Quanfu He, Smadar Levin-Zaidman, Michael Tsoory, Qingqing Yu, Xinming Wang and Yinon Rudich Tags: Research Source Type: research
Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats
Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Al... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 10, 2020 Category: Toxicology Authors: Astrid Skovmand, Aaron Erdely, James M. Antonini, Timothy R. Nurkiewicz, Mohammad Shoeb, Tracy Eye, Vamsi Kodali, Katrin Loeschner, Janja Vidmar, J ørgen S. Agerholm, Sandra Goericke-Pesch, Ulla Vogel and Karin S. Hougaard Tags: Research Source Type: research
Is aggregated synthetic amorphous silica toxicologically relevant?
The regulatory definition(s) of nanomaterials (NMs) frequently uses the term ‘agglomerates and aggregates’ (AA) despite the paucity of evidence that AA are significantly relevant from a nanotoxicological persp... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 3, 2020 Category: Toxicology Authors: Sivakumar Murugadoss, Sybille van den Brule, Frederic Brassinne, Noham Sebaihi, Jorge Mejia, St éphane Lucas, Jasmine Petry, Lode Godderis, Jan Mast, Dominique Lison and Peter H. Hoet Tags: Research Source Type: research
Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles
Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO2 NPs) have been increasingly exposed to the environment and the public. However, the he... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 27, 2019 Category: Toxicology Authors: Zhangjian Chen, Di Zhou, Shuo Han, Shupei Zhou and Guang Jia Tags: Research Source Type: research
Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles
Zinc oxide nanoparticles (ZnO-NPs) are widely used in many industrial sectors and previous studies have reported that exposure of the lungs to ZnO-NPs induces both acute and/or chronic pulmonary inflammation, ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 16, 2019 Category: Toxicology Authors: Radwa Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Cai Zong, Ken Itoh, Masayuki Yamamoto, Ahmed Ali Elsayed, Soheir El-Bestar, Emily Kamel and Gaku Ichihara Tags: Research Source Type: research
Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies
Silver nanoparticles (AgNPs), as promising anti-microbials and anti-cancer therapeutics, the toxicological effect and killing efficiency towards cells need in-depth investigation for better applications in dai... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 27, 2019 Category: Toxicology Authors: Ming Xu, Qiuyuan Yang, Lining Xu, Ziyu Rao, Dong Cao, Ming Gao and Sijin Liu Tags: Research Source Type: research
Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer ’s disease mice
A growing body of epidemiological literature indicates that particulate matter (PM) air pollution exposure is associated with elevated Alzheimer ’s disease (AD) risk and may exacerbate AD-related cognitive decl... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 26, 2019 Category: Toxicology Authors: Katrina Jew, Denise Herr, Candace Wong, Andrea Kennell, Keith Morris-Schaffer, G ünter Oberdörster, M. Kerry O’Banion, Deborah A. Cory-Slechta and Alison Elder Tags: Research Source Type: research
