Food-grade titanium dioxide and zinc oxide nanoparticles induce toxicity and cardiac damage after oral exposure in rats
Metallic nanoparticles (NPs) are widely used as food additives for human consumption. NPs reach the bloodstream given their small size, getting in contact with all body organs and cells. NPs have adverse effec... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 17, 2023 Category: Toxicology Authors: Manuel Alejandro Herrera-Rodr íguez, María del Pilar Ramos-Godinez, Agustina Cano-Martínez, Francisco Correa Segura, Angélica Ruiz-Ramírez, Natalia Pavón, Elizabeth Lira-Silva, Rocío Bautista-Pérez, Rosina Sánchez Thomas, Norma Laura Delgado-Buen Tags: Research Source Type: research
Heterogeneous deposition of regular and mentholated little cigar smoke in the lungs of Sprague-Dawley rats
Quantifying the dose and distribution of tobacco smoke in the respiratory system is critical for understanding its toxicity, addiction potential, and health impacts. Epidemiologic studies indicate that the inc... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 6, 2023 Category: Toxicology Authors: Kaisen Lin, Christopher Wallis, Emily M. Wong, Patricia Edwards, Austin Cole, Laura Van Winkle and Anthony S. Wexler Tags: Research Source Type: research
High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages
Epidemiological studies have demonstrated that individuals with preexisting conditions, including diabetes mellitus (DM), are more susceptible to air pollution. However, the underlying mechanisms remain unclea... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 2, 2023 Category: Toxicology Authors: Yiqun Mo, Luke Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan and Qunwei Zhang Tags: Research Source Type: research
An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models
The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few e... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 24, 2023 Category: Toxicology Authors: Jenny Rissler, Madeleine Peterson Sj ögren, Julia Linell, Amalia Larsson Hurtig, Per Wollmer and Jakob Löndahl Tags: Research Source Type: research
Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model
Epidemiological studies have related desert dust events to increased respiratory morbidity and mortality. Although the Sahara is the largest source of desert dust, Saharan dust (SD) has been barely examined in... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 20, 2023 Category: Toxicology Authors: Gerrit Bredeck, Jochen Dobner, Burkhard Stahlmecke, Khanneh Wadinga Fomba, Hartmut Herrmann, Andrea Rossi and Roel P. F. Schins Tags: Research Source Type: research
The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles
Recently, mesoporous nanomaterials with widespread applications have attracted great interest in the field of drug delivery due to their unique structure and good physiochemical properties. As a biomimetic nan... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 8, 2023 Category: Toxicology Authors: Bang-Yao Chen, Si-Ying Hong, Han-Min Wang, Yi Shi, Peng Wang, Xiao-Juan Wang, Qian-Yang Jiang, Ke-Da Yang, Wei Chen and Xiao-Ling Xu Tags: Comment Source Type: research
Difference in carcinogenicities of two different vapor grown carbon fibers with different physicochemical characteristics induced by intratracheal instillation in rats
Carbon fibers are high aspect ratio structures with diameters on the submicron scale. Vapor grown carbon fibers are contained within multi-walled carbon tubes, with VGCF ™-H commonly applied as a conductive add... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 28, 2023 Category: Toxicology Authors: Kei Sato, Hiroko Fukui, Yuji Hagiwara, Ryoji Ogawa, Ayako Nishioka, Takamasa Numano, Taiki Sugiyama, Mayumi Kawabe, Yukinori Mera and Tadashi Yoneda Tags: Research Source Type: research
Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models
Limbal stem/progenitor cells (LSPCs) play a crucial role in maintaining corneal health by regulating epithelial homeostasis. Although PM2.5 is associated with the occurrence of several corneal diseases, its ef... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 27, 2023 Category: Toxicology Authors: Shengjie Hao, Zhijian Chen, Yuzhou Gu, Lu Chen, Feiyin Sheng, Yili Xu, Di Wu, Yu Han, Bing Lu, Shuying Chen, Wei Zhao, Houfa Yin, Xiaofeng Wang, S. Amer Riazuddin, Xiaoming Lou, Qiuli Fu & hellip; Tags: Research Source Type: research
Long-term exposure to polystyrene microplastics triggers premature testicular aging
Plastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans health. The accumulation of MPs in the tissues and blood in animals and h... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 28, 2023 Category: Toxicology Authors: Deyi Wu, Meng Zhang, Ting Ting Bao and Hainan Lan Tags: Research Source Type: research
Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments
With the large-scale production and application of amorphous silica nanoparticles (aSiNPs), its adverse health effects are more worthy of our attention. Our previous research has demonstrated for the first tim... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 22, 2023 Category: Toxicology Authors: Liyan Xiao, Jinyan Pang, Hua Qin, Liyang Dou, Man Yang, Ji Wang, Xianqing Zhou, Yang Li, Junchao Duan and Zhiwei Sun Tags: Research Source Type: research
Effect of sp3/sp2 carbon ratio and hydrodynamic size on the biodistribution kinetics of nanodiamonds in mice via intravenous injection
Nanodiamonds (NDs) have gained a rapidly growing interest in biomedical applications; however, little is known regarding their biokinetics owing to difficulties in measurements and limited synthesis/purificati... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 21, 2023 Category: Toxicology Authors: Jiyoung Jeong, Soyeon Jeon, Songyeon Kim, Sinuk Lee, Gyuri Kim, Eunsol Bae, Yeonjeong Ha, Seung Whan Lee, Ji-Su Kim, Dong-Jae Kim and Wan-Seob Cho Tags: Research Source Type: research
Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes
Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) has been reported to exert strong pro-inflammatory and pro-fibrotic adjuvant effects in mouse models of allergic lung disease. However, the molecula... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 14, 2023 Category: Toxicology Authors: Ho Young Lee, Dorothy J. You, Alexia Taylor-Just, Logan J. Tisch, Ryan D. Bartone, Hannah M. Atkins, Lauren M. Ralph, Silvio Antoniak and James C. Bonner Tags: Research Source Type: research
Role of different mechanisms in pro-inflammatory responses triggered by traffic-derived particulate matter in human bronchiolar epithelial cells
Traffic-derived particles are important contributors to the adverse health effects of ambient particulate matter (PM). In Nordic countries, mineral particles from road pavement and diesel exhaust particles (DE... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 3, 2023 Category: Toxicology Authors: Magne Refsnes, Tonje Skuland, Rikke J ørgensen, Vegard Sæter-Grytting, Brynhild Snilsberg, Johan Øvrevik, Jørn A. Holme and Marit Låg Tags: Research Source Type: research
Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans
Exposure to wood smoke has been shown to contribute to adverse respiratory health effects including airway infections, but the underlying mechanisms are unclear. A preceding study failed to confirm any acute i... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 31, 2023 Category: Toxicology Authors: Alva Hansson, Gregory Rankin, Oskari Uski, Maria Friberg, Jamshid Pourazar, Robert Lindgren, Natxo Garc ía-López, Christoffer Boman, Thomas Sandström, Annelie Behndig and Ala Muala Tags: Research Source Type: research
Single-cell transcriptome sequencing –based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis
Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools. Epithelial mesenchymal transi... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 19, 2023 Category: Toxicology Authors: Shaoqi Yang, Yuheng Sun, Min Long, Xinbei Zhou, Mengqin Yuan, Liliang Yang, Wei Luo, Yusi Cheng, Xinxin Zhang, Wei Jiang and Jie Chao Tags: Research Source Type: research
