Nanomaterial- and shape-dependency of TLR2 and TLR4 mediated signaling following pulmonary exposure to carbonaceous nanomaterials in mice
Pulmonary exposure to high doses of engineered carbonaceous nanomaterials (NMs) is known to trigger inflammation in the lungs paralleled by an acute phase response. Toll-like receptors (TLRs), particularly TLR... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 30, 2021 Category: Toxicology Authors: Pernille H øgh Danielsen, Katja Maria Bendtsen, Kristina Bram Knudsen, Sarah Søs Poulsen, Tobias Stoeger and Ulla Vogel Tags: Research Source Type: research
Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials
Growing industrial use of carbon nanotubes and nanofibers (CNT/F) warrants consideration of human health outcomes. CNT/F produces pulmonary, cardiovascular, and other toxic effects in animals along with a sign... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 28, 2021 Category: Toxicology Authors: Ekaterina Mostovenko, Matthew M. Dahm, Mary K. Schubauer-Berigan, Tracy Eye, Aaron Erdely, Tamara L. Young, Matthew J. Campen and Andrew K. Ottens Tags: Research Source Type: research
Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study
Silver nanoparticles (AgNPs) are widely used in biomedicine due to their strong antimicrobial, antifungal, and antiviral activities. Concerns about their possible negative impacts on human and environmental he... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 18, 2021 Category: Toxicology Authors: Marija Ćurlin, Rinea Barbir, Sanja Dabelić, Marija Ljubojević, Walter Goessler, Vedran Micek, Irena Žuntar, Mirela Pavić, Lucija Božičević, Ivan Pavičić and Ivana Vinković Vrček Tags: Research Source Type: research
The mechanism of cell death induced by silver nanoparticles is distinct from silver cations
Precisely how silver nanoparticles (AgNPs) kill mammalian cells still is not fully understood. It is not clear if AgNP-induced damage differs from silver cation (Ag+), nor is it known how AgNP damage is transmitt... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 14, 2021 Category: Toxicology Authors: Monica M. Rohde, Christina M. Snyder, John Sloop, Shane R. Solst, George L. Donati, Douglas R. Spitz, Cristina M. Furdui and Ravi Singh Tags: Research Source Type: research
Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages
Considering the inevitability for humans to be frequently exposed to nanoparticles (NPs), understanding the biosafety of NPs is important for rational usage. As an important part of the innate immune system, m... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 26, 2021 Category: Toxicology Authors: Xiaoting Jin, Haiyi Yu, Ze Zhang, Tenglong Cui, Qi Wu, Xiaolei Liu, Jie Gao, Xingchen Zhao, Jianbo Shi, Guangbo Qu and Guibin Jiang Tags: Research Source Type: research
Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation
Multiwalled carbon nanotubes (MWCNT) are an increasingly utilized engineered nanomaterial that pose the potential for significant risk of exposure-related health outcomes. The mechanism(s) underlying MWCNT-ind... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 8, 2021 Category: Toxicology Authors: Tamara L. Young, Ekaterina Mostovenko, Jesse L. Denson, Jessica G. Begay, Selita N. Lucas, Guy Herbert, Katherine Zychowski, Russell Hunter, Raul Salazar, Ting Wang, Kelly Fraser, Aaron Erdely, Andrew K. Ottens and Matthew J. Campen Tags: Research Source Type: research
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
Today, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability. (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 8, 2021 Category: Toxicology Authors: Ponnusamy Manogaran Gopinath, Krishna Sundar Twayana, Palaniyandi Ravanan, John Thomas, Amitava Mukherjee, David F. Jenkins and Natarajan Chandrasekaran Tags: Research Source Type: research
Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion
Metal oxide nanoparticles (NPs) are increasingly used in many industrial and biomedical applications, hence their impact on occupational and public health has become a concern. In recent years, interest on the... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 3, 2021 Category: Toxicology Authors: Antonella Camaioni, Micol Massimiani, Valentina Lacconi, Andrea Magrini, Antonietta Salustri, Georgios A. Sotiriou, Dilpreet Singh, Dimitrios Bitounis, Beatrice Bocca, Anna Pino, Flavia Barone, Valentina Prota, Ivo Iavicoli, Manuel Scimeca, Elena Bonanno, Tags: Research Source Type: research
Safe by design (SbD) and nanotechnology: a much-discussed topic with a prudence?
Safe-by-Design (SbD) has been put forward as a concept to assure that only safe nanomaterials will reach the market and that safety aspects have already been considered in a very early stage of the innovation ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 23, 2021 Category: Toxicology Authors: Mary Gulumian and Flemming R. Cassee Tags: Editorial Source Type: research
Cytotoxicity analysis of biomass combustion particles in human pulmonary alveolar epithelial cells on an air –liquid interface/dynamic culture platform
This study investigated the cytotoxicity and molecular mechanisms of biomass combustion-derived particle... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 21, 2021 Category: Toxicology Authors: Shaorui Ke, Qi Liu, Xinlian Zhang, Yuhan Yao, Xudong Yang and Guodong Sui Tags: Research Source Type: research
Silica-coated magnetic nanoparticles activate microglia and induce neurotoxic d-serine secretion
Nanoparticles have been studied for brain imaging, diagnosis, and drug delivery owing to their versatile properties due to their small sizes. However, there are growing concerns that nanoparticles may exert to... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 12, 2021 Category: Toxicology Authors: Tae Hwan Shin, Da Yeon Lee, Balachandran Manavalan, Shaherin Basith, Yun-Cheol Na, Cheolho Yoon, Hyeon-Seong Lee, Man Jeong Paik and Gwang Lee Tags: Research Source Type: research
Retained particle surface area dose drives inflammation in rat lungs following acute, subacute, and subchronic inhalation of nanomaterials
An important aspect of nanomaterial (NM) risk assessment is establishing relationships between physicochemical properties and key events governing the toxicological pathway leading to adverse outcomes. The dif... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 5, 2021 Category: Toxicology Authors: Fr édéric Cosnier, Carole Seidel, Sarah Valentino, Otmar Schmid, Sébastien Bau, Ulla Vogel, Jérôme Devoy and Laurent Gaté Tags: Research Source Type: research
Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells
Expanding biomedical application of anatase titanium dioxide (TiO2) nanoparticles (NPs) is raising the public concern on its potential health hazards. Here, we demonstrated that TiO2 NPs can increase phosphatidyl... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 4, 2021 Category: Toxicology Authors: Yiying Bian, Han-Young Chung, Ok-Nam Bae, Kyung-Min Lim, Jin-Ho Chung and Jingbo Pi Tags: Research Source Type: research
Effects of water-soluble components of atmospheric particulates from rare earth mining areas in China on lung cancer cell cycle
This study aims to investigate the effects of water soluble particulate matter (WSPM) on the viability and protein expression profile of human lung adenocarcinoma cell A549 in the Bayou Obo rare earth mining a... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 2, 2021 Category: Toxicology Authors: Yuan Xia, Xulong Zhang, Dejun Sun, Yumin Gao, Xiaoe Zhang, Li Wang, Qingjun Cai, Qihao Wang and Juan Sun Tags: Research Source Type: research
Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer
The gastrointestinal tract is a complex interface between the external environment and the immune system. Its ability to control uptake across the mucosa and to protect the body from damage of harmful substanc... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - July 30, 2021 Category: Toxicology Authors: Fr édérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand and Marie Carriere Tags: Review Source Type: research
