Grouping of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment
Nanomaterials can exist in different nanoforms (NFs). Their grouping may be supported by the formulation of hypotheses which can be interrogated via integrated approaches to testing and assessment (IATA). IATA... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 2, 2022 Category: Toxicology Authors: Luisana Di Cristo, Victor C. Ude, Georgia Tsiliki, Giuseppina Tatulli, Alessio Romaldini, Fiona Murphy, Wendel Wohlleben, Agnes G. Oomen, Pier P. Pompa, Josje Arts, Vicki Stone and Stefania Sabella Tags: Research Source Type: research
A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence
The impacts of air pollution on public health have become a great concern worldwide. Ambient particulate matter (PM) is a major air pollution that comprises a heterogeneous mixture of different particle sizes ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 29, 2022 Category: Toxicology Authors: Tianyu Li, Yang Yu, Zhiwei Sun and Junchao Duan Tags: Review Source Type: research
Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study
Traffic-related air pollution (TRAP) exposure causes adverse effects on wellbeing and quality of life, which can be studied non-invasively using self-reported symptoms. However, little is known about the effec... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - November 23, 2022 Category: Toxicology Authors: Juma Orach, Christopher Francis Rider, Agnes Che Yan Yuen and Christopher Carlsten Tags: Research Source Type: research
Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation
Exposure to particulate matter air pollution is associated with an increased risk of cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are no... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 24, 2022 Category: Toxicology Authors: Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu and Tong Zhu Tags: Research Source Type: research
Toxicokinetic study following intratracheal instillation or oral gavage of two [7Be]-tagged carbon black samples
The toxicokinetic behaviour of nanostructured particles following pulmonary or oral deposition is of great scientific interest. In this toxicokinetic study, following the general principles of OECD TG 417, the... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 14, 2022 Category: Toxicology Authors: Otto Creutzenberg, Volker Hammann, Stefanie Wolf, J ürgen Daul, Yufanyi Ngiewih, Ishrat Chaudhuri and Len Levy Tags: Research Source Type: research
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress
Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary dise... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - October 14, 2022 Category: Toxicology Authors: Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding and Zhongbing Lu Tags: Research Source Type: research
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile
A key aspect of any new material safety assessment is the evaluation of their in vivo genotoxicity. Graphene oxide (GO) has been studied for many promising applications, but there are remaining concerns about ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 21, 2022 Category: Toxicology Authors: Luis Augusto Visani de Luna, Thomas Loret, Alexander Fordham, Atta Arshad, Matthew Drummond, Abbie Dodd, Neus Lozano, Kostas Kostarelos and Cyrill Bussy Tags: Research Source Type: research
A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity
Exposure to air pollutants is one of the major environmental health risks faced by populations globally. Information about inhaled particle deposition dose is crucial in establishing the dose –response function... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 15, 2022 Category: Toxicology Authors: Leizel Madue ño, Simonas Kecorius, Jakob Löndahl, Jürgen Schnelle-Kreis, Alfred Wiedensohler and Mira Pöhlker Tags: Research Source Type: research
Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study
Most toxicological studies on titanium dioxide (TiO2) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and int... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 14, 2022 Category: Toxicology Authors: Shotaro Yamano, Yuko Goto, Tomoki Takeda, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo and Yumi Umeda Tags: Research Source Type: research
A systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective
The number of publications in the field of nanogenotoxicology and the amount of genotoxicity data on nanomaterials (NMs) in several databases generated by European Union (EU) funded projects have increased dur... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 14, 2022 Category: Toxicology Authors: Kirsi K. Siivola, Michael J. Burgum, Blanca Su árez-Merino, Martin J. D. Clift, Shareen H. Doak and Julia Catalán Tags: Review Source Type: research
Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats
Microplastics (MPs) and nanoplastics (NPs) formed from decomposed plastic are increasing environmental threats. Although MPs and NPs exposed through various routes enter the systemic circulation, the potential... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - September 14, 2022 Category: Toxicology Authors: Eun-Hye Kim, Sungbin Choi, Donghyun Kim, Han Jin Park, Yiying Bian, Sang Ho Choi, Han Young Chung and Ok-Nam Bae Tags: Research Source Type: research
Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring
Over the last two decades, nanotechnologies and the use of nanoparticles represent one of the greatest technological advances in many fields of human activity. Particles of titanium dioxide (TiO2) are one of the ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 18, 2022 Category: Toxicology Authors: Elo ïse Colnot, Laura Cardoit, Marie-Jeanne Cabirol, Lydia Roudier, Marie-Helene Delville, Anne Fayoux, Muriel Thoby-Brisson, Laurent Juvin and Didier Morin Tags: Research Source Type: research
The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice
Air pollution has been associated with neurodevelopmental disorders in epidemiological studies. In our studies in mice, developmental exposures to ambient ultrafine particulate (UFP) matter either postnatally ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 9, 2022 Category: Toxicology Authors: Marissa Sobolewski, Katherine Conrad, Elena Marvin, Matthew Eckard, Calla M. Goeke, Alyssa K. Merrill, Kevin Welle, Brian P. Jackson, Robert Gelein, David Chalupa, G ünter Oberdörster and Deborah A. Cory-Slechta Tags: Research Source Type: research
Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment
Metabolic syndrome (MetS) exacerbates susceptibility to inhalation exposures such as particulate air pollution, however, the mechanisms responsible remain unelucidated. Previously, we determined a MetS mouse m... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 6, 2022 Category: Toxicology Authors: Saeed Alqahtani, Li Xia and Jonathan H. Shannahan Tags: Research Source Type: research
Coronas of micro/nano plastics: a key determinant in their risk assessments
As an emerging pollutant in the life cycle of plastic products, micro/nanoplastics (M/NPs) are increasingly being released into the natural environment. Substantial concerns have been raised regarding the envi... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - August 6, 2022 Category: Toxicology Authors: Jiayu Cao, Qing Yang, Jie Jiang, Tatenda Dalu, Aliaksei Kadushkin, Joginder Singh, Rawil Fakhrullin, Fangjun Wang, Xiaoming Cai and Ruibin Li Tags: Review Source Type: research
