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L ‐Citrulline Ameliorates Iron Metabolism and Mitochondrial Quality Control via Activating AMPK Pathway in Intestine and Improves Microbiota in Mice with Iron Overload
ConclusionL-cit may restrain ferritinophagy and ferroptosis to regulate iron metabolism, and induce AMPK pathway activation, which contributes to exert antioxidation, ameliorate iron metabolism and mitochondrial quality control, and improve intestinal microbiota. L-cit is a promising therapeutic strategy for iron overload-induced intestinal injury. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - March 1, 2024 Category: Food Science Authors: Dai Zhao, Yuan Gao, Yiqin Chen, Yingsi Zhang, Yian Deng, Sai Niu, Hanchuan Dai Tags: Research Article Source Type: research

Front Cover: Gastro ‐Intestinal Digested Bovine Milk Osteopontin Modulates Gut Barrier Biomarkers In Vitro
Mol. Nutr. Food Res. 2024,68,2200777DOI:10.1002/mnfr.202200777The cover image is based on the Research ArticleGastro-Intestinal Digested Bovine Milk Osteopontin Modulates Gut Barrier Biomarkers In Vitro by Lu Li et al.,https://doi.org/10.1002/mnfr.202200777 (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 29, 2024 Category: Food Science Authors: Lu Li, Juchun Chen, Yuxing Zheng, Jonathan Lane, Ruibiao Hu, Jianzhong Zhu, Xiong Fu, Qiang Huang, Feitong Liu, Bin Zhang Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 4'24
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 29, 2024 Category: Food Science Tags: Editorial Board Source Type: research

Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO ‐1 Pathway
The main mechanism of Vc involves the antioxidant and prooxidant effects depended on the administration methods of Vc (p.o)/(i.v). The interaction between ROS and Nrf2/HO-1 expression induced DNA damage and DNA strand breakage, promoted H2AX phosphorylation, and induced cell apoptosis by activating cleaved caspases 3 and 9. AbstractAs an important nutritional component, vitamin C (Vc) shows good antitumor activity in a variety of cancer, but there are few studies in pulmonary metastasis. In order to verify its anticancer and antimetastatic effect, the study sets up H22 pulmonary metastasis mouse model. The results show tha...
Source: Molecular Nutrition and Food Research - February 29, 2024 Category: Food Science Authors: Shuli Man, Jingxian Bi, Furui Liu, Wenwen Xie, Long Ma Tags: Research Article Source Type: research

Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
The discovery of metabolically active brown adipose tissue (BAT) in adults and the global obesity epidemic have made BAT a therapeutic focus. BAT now has a new molecular signature, with identified molecules called batokines. Certain food compounds enhance BAT activation. This review covers BAT's physiology, its role in obesity, and food compounds that activate thermogenesis. AbstractThe discovery of metabolically active brown adipose tissue (BAT) in human adults and the worldwide increase in obesity and obesity-related chronic noncommunicable diseases (NCDs) has made BAT a therapeutic target in the last two decades. The po...
Source: Molecular Nutrition and Food Research - February 25, 2024 Category: Food Science Authors: Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza ‐Mello, Julio Beltrame Daleprane Tags: Review Source Type: research

Hypolipidemic  and Anti‐Obesity Effect of Anserine on Mice Orally Administered with High‐Fat Diet via Regulating SREBP‐1, NLRP3, and UCP‐1
This study describes that anserine can activate brown fat and increase the content of PGC1- α and UCP-1 proteins for anti-obesity action. Its mechanism of hypolipidemic and anti-obesity action may be to activate brown fat by inhibiting the NLRP3/NF-κB pathway protein secreting IL-1β. Thus, anserine may be a potential dietary supplement for decreasing blood fat and preventing obesity. AbstractTo investigate the efficacy of anserine on antiobesity, C57BL/6 mice are orally administered with a high-fat diet (HFD) and different doses of anserine (60, 120, and 240  mg/kg/day) for 16 weeks. Body weight, lipid, and epididymal ...
Source: Molecular Nutrition and Food Research - February 24, 2024 Category: Food Science Authors: Jing Luo, Ming Chen, Hongwu Ji, Weifeng Su, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu Tags: Research Article Source Type: research

Metabolomic Investigation of Brain and Liver in Rats Fed Docosahexaenoic Acid in Regio ‐ and Enantiopure Triacylglycerols
ConclusionThis study sheds light on the impact of stereospecific positioning of DHA in triacylglycerols and the role of dietary stearic acid on metabolism in the brain and liver. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 24, 2024 Category: Food Science Authors: Raghunath Pariyani, Yumei Zhang, Gudmundur G. Haraldsson, Kang Chen, Kaisa M. Linderborg, Baoru Yang Tags: Research Article Source Type: research

Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High ‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora
The article verified the mechanism of action of mud clam (Tegillarca granosa polysaccharide TGP) polysaccharide on NAFLD, an epidemic liver disease, through in vivo experiments in male C57BL/6 male mice. The main research content is as follows: mice were modeled with high-fat diet while intervening with TGP polysaccharide for 16 weeks, and at the end of the cycle, body weight, liver weight, serum biochemical indexes, pathological histomorphology, hepatic lipid accumulation, oxidative stress, and inflammation-related factors were observed and measured, and at the same time, the expression of genes and proteins related to th...
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Xingwen Yang, Shiwei Yao, Qihong Jiang, Hui Chen, Shulai Liu, Guoxin Shen, Xingwei Xiang, Lin Chen Tags: Research Article Source Type: research

Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells
ConclusionBesides structure –activity relationships, this study provides new information on the overall effects of steroidal alkaloids on intestinal cells and closes a gap of knowledge for the metabolic pathway from oral uptake to final excretion. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Lucas Keuter, Alessa Wolbeck, Matthias Kasimir, Lina Sch ürmann, Matthias Behrens, Hans‐Ulrich Humpf Tags: Research Article Source Type: research

Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls
ConclusionsAspartame reduces the chance of puberty occurring earlier than usual in female offspring and girls. Particularly, 60  mg kg−1 aspartame-fed female offspring delays pubertal onset through the dysregulation of HPG axis and GM composition by inhibiting the Kiss1/GPR54 system and inducing the RFRP-3. An acceptable dose of aspartame should be recommended during childhood. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Chia ‐Yuan Lin, Nam Nhat Nguyen, Wan‐Ling Tsai, Rong‐Hong Hsieh, Hung‐Tsung Wu, Yang‐Ching Chen Tags: Research Article Source Type: research

A Gently Processed Skim Milk ‐Derived Whey Protein Concentrate for Infant Formula: Effects on Gut Development and Immunity in Preterm Pigs
ConclusionThe gently processed SPC has more native protein, but higher MRP levels than WPC, resulting in similar tolerability but subclinical adverse gut effects in preterm pigs. Additional heat treatment and storage further induce MRP formation, gut inflammation, and intestinal mucosal damage. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Karoline Aasmul ‐Olsen, Halise Gül Akıllıoğlu, Line Iadsatian Christiansen, Kasper Engholm‐Keller, Anders Brunse, Denitsa Vladimirova Stefanova, Ann Bjørnshave, Mie Rostved Bechshøft, Kerstin Skovgaard, Thomas Thymann, Per Torp Sangild Tags: Research Article Source Type: research

Astragaloside IV Mitigated Diabetic Nephropathy by Restructuring Intestinal Microflora and Ferroptosis
Conclusion  Intestinal microbiome alterations and ferroptosis modulation by AS-IV may play instrumental roles in this mechanism, providing compelling evidence for the role of the gut-renal axis in DN. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Xin Lyu, Ting ‐ting Zhang, Zhen Ye, Ce Chen Tags: Research Article Source Type: research

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals
ConclusionsSeveral kawakawa compounds that are also widely found in other plants are bioavailable and are modified by phase 1 and 2 metabolism. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Ramya Jayaprakash, Chris Pook, Farha Ramzan, Jennifer L. Miles ‐Chan, Richard F. Mithen, Meika Foster Tags: Research Article Source Type: research

Effect of Aerobic Exercise and Time ‐Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High‐Fat Diet
ConclusionHFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Ghulam Shere Raza, Ya ğmur Kaya, Ville Stenbäck, Ravikant Sharma, Nalini Sodum, Shivaprakash Jagalur Mutt, Dominique D. Gagnon, Mikko Tulppo, Marjo‐Riitta Järvelin, Karl‐Heinz Herzig, Kari A. Mäkelä Tags: Research Article Source Type: research

Effect of l ‐Carnitine Supplementation on Osteoarthritis: A Systematic Review
ConclusionIn patients with OA,l-carnitine effectively decreases clinical signs and symptoms, inflammatory markers, pain, and stiffness indicators, and significantly improves WOMAC and VAS scores. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Haiyang Kou, Bo Li, Zhili Wang, Jianbing Ma Tags: Review Source Type: research