L ‐Citrulline Ameliorates Iron Metabolism and Mitochondrial Quality Control via Activating AMPK Pathway in Intestine and Improves Microbiota in Mice with Iron Overload

ConclusionL-cit may restrain ferritinophagy and ferroptosis to regulate iron metabolism, and induce AMPK pathway activation, which contributes to exert antioxidation, ameliorate iron metabolism and mitochondrial quality control, and improve intestinal microbiota. L-cit is a promising therapeutic strategy for iron overload-induced intestinal injury.

Source: Molecular Nutrition and Food Research - March 1, 2024 Category: Food Science Authors: Dai Zhao, Yuan Gao, Yiqin Chen, Yingsi Zhang, Yian Deng, Sai Niu, Hanchuan Dai Tags: Research Article Source Type: research