Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High ‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora

The article verified the mechanism of action of mud clam (Tegillarca granosa polysaccharide TGP) polysaccharide on NAFLD, an epidemic liver disease, through in vivo experiments in male C57BL/6 male mice. The main research content is as follows: mice were modeled with high-fat diet while intervening with TGP polysaccharide for 16 weeks, and at the end of the cycle, body weight, liver weight, serum biochemical indexes, pathological histomorphology, hepatic lipid accumulation, oxidative stress, and inflammation-related factors were observed and measured, and at the same time, the expression of genes and proteins related to the synthesis and metabolism of hepatic lipid and the effect of TGP on the composition and abundance of intestinal flora, and the expression of short-range bacteria were detected, as well as the effect of TGP on the intestinal tract of the mice. The effects of TGP on the composition and abundance of intestinal flora, the content of short-chain fatty acids and the correlation between intestinal flora and environmental factors were also examined. The results showed that the intake of TGP could effectively preclude the excessive accumulation of liver lipids, dyslipidemia, abnormal liver function and steatosis. Meanwhile, the intestinal flora of mice with NAFLD could be effectively regulated, and the diversity of the intestinal flora and the content of short-chain fatty acids could be increased, and the relative abundance of specific bacteria could be affected. Ab...
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research