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Egg Yolk Lipids Alleviated Dextran Sulfate Sodium ‐Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota
Anti-colitis mechanism of egg yolk lipids. AbstractThe increasing incidence of inflammatory bowel disease (IBD) has become a global phenomenon. Egg yolk lipids are one of the essential dietary foods, but its effects on intestinal immunity remain unclear. Here, egg yolk lipids are obtained using ethanol extraction and a total of 601 kinds of lipids are detected via lipidomics, including 251 kinds of triglycerides, 133 kinds of phosphatidylcholines, 44 kinds of phosphatidylethanolamines. Then, the study finds that egg yolk lipids significantly alleviate dextran sulfate sodium-induced colitis and reduce the production of infl...
Source: Molecular Nutrition and Food Research - December 1, 2023 Category: Food Science Authors: Nanhai Xiao, Wen He, Shuping Chen, Yao Yao, Na Wu, Mingsheng Xu, Huaying Du, Yan Zhao, Yonggang Tu Tags: Research Article Source Type: research

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway
ConclusionsLUT, a phyto-active component, protects against excessive intestinal motility and diarrhea by regulating the Nrf2 signaling pathway and effectively reduces oxidative stress damage in the colon. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - December 1, 2023 Category: Food Science Authors: Yuan Xia, Wei Tan, Fangting Yuan, Mengjuan Lin, Hesheng Luo Tags: Research Article Source Type: research

Front Cover: Does Flavonoid Supplementation Alleviate Non ‐Alcoholic Fatty Liver Disease? A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Mol. Nutr. Food Res. 2023,67,2300480DOI:10.1002/mnfr.202300480Higher flavonoid intake is associated with reduced risk of non-alcoholic fatty liver disease (NAFLD). The results of this systematic review and meta-analysis suggest that flavonoid supplementation contributes to the alleviation of NAFLD through exerting beneficial effects on liver function, lipid profile, and inflammation. Subgroup analysis reveals that dihydromyricetin and hesperidin demonstrate the most potency. This is reported by Lu Li, Kexin Ji, Fengqi Du, Nini Jin, Christine Boesch, Mohamed A. Farag, He Li, Xinqi Liu, and Jianbo Xiao in article number23004...
Source: Molecular Nutrition and Food Research - November 30, 2023 Category: Food Science Authors: Lu Li, Kexin Ji, Fengqi Du, Nini Jin, Christine Boesch, Mohamed A. Farag, He Li, Xinqi Liu, Jianbo Xiao Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 23'23
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 30, 2023 Category: Food Science Tags: Editorial Board Source Type: research

A High ‐Tryptophan Diet Alleviated Cognitive Impairment and Neuroinflammation in APP/PS1 Mice through Activating Aryl Hydrocarbon Receptor via the Regulation of Gut Microbiota
ConclusionsThese findings demonstrated that high-Trp diet exerts anti-inflammatory effects via upregulating AhR and suppressing NF- κB pathway, and its mechanisms may be mediated by regulating gut microbiota, suggesting that Trp diet may be a potential strategy for AD intervention. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 30, 2023 Category: Food Science Authors: Sipei Pan, Yuhe Zhang, Tao Ye, Yu Kong, Xiaorui Cui, Shushu Yuan, Jiaming Liu, Yang Zhang Tags: Research Article Source Type: research

Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine ‐Induced AD Animals
ConclusionsThe comprehensive process is helpful to the clinical application of WK as a promising cholinesterase inhibitors for nutritional intervention. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 29, 2023 Category: Food Science Authors: Xiajing Xu, Yutong Song, Man Jiang, Meihan Liu, Xuanmeng Zhang, Dongmei Wang, Yingni Pan, Shumeng Ren, Xiaoqiu Liu Tags: Research Article Source Type: research

Integrated Metabolomics and Gut Microbiome Analysis Reveals the Efficacy of a Phytochemical Constituent in the Management of Ulcerative Colitis
ConclusionsThese results indicate that CAH exerts a beneficial role in UC by synergistic modulating the balance in gut microbiota and the associated metabolites, and highlights the nutritional and medicinal value of CAH in UC management. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 28, 2023 Category: Food Science Authors: Kai Zhang, Jianbin Ji, Nana Li, Zhaorui Yin, Guanwei Fan Tags: Research Article Source Type: research

Maternal Vitamin D Deficiency in Mice Sex ‐Dependently Affects Hepatic Lipid Accumulation in Offspring
ConclusionMaternal VDD combined with a HF diet in male may predispose to hepatic hypertrophia, with a specific lipid profile. Such observations reinforce our knowledge of the impact of maternal VDD on hepatic programming in the offspring. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 27, 2023 Category: Food Science Authors: Nicole Haroun, Imene Bennour, Eva Seipelt, Julien Astier, L éa Sani, Catherine Tardivel, Ljubica Svilar, Jean‐Charles Martin, Lourdes Mounien, Jean François Landrier Tags: Research Article Source Type: research

pH Sensitive Quercetin Nanoparticles Ameliorate DSS ‐Induced Colitis in Mice by Colon‐Specific Delivery
ConclusionpH sensitive QCT nanoparticles can reduce inflammatory reaction, improve gut microbiota, and repair intestinal barrier by targeting colon, thus improving DSS induced colitis in mice, providing reference for the treatment of colitis. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 27, 2023 Category: Food Science Authors: Lechen Wang, Rongrong Fu, Ying Meng, Jingjie Liang, Wenqing Xue, Haitao Hu, Jing Meng, Min Zhang Tags: Research Article Source Type: research

Evaluation of Food Intake Biomarkers for Red Bell Peppers in Human Urine Based on HPLC ‐MS/MS Analysis
ConclusionsA correlation between an intake of red bell pepper and the urinary excretion of recently described potential biomarkers is observed. Due to large interindividual differences, it is reasonable to assume that at least the qualitative detection of the consumption of bell peppers and possibly allCapsicum fruits is feasible. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 27, 2023 Category: Food Science Authors: Mareike Schulz, Florian H übner, Hans‐Ulrich Humpf Tags: Research Article Source Type: research

Dietary Achievable Dose of Protocatechuic Acid, a Metabolite of Flavonoids, Inhibits High ‐Fat Diet‐Induced Obesity in Mice
ConclusionsDietary achievable dose of PCA attenuates HFD-induced adiposity, which is likely achieved by increasing fatty acid oxidation other than activating adipose thermogenesis. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 24, 2023 Category: Food Science Authors: Panying Xiang, Yushi Du, Guanyu Chen, Yihui Mao, Shuangshuang Li, Qing Li, Yuting Yang, Xueyu Li, Dongliang Wang Tags: Research Article Source Type: research

Front Cover: Deoxynivalenol Exposure Induced Colon Damage in Mice Independent of the Gut Microbiota
Mol. Nutr. Food Res. 2023,67,202300317DOI:10.1002/mnfr.202300317Deoxynivalenol (DON), the most common mycotoxin occurring in grain and grain products, can destroy the integrity of the colonic physical barrier and induce oxidative stress and apoptosis in the colon of mice with or without the existence of gut microbiota. Meanwhile, fecal microbiota transplantation did not show significant role of gut microbiota in DON-induced colon damage. This is reported by Wei Yang, in article number2300317. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 22, 2023 Category: Food Science Authors: Yuxiao Liao, Zhao Peng, Shiyin Xu, Zitong Meng, Dan Li, Xiaolei Zhou, Rui Zhang, Shaojun Shi, Liping Hao, Liegang Liu, Wei Yang Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 22'23
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 22, 2023 Category: Food Science Tags: Editorial Board Source Type: research

Docosahexaenoic Acid ‐Acylated Astaxanthin Monoester Ameliorates Amyloid‐β Pathology and Neuronal Damage by Restoring Autophagy in Alzheimer's Disease Models
ConclusionThe findings demonstrate that AST-DHA can rectify autophagic impairment in AD, and confer neuroprotection in A β-related pathology, which supports the future application of AST as an autophagic inducer for maintaining brain health. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 22, 2023 Category: Food Science Authors: Xiaoxu Wang, Yu Song, Peixu Cong, Zhigao Wang, Yanjun Liu, Jie Xu, Changhu Xue Tags: Research Article Source Type: research

Goat Milk Improves Glucose Metabolism in Type 2 Diabetic Mice and Protects Pancreatic β‐Cell Functions
ConclusionsGoat milk diet improves glucose homeostasis and pancreatic conditions of T2DM mice, in association with improved blood metabolite profiles and activation of pancreatic AKT pathway. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 22, 2023 Category: Food Science Authors: Xiaoying Chen, Zhifei Zhang, Huiming Niu, Xinmiao Tian, Huibin Tian, Weiwei Yao, Huanshan He, Huaiping Shi, Cong Li, Jun Luo Tags: Research Article Source Type: research