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Syringaresinol Alleviates Early Diabetic Retinopathy by Downregulating HIF ‐1α/VEGF via Activating Nrf2 Antioxidant Pathway
ConclusionIn summary, SYR suppresses oxidative stress via activating Nrf2 antioxidant pathway, which ameliorates retinal microvascular damage by downregulating HIF-1 α/VEGF, thereby alleviating early DR progression. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 15, 2024 Category: Food Science Authors: Chang Liu, Tianwei Cheng, Yufei Wang, Guangru Li, Yachen Wang, Wencong Tian, Lifeng Feng, Shengzheng Zhang, Yang Xu, Yang Gao, Jing Li, Jie Liu, Jianlin Cui, Jie Yan, Lei Cao, Zhongjie Pan, Zhi Qi, Liang Yang Tags: Research Article Source Type: research

Chicken Muscle ‐Derived ACE2‐Upregulating Peptide VVHPKESF Reduces Blood Pressure Associated with the ACE2/Ang (1‐7)/MasR Axis in Spontaneously Hypertensive Rats
ConclusionsPeptide V-F is the first ACE2-upregulating peptide, purified and fractionated from food proteins based on in vitro ACE2 upregulation, that reduces BP associated with the activation of ACE2/Ang (1-7)/MasR axis; the N-terminal moiety VVHPK may be responsible for the antihypertensive effect of V-F. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 15, 2024 Category: Food Science Authors: Hongbing Fan, Nan Shang, Sandra T. Davidge, Jianping Wu Tags: Research Article Source Type: research

Assessing the Gut Microbiota's Ability to Metabolize Oligomeric and Polymeric Flavan ‐3‐ols from Aronia and Cranberry
In this study, the capacity of 34 donors to metabolize polymeric B-type flavan-3-ols from aronia and oligomeric A-type flavan-3-ols from cranberry is investigated by in vitro fecal batch ferme ntations. Less than 1% of the flavan-3-ols from both sources are converted into microbial metabolites, such as phenyl-γ-valerolactones (PVLs). To further confirm this result, gut microbial metabolites from flavan-3-ols are quantified in urine samples collected from participants, before and after a 4-day supplementation of cranberry extract providing 82.3 mg of flavan-3-ols per day. No significant difference is observed in the urina...
Source: Molecular Nutrition and Food Research - February 14, 2024 Category: Food Science Authors: Jacob Lessard ‐Lord, Charlène Roussel, Valérie Guay, Yves Desjardins Tags: Research Article Source Type: research

Effects of Ferulic Acid on Cognitive Function: A Systematic Review
ConclusionOverall, results from studies employing disease models suggest that FA ameliorates induced cognitive decline in a time and dose-dependent manner. Similarly, studies in healthy animals show a beneficial effect of FA. However, further studies are required to determine the effects of FA on human cognitive function. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 12, 2024 Category: Food Science Authors: Yesim Karademir, Alan Mackie, Kieran Tuohy, Louise Dye Tags: Review Source Type: research

Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism ‐Associated Ophthalmopathy
This study used intermittent fasting (IF) and vitamin E (Vit.E)  supplementation to prevent hypothyroidism-associated ophthalmopathy. This study hypothesized that intermittent fasting-like diet regimens and vitamin supplementation should reduce the propagation of HAO by its antioxidant potential. In the present study, experimental animals are divided into five groups: normal, hypothyroidism control, dual, Vit. E, and IF. Hypothyroidism is generated in the experimental groups by taking propylthiouracil (PTU) for 24 days while also taking IF and Vit. E supplements. The hypothyroid-induced experimental animals demonstrated...
Source: Molecular Nutrition and Food Research - February 12, 2024 Category: Food Science Authors: Nirdesh Kumar, Ashmita Das, Nidhi Kumari, Geeta Singh, Urvashi Jain, Amrita Singh, Surendra H. Bodakhe Tags: Research Article Source Type: research

From Gut to Hormones: Unraveling the Role of Gut Microbiota in (Phyto)Estrogen Modulation in Health and Disease
Estrogens are C-18 steroid hormones which are synthesized majorly by ovaries. Circulating estrogens undergo phase I oxidative hepatic metabolism, leading to the formation of catechol estrogens such as 16-OH and 2-OH. Estrogen metabolites then undergo conjugation before biliary excretion. The enteric bacterial genes (estrobolome) in the intestine deconjugates estrogen, influencing reabsorption. The factors like age, diet, antibiotics affect estrobolome, causing dysbiosis. The ratio of 2-OH to 16-OH metabolites indicates estrogen-cancer risk. AbstractThe human gut microbiota regulates estrogen metabolism through the “estro...
Source: Molecular Nutrition and Food Research - February 12, 2024 Category: Food Science Authors: Nikki Kumari, Rashmi Kumari, Ankita Dua, Mona Singh, Roushan Kumar, Poonam Singh, Susan Duyar ‐Ayerdi, Sunila Pradeep, Akinyemi I. Ojesina, Roshan Kumar Tags: Review Source Type: research

Influence of Dietary Triacylglycerol Structure on the Accumulation of Docosahexaenoic Acid [22:6(n ‐3)] in Organs in a Short‐Term Feeding Trial with Mildly Omega‐3 Deficient Rats
ConclusionThese findings indicated a possible difference in the tissue accumulation and/or metabolic fate of DHA from thesn-1 andsn-3 positions of TAG. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 12, 2024 Category: Food Science Authors: Amruta Kulkarni, Kaisa M. Linderborg, Ai Zhao, Heikki Kallio, Gudmundur G. Haraldsson, Yumei Zhang, Baoru Yang Tags: Research Article Source Type: research

Allicin Promotes Glucose Uptake by Activating AMPK through CSE/H2S ‐Induced S‐Sulfhydration in a Muscle‐Fiber Dependent Way in Broiler Chickens
ConclusionThis study demonstrates that allicin induces AMPK S-sulfhydration and AMPK phosphorylation to promote glucose uptake via the CSE/H2S system in a muscle fiber-dependent manner. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 11, 2024 Category: Food Science Authors: Kelin Li, Victoria A. Uyanga, Xiaojuan Wang, Hongchao Jiao, Jingpeng Zhao, Yunlei Zhou, Haifang Li, Hai Lin Tags: Research Article Source Type: research

Isomaltulose Enhances GLP ‐1 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharose
ConclusionA snack containing ISO markedly enhances the release of the metabolically advantageous gut hormones PYY and GLP-1 and enhances GIP release in response to a subsequent complex meal. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 9, 2024 Category: Food Science Authors: Jiudan Zhang, Dominik Sonnenburg, Domenico Tric ò, Stefan Kabisch, Andrea Mari, Stephan Theis, Margrit Kemper, Olga Pivovarova‐Ramich, Sascha Rohn, Andreas F. H. Pfeiffer Tags: Research Article Source Type: research

The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High ‐Fat Diet‐Fed Mice
ConclusionsR. canina flesh dietary supplementation slows down the steatotic effect of a HFD at least in part through the regulation of the transcriptional activity of PPAR γ. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 9, 2024 Category: Food Science Authors: H èctor Sanz‐Lamora, Mariano Nicola‐Llorente, Daniel Torres‐Oteros, Albert Pérez‐Martí, Inass Aghziel, Julián Lozano‐Castellón, Anna Vallverdú‐Queralt, Sílvia Canudas, Pedro F. Marrero, Diego Haro, Joana Relat Tags: Research Article Source Type: research

Allergic Reaction to a Commercially Available Insect Snack Caused by House Cricket (Acheta domesticus) Tropomyosin
ConclusionThis case report suggests that cricket tropomyosin may be an elicitor of allergic reactions even in previously not allergic patients, although it cannot be excluded the patient reacted additionally to other ingredients of the snack. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 9, 2024 Category: Food Science Authors: Andrea Wangorsch, Annette Jamin, Jelena Spiric, Stefan Vieths, Stephan Scheurer, Vera Mahler, Silke C. Hofmann Tags: Short Communication Source Type: research

Inside Front Cover: Oral Troxerutin Alleviates Depression Symptoms in Mice by Modulating Gut Microbiota and Microbial Metabolism
Mol. Nutr. Food Res. 2024,68,2300603DOI:10.1002/mnfr.202300603The cover image is based on the Research ArticleOral Troxerutin Alleviates Depression Symptoms in Mice by Modulating Gut Microbiota and Microbial Metabolism by Zhi-fang Lan et al.,https://doi.org/10.1002/mnfr.202300603 (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 9, 2024 Category: Food Science Authors: Zhi ‐fang Lan, Wei Yao, Yi‐ci Xie, Wushisi Chen, Yin‐ying Zhu, Jia‐qi Chen, Xing‐yi Zhou, Jun‐qing Huang, Man‐si Wu, Jia‐xu Chen Tags: Inside Front Cover Source Type: research

Front Cover: Metabolites 13,14 ‐Dihydro‐15‐keto‐PGE2 Participates in Bifidobacterium animalis F1‐7 to Alleviate Opioid‐Induced Constipation by 5‐HT Pathway
Mol. Nutr. Food Res. 2024,68,2200846DOI:10.1002/mnfr.202200846The cover image is based on the Research ArticleMetabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway by Youyou Lu et al.,https://doi.org/10.1002/mnfr.202200846. Image Credit: Lanwei Zhang (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 9, 2024 Category: Food Science Authors: Youyou Lu, Xiaohong Zhou, Yeting Wu, Qingyu Cui, Xiaoying Tian, Huaxi Yi, Pimin Gong, Lanwei Zhang Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 3'24
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 9, 2024 Category: Food Science Tags: Editorial Board Source Type: research

Effect of Dietary Protein Intake from Different Sources on Maternal and Umbilical Cord Plasma Amino Acid Levels
ConclusionsThese findings suggest that dietary protein intakes from specific sources during pregnancy may affect maternal plasma levels of amino acids. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 8, 2024 Category: Food Science Authors: Rui Zhao, Xinzheng Wang, Hongjuan Liu, Shanshan Wang, Leilei Zhou, Ningning Cui, Shu Guo, Guoping Xiong, Xuefeng Yang, Ting Xiong, Liping Hao Tags: Research Article Source Type: research