Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs
J Immunol Res. 2023 Oct 9;2023:7944102. doi: 10.1155/2023/7944102. eCollection 2023.ABSTRACTMidkine (MK) and pleiotrophin (PTN) belong to the same family of cytokines. They have similar sequences and functions. Both have important roles in cellular proliferation, tumors, and diseases. They regulate and are expressed by some immune cells. We have recently demonstrated MK production by some human innate antigen-presenting cells (iAPCs), i.e., monocyte-derived dendritic cells (MDDCs) and macrophages stimulated through Toll-like receptor (TLR)-4, and plasmacytoid dendritic cells (pDCs) stimulated through TLR 7. While PTN produ...
Source: Journal of Immunology Research - October 18, 2023 Category: Allergy & Immunology Authors: Elias A Said Sumaya Al-Dughaishi Wadha Al-Hatmi Iman Al-Reesi Mohammed S Al-Balushi Atika Al-Bimani Juma Z Al-Busaidi Marwa Al-Riyami Murtadha Al-Khabori Salam Al-Kindi Francesco A Procopio Shadia Al-Sinawi Aliyaa Al-Ansari Crystal Y Koh Khalid Al-Naamani Source Type: research
The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome
CONCLUSION: These results suggested that IL-33 decreased in the liver and spleen tissues of MAS mice. Further results suggest that IL-33 and St2 knockout mice have no treatment potential in CpG-induced MAS. Thus, the IL-33/ST2 axis has little effect on the prognosis of CpG-induced MAS.PMID:37842289 | PMC:PMC10569892 | DOI:10.1155/2023/2689360 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 16, 2023 Category: Allergy & Immunology Authors: Yuanji Dong Rongfen Gao Kailin He Jixin Zhong Lingli Dong Source Type: research
Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy
J Immunol Res. 2023 Sep 27;2023:5309816. doi: 10.1155/2023/5309816. eCollection 2023.ABSTRACTRapid and accurate methods for the diagnosis of tuberculous pleurisy (TP) are urgently needed. Activation markers of tuberculosis (TB)-reactive T cells are considered promising for the diagnosis of active TB (ATB). Different activation indexes may play different roles in the progression of TB, but there are few reports on T cell activation indicators, except for HLA-DR. Hence, we evaluated the expression of early (CD25 and CD69) and late (CD134) activation markers on TB antigen-stimulated CD4+ T cells in populations with different ...
Source: Journal of Immunology Research - October 9, 2023 Category: Allergy & Immunology Authors: Hanlu Shi Liping Yang Fujie Zhang Yu Zhou Yonglie Zhou Source Type: research
Alterations in the "Gut-Liver Axis" on Rats with Immunological Hepatic Fibrosis
J Immunol Res. 2023 Sep 21;2023:5577850. doi: 10.1155/2023/5577850. eCollection 2023.ABSTRACTThere remains a lack of standard models that have all the characteristics of human diseases. Especially in immunological hepatic fibrosis, the bovine serum albumin (BSA)-induced liver fibrosis models have the same developmental mechanisms as human liver fibrosis models, but have received little attention. We standardized a BSA-induced liver fibrosis model in rats and thoroughly assessed its pathological characteristics. We also used 16S sequencing to assess homeostasis of the intestinal microflora of rats with BSA-induced liver fib...
Source: Journal of Immunology Research - October 2, 2023 Category: Allergy & Immunology Authors: Zhaoyao Qi Xinxin Qi Yuanhui Xu Hongguang Sun Dengfeng Li Jincun Liu Meili Cong Tao Liu Source Type: research
