sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway
J Immunol Res. 2023 Sep 20;2023:4877700. doi: 10.1155/2023/4877700. eCollection 2023.ABSTRACTGenetic factors play an important role in the pathogenesis of systemic lupus erythematosus (SLE), and abnormal Toll-like receptor (TLR) signaling pathways are closely related to the onset of SLE. In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the mechanism is still unclear. Here, we stimulated mouse peritoneal macrophages with different concentrations of lipopolysaccharide. The re...
Source: Journal of Immunology Research - September 29, 2023 Category: Allergy & Immunology Authors: Yatao Bao Meng Lian Yong Chen Xiaotian Gu Kunyu Cao Xiaoping Du Jiyu Ju Source Type: research
Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1
CONCLUSION: Our results suggested that FYB1 gene played important role in regulating self-renewal of T-ALL cells by activating IGLL1, representing a promising therapeutic target for T-ALL patients.PMID:37767202 | PMC:PMC10522422 | DOI:10.1155/2023/3804605 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 28, 2023 Category: Allergy & Immunology Authors: Kunlong Zhang Jun Lu Fang Fang Yongping Zhang Juanjuan Yu Yanfang Tao Wenyuan Liu Lihui Lu Zimu Zhang Xinran Chu Jianwei Wang Xiaolu Li Yuanyuan Tian Zhiheng Li Qian Li Xu Sang Li Ma Ningling Wang Jian Pan Shaoyan Hu Source Type: research
Dupilumab's Impact on Blood Parameters in Nasal Polyposis: 18-Month Follow-Up in Real Life
CONCLUSION: To the best of our knowledge, this is the first study to evaluate the impact of dupilumab on several blood parameters in patients receiving treatment for CRswNP. Further studies are needed to confirm our results and to understand the underlying immunological mechanisms.PMID:37745203 | PMC:PMC10516700 | DOI:10.1155/2023/4027701 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 25, 2023 Category: Allergy & Immunology Authors: Antonella Loperfido Andrea Ciofalo Carlo Cavaliere Elona Begvarfaj Francesca Cascone Giacomo Alfonzo Rosalba Cadeddu Stefano Millarelli Gianluca Bellocchi Antonio Greco Marco de Vincentiis Simonetta Masieri Source Type: research
Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer
CONCLUSION: Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.PMID:37719086 | PMC:PMC10505079 | DOI:10.1155/2023/2473075 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 18, 2023 Category: Allergy & Immunology Authors: Qianqian Wang Chunxaing Feng Yuchun Chen Tianming Peng Yong Li Kunlin Wu Xiaoyong Pu Hanzhong Chen Jiumin Liu Source Type: research
