EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses
J Immunol Res. 2023 Nov 24;2023:8883045. doi: 10.1155/2023/8883045. eCollection 2023.ABSTRACTAmphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to regulate the phagocytosis-induced cell death of monocytes in peripheral blood. AREG-dependent apoptotic signaling engages factors of the intrinsic and extrinsic apoptotic pathway, such as BCL-2, BCL-XL, and death ligand/receptor CD95/CD95L. Here, we tested the hypothesis that AREG influences costimulatory monocyte functions, which are crucial for T-cell responses. We found a stronger expression of AREG and EGFR in monocytes compared...
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Stephan Dreschers Christopher Platen Louise Oppermann Caitlin Doughty Andreas Ludwig Aaron Babendreyer Thorsten W Orlikowsky Source Type: research
Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis
CONCLUSIONS: We described the B-cell-related molecular landscape of RA synovium and constructed a molecular diagnostic model in RA. The three genes FAS, GPR183, and TFRC may be potential targets for clinical diagnosis and immunoregulatory therapy of RA.PMID:38046263 | PMC:PMC10693468 | DOI:10.1155/2023/9422990 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Jifeng Tang Jinfang Xia Huiming Sheng Jinpiao Lin Source Type: research
EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses
J Immunol Res. 2023 Nov 24;2023:8883045. doi: 10.1155/2023/8883045. eCollection 2023.ABSTRACTAmphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to regulate the phagocytosis-induced cell death of monocytes in peripheral blood. AREG-dependent apoptotic signaling engages factors of the intrinsic and extrinsic apoptotic pathway, such as BCL-2, BCL-XL, and death ligand/receptor CD95/CD95L. Here, we tested the hypothesis that AREG influences costimulatory monocyte functions, which are crucial for T-cell responses. We found a stronger expression of AREG and EGFR in monocytes compared...
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Stephan Dreschers Christopher Platen Louise Oppermann Caitlin Doughty Andreas Ludwig Aaron Babendreyer Thorsten W Orlikowsky Source Type: research
Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis
CONCLUSIONS: We described the B-cell-related molecular landscape of RA synovium and constructed a molecular diagnostic model in RA. The three genes FAS, GPR183, and TFRC may be potential targets for clinical diagnosis and immunoregulatory therapy of RA.PMID:38046263 | PMC:PMC10693468 | DOI:10.1155/2023/9422990 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Jifeng Tang Jinfang Xia Huiming Sheng Jinpiao Lin Source Type: research
EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses
J Immunol Res. 2023 Nov 24;2023:8883045. doi: 10.1155/2023/8883045. eCollection 2023.ABSTRACTAmphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to regulate the phagocytosis-induced cell death of monocytes in peripheral blood. AREG-dependent apoptotic signaling engages factors of the intrinsic and extrinsic apoptotic pathway, such as BCL-2, BCL-XL, and death ligand/receptor CD95/CD95L. Here, we tested the hypothesis that AREG influences costimulatory monocyte functions, which are crucial for T-cell responses. We found a stronger expression of AREG and EGFR in monocytes compared...
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Stephan Dreschers Christopher Platen Louise Oppermann Caitlin Doughty Andreas Ludwig Aaron Babendreyer Thorsten W Orlikowsky Source Type: research
Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis
CONCLUSIONS: We described the B-cell-related molecular landscape of RA synovium and constructed a molecular diagnostic model in RA. The three genes FAS, GPR183, and TFRC may be potential targets for clinical diagnosis and immunoregulatory therapy of RA.PMID:38046263 | PMC:PMC10693468 | DOI:10.1155/2023/9422990 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Jifeng Tang Jinfang Xia Huiming Sheng Jinpiao Lin Source Type: research
EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses
J Immunol Res. 2023 Nov 24;2023:8883045. doi: 10.1155/2023/8883045. eCollection 2023.ABSTRACTAmphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to regulate the phagocytosis-induced cell death of monocytes in peripheral blood. AREG-dependent apoptotic signaling engages factors of the intrinsic and extrinsic apoptotic pathway, such as BCL-2, BCL-XL, and death ligand/receptor CD95/CD95L. Here, we tested the hypothesis that AREG influences costimulatory monocyte functions, which are crucial for T-cell responses. We found a stronger expression of AREG and EGFR in monocytes compared...
Source: Journal of Immunology Research - December 4, 2023 Category: Allergy & Immunology Authors: Stephan Dreschers Christopher Platen Louise Oppermann Caitlin Doughty Andreas Ludwig Aaron Babendreyer Thorsten W Orlikowsky Source Type: research
Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4)
In conclusion, Sestrin2 alleviates PF and endoplasmic reticulum stress-dependent ferroptosis through the NRF2/ATF4 pathway.PMID:38023615 | PMC:PMC10645490 | DOI:10.1155/2023/9439536 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Zhaoxing Dong Ting Li Cenli Wang Yong Zhou Zhongkai Tong Xuekui Du Source Type: research
Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy
J Immunol Res. 2023 Nov 9;2023:5599660. doi: 10.1155/2023/5599660. eCollection 2023.ABSTRACTThe clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) are decondensed chromatin extruded by neutrophils and are widely distributed among various cancers, such as pancreatic cancer, breast cancer, and hepatocellular carcinoma. In the TME, NETs interact with stromal components, immune cells and cancer cells, which allows for the reshaping of the matrix and the extracellular environment that favors the in...
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Hao Zuo Mengjie Yang Qian Ji Shengqiao Fu Xi Pu Xu Zhang Xu Wang Source Type: research
Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4)
In conclusion, Sestrin2 alleviates PF and endoplasmic reticulum stress-dependent ferroptosis through the NRF2/ATF4 pathway.PMID:38023615 | PMC:PMC10645490 | DOI:10.1155/2023/9439536 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Zhaoxing Dong Ting Li Cenli Wang Yong Zhou Zhongkai Tong Xuekui Du Source Type: research
Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy
J Immunol Res. 2023 Nov 9;2023:5599660. doi: 10.1155/2023/5599660. eCollection 2023.ABSTRACTThe clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) are decondensed chromatin extruded by neutrophils and are widely distributed among various cancers, such as pancreatic cancer, breast cancer, and hepatocellular carcinoma. In the TME, NETs interact with stromal components, immune cells and cancer cells, which allows for the reshaping of the matrix and the extracellular environment that favors the in...
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Hao Zuo Mengjie Yang Qian Ji Shengqiao Fu Xi Pu Xu Zhang Xu Wang Source Type: research
Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4)
In conclusion, Sestrin2 alleviates PF and endoplasmic reticulum stress-dependent ferroptosis through the NRF2/ATF4 pathway.PMID:38023615 | PMC:PMC10645490 | DOI:10.1155/2023/9439536 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Zhaoxing Dong Ting Li Cenli Wang Yong Zhou Zhongkai Tong Xuekui Du Source Type: research
Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy
J Immunol Res. 2023 Nov 9;2023:5599660. doi: 10.1155/2023/5599660. eCollection 2023.ABSTRACTThe clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) are decondensed chromatin extruded by neutrophils and are widely distributed among various cancers, such as pancreatic cancer, breast cancer, and hepatocellular carcinoma. In the TME, NETs interact with stromal components, immune cells and cancer cells, which allows for the reshaping of the matrix and the extracellular environment that favors the in...
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Hao Zuo Mengjie Yang Qian Ji Shengqiao Fu Xi Pu Xu Zhang Xu Wang Source Type: research
Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4)
In conclusion, Sestrin2 alleviates PF and endoplasmic reticulum stress-dependent ferroptosis through the NRF2/ATF4 pathway.PMID:38023615 | PMC:PMC10645490 | DOI:10.1155/2023/9439536 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Zhaoxing Dong Ting Li Cenli Wang Yong Zhou Zhongkai Tong Xuekui Du Source Type: research
Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy
J Immunol Res. 2023 Nov 9;2023:5599660. doi: 10.1155/2023/5599660. eCollection 2023.ABSTRACTThe clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) are decondensed chromatin extruded by neutrophils and are widely distributed among various cancers, such as pancreatic cancer, breast cancer, and hepatocellular carcinoma. In the TME, NETs interact with stromal components, immune cells and cancer cells, which allows for the reshaping of the matrix and the extracellular environment that favors the in...
Source: Journal of Immunology Research - November 29, 2023 Category: Allergy & Immunology Authors: Hao Zuo Mengjie Yang Qian Ji Shengqiao Fu Xi Pu Xu Zhang Xu Wang Source Type: research
