Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
J Immunol Res. 2023 Aug 31;2023:7625817. doi: 10.1155/2023/7625817. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occ...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Hui-Yuan Li Li-Feng Huang Xiao-Rong Huang Dan Wu Xiao-Cui Chen Ji-Xin Tang Ning An Hua-Feng Liu Chen Yang Source Type: research
Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia < em > In Vitro < /em >
J Immunol Res. 2023 Aug 31;2023:5595949. doi: 10.1155/2023/5595949. eCollection 2023.ABSTRACTMacrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Ivan Mikhailovich Rashchupkin Ekaterina Yakovlevna Shevela Aleksandra Aleksandrovna Maksimova Marina Aleksandrovna Tikhonova Aleksandr Anatolevich Ostanin Elena Removna Chernykh Source Type: research
Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
J Immunol Res. 2023 Aug 31;2023:7625817. doi: 10.1155/2023/7625817. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occ...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Hui-Yuan Li Li-Feng Huang Xiao-Rong Huang Dan Wu Xiao-Cui Chen Ji-Xin Tang Ning An Hua-Feng Liu Chen Yang Source Type: research
Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia < em > In Vitro < /em >
J Immunol Res. 2023 Aug 31;2023:5595949. doi: 10.1155/2023/5595949. eCollection 2023.ABSTRACTMacrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Ivan Mikhailovich Rashchupkin Ekaterina Yakovlevna Shevela Aleksandra Aleksandrovna Maksimova Marina Aleksandrovna Tikhonova Aleksandr Anatolevich Ostanin Elena Removna Chernykh Source Type: research
Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
J Immunol Res. 2023 Aug 31;2023:7625817. doi: 10.1155/2023/7625817. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occ...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Hui-Yuan Li Li-Feng Huang Xiao-Rong Huang Dan Wu Xiao-Cui Chen Ji-Xin Tang Ning An Hua-Feng Liu Chen Yang Source Type: research
Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia < em > In Vitro < /em >
J Immunol Res. 2023 Aug 31;2023:5595949. doi: 10.1155/2023/5595949. eCollection 2023.ABSTRACTMacrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Ivan Mikhailovich Rashchupkin Ekaterina Yakovlevna Shevela Aleksandra Aleksandrovna Maksimova Marina Aleksandrovna Tikhonova Aleksandr Anatolevich Ostanin Elena Removna Chernykh Source Type: research
Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
J Immunol Res. 2023 Aug 31;2023:7625817. doi: 10.1155/2023/7625817. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occ...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Hui-Yuan Li Li-Feng Huang Xiao-Rong Huang Dan Wu Xiao-Cui Chen Ji-Xin Tang Ning An Hua-Feng Liu Chen Yang Source Type: research
Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia < em > In Vitro < /em >
J Immunol Res. 2023 Aug 31;2023:5595949. doi: 10.1155/2023/5595949. eCollection 2023.ABSTRACTMacrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Ivan Mikhailovich Rashchupkin Ekaterina Yakovlevna Shevela Aleksandra Aleksandrovna Maksimova Marina Aleksandrovna Tikhonova Aleksandr Anatolevich Ostanin Elena Removna Chernykh Source Type: research
Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
J Immunol Res. 2023 Aug 31;2023:7625817. doi: 10.1155/2023/7625817. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occ...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Hui-Yuan Li Li-Feng Huang Xiao-Rong Huang Dan Wu Xiao-Cui Chen Ji-Xin Tang Ning An Hua-Feng Liu Chen Yang Source Type: research
Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia < em > In Vitro < /em >
J Immunol Res. 2023 Aug 31;2023:5595949. doi: 10.1155/2023/5595949. eCollection 2023.ABSTRACTMacrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Ivan Mikhailovich Rashchupkin Ekaterina Yakovlevna Shevela Aleksandra Aleksandrovna Maksimova Marina Aleksandrovna Tikhonova Aleksandr Anatolevich Ostanin Elena Removna Chernykh Source Type: research
Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
J Immunol Res. 2023 Aug 31;2023:7625817. doi: 10.1155/2023/7625817. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occ...
Source: Journal of Immunology Research - September 11, 2023 Category: Allergy & Immunology Authors: Hui-Yuan Li Li-Feng Huang Xiao-Rong Huang Dan Wu Xiao-Cui Chen Ji-Xin Tang Ning An Hua-Feng Liu Chen Yang Source Type: research
Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto's Thyroiditis
J Immunol Res. 2023 Aug 25;2023:5221658. doi: 10.1155/2023/5221658. eCollection 2023.ABSTRACTT helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto's thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early pregnancy or in patients with HT. The aim of the study was to measure autoantibodies to inflammatory-, Th1- and Th22-cytokines in seru...
Source: Journal of Immunology Research - September 4, 2023 Category: Allergy & Immunology Authors: Szabina Erd ő-Bonyár Di ána Simon Anna Bajnok Jasper N örenberg T ímea Serény-Litvai Ákos Várnagy K álmán Kovács Eszter Hantosi Emese Mez ősi T ímea Berki Source Type: research
Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NF < em > κ < /em > B Signal in Mice
J Immunol Res. 2023 Aug 24;2023:1116841. doi: 10.1155/2023/1116841. eCollection 2023.ABSTRACTAcetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in severe cases by triggering an inflammatory response and oxidative stress. Sesamin has been reported to possess anti-inflammatory and antioxidant actions in several animal disease models. In the present study, the effects and mechanisms of sesamin on APAP-induced acute liver injury (ALI) were explored. The results showed that pretreatment with sesamin significantly alleviated APAP-induced ALI, as indicated by decreased serum aminotransferase a...
Source: Journal of Immunology Research - September 4, 2023 Category: Allergy & Immunology Authors: Hui Du Shiwen Tong Ge Kuang Xia Gong Ningman Jiang Xian Yang Hao Liu Nana Li Yao Xie Yang Xiang Jiashi Guo Zhenhan Li Yinglin Yuan Shengwang Wu Jingyuan Wan Source Type: research
Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto's Thyroiditis
J Immunol Res. 2023 Aug 25;2023:5221658. doi: 10.1155/2023/5221658. eCollection 2023.ABSTRACTT helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto's thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early pregnancy or in patients with HT. The aim of the study was to measure autoantibodies to inflammatory-, Th1- and Th22-cytokines in seru...
Source: Journal of Immunology Research - September 4, 2023 Category: Allergy & Immunology Authors: Szabina Erd ő-Bonyár Di ána Simon Anna Bajnok Jasper N örenberg T ímea Serény-Litvai Ákos Várnagy K álmán Kovács Eszter Hantosi Emese Mez ősi T ímea Berki Source Type: research
Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NF < em > κ < /em > B Signal in Mice
J Immunol Res. 2023 Aug 24;2023:1116841. doi: 10.1155/2023/1116841. eCollection 2023.ABSTRACTAcetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in severe cases by triggering an inflammatory response and oxidative stress. Sesamin has been reported to possess anti-inflammatory and antioxidant actions in several animal disease models. In the present study, the effects and mechanisms of sesamin on APAP-induced acute liver injury (ALI) were explored. The results showed that pretreatment with sesamin significantly alleviated APAP-induced ALI, as indicated by decreased serum aminotransferase a...
Source: Journal of Immunology Research - September 4, 2023 Category: Allergy & Immunology Authors: Hui Du Shiwen Tong Ge Kuang Xia Gong Ningman Jiang Xian Yang Hao Liu Nana Li Yao Xie Yang Xiang Jiashi Guo Zhenhan Li Yinglin Yuan Shengwang Wu Jingyuan Wan Source Type: research
