KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer
CONCLUSIONS: The local infection or inflammation of ovarian may affect the immunity of OV. KIF26B and CREB3L1 are expected to be potential targets for the immunotherapy of OV.PMID:38380081 | PMC:PMC10878761 | DOI:10.1155/2024/4817924 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Shanshan Cong Yao Fu Xibo Zhao Qiuyan Guo Tian Liang Di Wu Jing Wang Guangmei Zhang Source Type: research
Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach
This study aimed to estimate the seroprevalence of anti-Toxocara immunoglobulin G (IgG) antibodies and the associated risk factors among general populations living in urban and rural areas of Abadan and Khorramshahr cities in Khuzestan Province, Southwest Iran. This cross-sectional study was conducted between March and September 2022. There were 363 participants (190 females and 173 males) aged from <20 to ≥60 years old. Anti-Toxocara IgG antibodies in serum samples were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). A structured questionnaire was employed to collect information reg...
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Masoud Foroutan Aida Vafae Eslahi Shahrzad Soltani Naser Kamyari Ehsan Moradi-Joo Jean-Francois Magnaval Milad Badri Source Type: research
KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer
CONCLUSIONS: The local infection or inflammation of ovarian may affect the immunity of OV. KIF26B and CREB3L1 are expected to be potential targets for the immunotherapy of OV.PMID:38380081 | PMC:PMC10878761 | DOI:10.1155/2024/4817924 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Shanshan Cong Yao Fu Xibo Zhao Qiuyan Guo Tian Liang Di Wu Jing Wang Guangmei Zhang Source Type: research
Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach
This study aimed to estimate the seroprevalence of anti-Toxocara immunoglobulin G (IgG) antibodies and the associated risk factors among general populations living in urban and rural areas of Abadan and Khorramshahr cities in Khuzestan Province, Southwest Iran. This cross-sectional study was conducted between March and September 2022. There were 363 participants (190 females and 173 males) aged from <20 to ≥60 years old. Anti-Toxocara IgG antibodies in serum samples were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). A structured questionnaire was employed to collect information reg...
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Masoud Foroutan Aida Vafae Eslahi Shahrzad Soltani Naser Kamyari Ehsan Moradi-Joo Jean-Francois Magnaval Milad Badri Source Type: research
KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer
CONCLUSIONS: The local infection or inflammation of ovarian may affect the immunity of OV. KIF26B and CREB3L1 are expected to be potential targets for the immunotherapy of OV.PMID:38380081 | PMC:PMC10878761 | DOI:10.1155/2024/4817924 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Shanshan Cong Yao Fu Xibo Zhao Qiuyan Guo Tian Liang Di Wu Jing Wang Guangmei Zhang Source Type: research
Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach
This study aimed to estimate the seroprevalence of anti-Toxocara immunoglobulin G (IgG) antibodies and the associated risk factors among general populations living in urban and rural areas of Abadan and Khorramshahr cities in Khuzestan Province, Southwest Iran. This cross-sectional study was conducted between March and September 2022. There were 363 participants (190 females and 173 males) aged from <20 to ≥60 years old. Anti-Toxocara IgG antibodies in serum samples were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). A structured questionnaire was employed to collect information reg...
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Masoud Foroutan Aida Vafae Eslahi Shahrzad Soltani Naser Kamyari Ehsan Moradi-Joo Jean-Francois Magnaval Milad Badri Source Type: research
KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer
CONCLUSIONS: The local infection or inflammation of ovarian may affect the immunity of OV. KIF26B and CREB3L1 are expected to be potential targets for the immunotherapy of OV.PMID:38380081 | PMC:PMC10878761 | DOI:10.1155/2024/4817924 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Shanshan Cong Yao Fu Xibo Zhao Qiuyan Guo Tian Liang Di Wu Jing Wang Guangmei Zhang Source Type: research
Upper Airway Epithelial Tissue Transcriptome Analysis Reveals Immune Signatures Associated with COVID-19 Severity in Ghanaians
J Immunol Res. 2024 Feb 12;2024:6668017. doi: 10.1155/2024/6668017. eCollection 2024.ABSTRACTThe immunological signatures driving the severity of coronavirus disease 19 (COVID-19) in Ghanaians remain poorly understood. We performed bulk transcriptome sequencing of nasopharyngeal samples from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected Ghanaians with mild and severe COVID-19, as well as healthy controls to characterize immune signatures at the primary SARS-CoV-2 infection site and identify drivers of disease severity. Generally, a heightened antiviral response was observed in SARS-CoV-2-infected Gh...
Source: Journal of Immunology Research - February 20, 2024 Category: Allergy & Immunology Authors: John Demby Sandi Joshua I Levy Kesego Tapela Mark Zeller Joshua Afari Yeboah Daniel Frimpong Saka Donald S Grant Gordon A Awandare Peter K Quashie Kristian G Andersen Lily Paemka Source Type: research
Disturbances in the IgG Antibody Profile in HIV-Exposed Uninfected Infants Associated with Maternal Factors
In this study, plasma from 69 HEU newborns, their mothers, and 71 control pairs was quantified via immunoassays for each IgG isotype. Furthermore, we followed the antibody profile of HEUs throughout the first year of life. We showed that mothers present an antibody profile characterized by high concentrations of IgG1 and IgG3 but reduced IgG2, and HEU infants are born with an IgG subclass profile similar to that of their maternal pair. Interestingly, this passively transferred profile could remain influenced even during their own antibody production in HEU infants, depending on maternal conditions such as CD4+ T-cell count...
Source: Journal of Immunology Research - February 20, 2024 Category: Allergy & Immunology Authors: Rodrigo T Camacho-Pacheco Jessica Hern ández-Pineda Yesenia Brito-P érez Noemi Plazola-Camacho Irma A Coronado-Zarco Gabriela Arreola-Ram írez Mextli Y Bermejo-Haro M Angel Najera-Hern ández Gabriela Gonz ález-Pérez Alma Herrera-Salazar Andrea Olmos Source Type: research
Upper Airway Epithelial Tissue Transcriptome Analysis Reveals Immune Signatures Associated with COVID-19 Severity in Ghanaians
J Immunol Res. 2024 Feb 12;2024:6668017. doi: 10.1155/2024/6668017. eCollection 2024.ABSTRACTThe immunological signatures driving the severity of coronavirus disease 19 (COVID-19) in Ghanaians remain poorly understood. We performed bulk transcriptome sequencing of nasopharyngeal samples from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected Ghanaians with mild and severe COVID-19, as well as healthy controls to characterize immune signatures at the primary SARS-CoV-2 infection site and identify drivers of disease severity. Generally, a heightened antiviral response was observed in SARS-CoV-2-infected Gh...
Source: Journal of Immunology Research - February 20, 2024 Category: Allergy & Immunology Authors: John Demby Sandi Joshua I Levy Kesego Tapela Mark Zeller Joshua Afari Yeboah Daniel Frimpong Saka Donald S Grant Gordon A Awandare Peter K Quashie Kristian G Andersen Lily Paemka Source Type: research
Disturbances in the IgG Antibody Profile in HIV-Exposed Uninfected Infants Associated with Maternal Factors
In this study, plasma from 69 HEU newborns, their mothers, and 71 control pairs was quantified via immunoassays for each IgG isotype. Furthermore, we followed the antibody profile of HEUs throughout the first year of life. We showed that mothers present an antibody profile characterized by high concentrations of IgG1 and IgG3 but reduced IgG2, and HEU infants are born with an IgG subclass profile similar to that of their maternal pair. Interestingly, this passively transferred profile could remain influenced even during their own antibody production in HEU infants, depending on maternal conditions such as CD4+ T-cell count...
Source: Journal of Immunology Research - February 20, 2024 Category: Allergy & Immunology Authors: Rodrigo T Camacho-Pacheco Jessica Hern ández-Pineda Yesenia Brito-P érez Noemi Plazola-Camacho Irma A Coronado-Zarco Gabriela Arreola-Ram írez Mextli Y Bermejo-Haro M Angel Najera-Hern ández Gabriela Gonz ález-Pérez Alma Herrera-Salazar Andrea Olmos Source Type: research
RND3 Potentiates Proinflammatory Activation through NOTCH Signaling in Activated Macrophages
In this study, we have identified RND3, a small GTP-binding protein, as a new element in the complex signaling process that leads to macrophage activation. We show that RND3 expression is transiently induced in macrophages activated through Toll receptors and potentiated by IFN-γ. We also demonstrate that RND3 increases NOTCH signaling in macrophages by favoring NOTCH1 expression and its nuclear activity; however, Rnd3 expression seems to be inhibited by NOTCH signaling, setting up a negative regulatory feedback loop. Moreover, increased RND3 protein levels seem to potentiate NFκB and STAT1 transcriptional activity resul...
Source: Journal of Immunology Research - February 12, 2024 Category: Allergy & Immunology Authors: Mar ía José Romero de Ávila Susana L ópez-López Aar ón García-Blázquez Almudena Ruiz-Garc ía Mar ía Julia González-Gómez Mar ía Luisa Nueda Victoriano Baladr ón Ignacio P érez-Roger Enric Poch Bego ña Ballester-Lurbe Jos é Javier García- Source Type: research
