Dupilumab Efficacy in Patients with Type 2 Asthma with and without Elevated Blood Neutrophils
CONCLUSIONS: Dupilumab treatment significantly reduced annualized severe exacerbation rates and improved lung function in patients with uncontrolled, moderate-to-severe, type 2 asthma, irrespective of baseline blood neutrophil count. This trial is registered with NCT02414854.PMID:37901346 | PMC:PMC10602700 | DOI:10.1155/2023/9943584 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Eugene R Bleecker Reynold A Panettieri Njira L Lugogo Jonathan Corren Nadia Daizadeh Juby A Jacob-Nara Yamo Deniz Paul J Rowe Angela Khodzhayev Xavier Soler Thomas J Ferro Christopher N Hansen Source Type: research

The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study
CONCLUSION: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.PMID:37901347 | PMC:PMC10611543 | DOI:10.1155/2023/5863995 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Bente M Houtman Iris Walraven Elke de Grouw Richard W M van der Maazen Leontien C M Kremer Eline van Dulmen-den Broeder Marry M van den Heuvel-Eibrink Wim J E Tissing Dorine Bresters Helena J H van der Pal Andrica C H de Vries Marloes Louwerens Margriet v Source Type: research

Dupilumab Efficacy in Patients with Type 2 Asthma with and without Elevated Blood Neutrophils
CONCLUSIONS: Dupilumab treatment significantly reduced annualized severe exacerbation rates and improved lung function in patients with uncontrolled, moderate-to-severe, type 2 asthma, irrespective of baseline blood neutrophil count. This trial is registered with NCT02414854.PMID:37901346 | PMC:PMC10602700 | DOI:10.1155/2023/9943584 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Eugene R Bleecker Reynold A Panettieri Njira L Lugogo Jonathan Corren Nadia Daizadeh Juby A Jacob-Nara Yamo Deniz Paul J Rowe Angela Khodzhayev Xavier Soler Thomas J Ferro Christopher N Hansen Source Type: research

The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study
CONCLUSION: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.PMID:37901347 | PMC:PMC10611543 | DOI:10.1155/2023/5863995 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Bente M Houtman Iris Walraven Elke de Grouw Richard W M van der Maazen Leontien C M Kremer Eline van Dulmen-den Broeder Marry M van den Heuvel-Eibrink Wim J E Tissing Dorine Bresters Helena J H van der Pal Andrica C H de Vries Marloes Louwerens Margriet v Source Type: research

Dupilumab Efficacy in Patients with Type 2 Asthma with and without Elevated Blood Neutrophils
CONCLUSIONS: Dupilumab treatment significantly reduced annualized severe exacerbation rates and improved lung function in patients with uncontrolled, moderate-to-severe, type 2 asthma, irrespective of baseline blood neutrophil count. This trial is registered with NCT02414854.PMID:37901346 | PMC:PMC10602700 | DOI:10.1155/2023/9943584 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Eugene R Bleecker Reynold A Panettieri Njira L Lugogo Jonathan Corren Nadia Daizadeh Juby A Jacob-Nara Yamo Deniz Paul J Rowe Angela Khodzhayev Xavier Soler Thomas J Ferro Christopher N Hansen Source Type: research

The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study
CONCLUSION: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.PMID:37901347 | PMC:PMC10611543 | DOI:10.1155/2023/5863995 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Bente M Houtman Iris Walraven Elke de Grouw Richard W M van der Maazen Leontien C M Kremer Eline van Dulmen-den Broeder Marry M van den Heuvel-Eibrink Wim J E Tissing Dorine Bresters Helena J H van der Pal Andrica C H de Vries Marloes Louwerens Margriet v Source Type: research

Dupilumab Efficacy in Patients with Type 2 Asthma with and without Elevated Blood Neutrophils
CONCLUSIONS: Dupilumab treatment significantly reduced annualized severe exacerbation rates and improved lung function in patients with uncontrolled, moderate-to-severe, type 2 asthma, irrespective of baseline blood neutrophil count. This trial is registered with NCT02414854.PMID:37901346 | PMC:PMC10602700 | DOI:10.1155/2023/9943584 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Eugene R Bleecker Reynold A Panettieri Njira L Lugogo Jonathan Corren Nadia Daizadeh Juby A Jacob-Nara Yamo Deniz Paul J Rowe Angela Khodzhayev Xavier Soler Thomas J Ferro Christopher N Hansen Source Type: research

The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study
CONCLUSION: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.PMID:37901347 | PMC:PMC10611543 | DOI:10.1155/2023/5863995 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 30, 2023 Category: Allergy & Immunology Authors: Bente M Houtman Iris Walraven Elke de Grouw Richard W M van der Maazen Leontien C M Kremer Eline van Dulmen-den Broeder Marry M van den Heuvel-Eibrink Wim J E Tissing Dorine Bresters Helena J H van der Pal Andrica C H de Vries Marloes Louwerens Margriet v Source Type: research

Association between Butter, Margarine, and Olive Oil Intake and Asthma Symptoms among School Children: Result from a Large-Scale Cross-Sectional Study
CONCLUSION: We found that margarine and butter intake one or two times a week might have an inverse association with asthma and its symptoms among children. Prospective cohort studies are recommended to confirm these findings.PMID:37886368 | PMC:PMC10599880 | DOI:10.1155/2023/2884630 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 27, 2023 Category: Allergy & Immunology Authors: Arezoo Sadat Emrani Bahareh Sasanfar Zahra Nafei Nasrin Behniafard Amin Salehi-Abargouei Source Type: research

Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells
In this study, the effects of irradiation on SLE-like morbidity manifestations in NZBWF1 mice and on CD180-negative cells were investigated. Whole-body irradiation, excluding the head, attenuated SLE-like morbidity in vivo, as indicated by the prevention of the renal lesion development, inhibition of anti-dsDNA antibody production, reduction of urinary protein levels, and prolongation of the lifespan. Irradiation also reduced the proportion of CD180-negative cells in the spleen. Although other immune cells or molecules may be triggered because of the whole-body irradiation treatment, previous research, and the current resu...
Source: Journal of Immunology Research - October 27, 2023 Category: Allergy & Immunology Authors: Kazuko Fujita Taku Kuwabara Bing Wang Kaoru Tanaka Kei Ito Yuri Akishima-Fukasawa Tetuo Mikami Yoshikiyo Akasaka Toshiharu Ishii Source Type: research

Association between Butter, Margarine, and Olive Oil Intake and Asthma Symptoms among School Children: Result from a Large-Scale Cross-Sectional Study
CONCLUSION: We found that margarine and butter intake one or two times a week might have an inverse association with asthma and its symptoms among children. Prospective cohort studies are recommended to confirm these findings.PMID:37886368 | PMC:PMC10599880 | DOI:10.1155/2023/2884630 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 27, 2023 Category: Allergy & Immunology Authors: Arezoo Sadat Emrani Bahareh Sasanfar Zahra Nafei Nasrin Behniafard Amin Salehi-Abargouei Source Type: research

Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells
In this study, the effects of irradiation on SLE-like morbidity manifestations in NZBWF1 mice and on CD180-negative cells were investigated. Whole-body irradiation, excluding the head, attenuated SLE-like morbidity in vivo, as indicated by the prevention of the renal lesion development, inhibition of anti-dsDNA antibody production, reduction of urinary protein levels, and prolongation of the lifespan. Irradiation also reduced the proportion of CD180-negative cells in the spleen. Although other immune cells or molecules may be triggered because of the whole-body irradiation treatment, previous research, and the current resu...
Source: Journal of Immunology Research - October 27, 2023 Category: Allergy & Immunology Authors: Kazuko Fujita Taku Kuwabara Bing Wang Kaoru Tanaka Kei Ito Yuri Akishima-Fukasawa Tetuo Mikami Yoshikiyo Akasaka Toshiharu Ishii Source Type: research

Association between Butter, Margarine, and Olive Oil Intake and Asthma Symptoms among School Children: Result from a Large-Scale Cross-Sectional Study
CONCLUSION: We found that margarine and butter intake one or two times a week might have an inverse association with asthma and its symptoms among children. Prospective cohort studies are recommended to confirm these findings.PMID:37886368 | PMC:PMC10599880 | DOI:10.1155/2023/2884630 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 27, 2023 Category: Allergy & Immunology Authors: Arezoo Sadat Emrani Bahareh Sasanfar Zahra Nafei Nasrin Behniafard Amin Salehi-Abargouei Source Type: research

Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells
In this study, the effects of irradiation on SLE-like morbidity manifestations in NZBWF1 mice and on CD180-negative cells were investigated. Whole-body irradiation, excluding the head, attenuated SLE-like morbidity in vivo, as indicated by the prevention of the renal lesion development, inhibition of anti-dsDNA antibody production, reduction of urinary protein levels, and prolongation of the lifespan. Irradiation also reduced the proportion of CD180-negative cells in the spleen. Although other immune cells or molecules may be triggered because of the whole-body irradiation treatment, previous research, and the current resu...
Source: Journal of Immunology Research - October 27, 2023 Category: Allergy & Immunology Authors: Kazuko Fujita Taku Kuwabara Bing Wang Kaoru Tanaka Kei Ito Yuri Akishima-Fukasawa Tetuo Mikami Yoshikiyo Akasaka Toshiharu Ishii Source Type: research

Sex-Specific Immune Responses to Seasonal Influenza Vaccination in Diabetic Individuals: Implications for Vaccine Efficacy
This study aims to understand the efficacy of the seasonal vaccine against influenza in diabetic groups and undergoing immune mechanisms in different sexes (females and males). In this study, we are reporting about a switching of the immune response of the infected and vaccinated diabetic females towards stronger Th1/Th17 responses with suppressed humoral immunity. They show increased cDC1, enhanced proinflammatory activities within T cells, CD8T activation, Th17 proliferation, and the majority of IgG2 antibody subtypes with reduced neutralization potential. Males with diabetes exhibit enhanced humoral Th2-immunity than th...
Source: Journal of Immunology Research - October 26, 2023 Category: Allergy & Immunology Authors: Anirban Sengupta Noha Al-Otaibi Jorma Hinkula Source Type: research