CD169 Expression in Lymph Nodes is Associated with Increased Infiltration of CD8 < sup > + < /sup > T Cells in Tumors: A Systematic Review and Meta-Analysis
J Immunol Res. 2024 Jan 12;2024:8873767. doi: 10.1155/2024/8873767. eCollection 2024.ABSTRACTThe density of CD169+ macrophages has been reported to positively correlate with the number of CD8+ T cells, although this remains controversial. To better understand this topic, we conducted a meta-analysis. We searched the PubMed, Medline, and Web of Science databases for studies that were published before May 2022 and performed a meta-analysis of the incidence of low and high CD169 expression in groups based on CD8 expression using the random-effects model. A total of 10 studies were included in the meta-analysis. The incidence ...
Source: Journal of Immunology Research - January 22, 2024 Category: Allergy & Immunology Authors: Yong Wang Xiao-Ting Wu Jing Chen Source Type: research
Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies
In conclusion, AAV patients exhibit a skewing of different neutrophil and monocyte subpopulations that are associated with disease subtypes, disease activity, rituximab treatment, and propensity to relapse. These changes may contribute to the inflammatory process and could potentially be used as biomarkers for relapse prediction.PMID:38213873 | PMC:PMC10781522 | DOI:10.1155/2024/6648265 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - January 12, 2024 Category: Allergy & Immunology Authors: Sofia Smargianaki Evelina Elm ér Sandra Lilliebladh Sophie Ohlsson Åsa Pettersson Thomas Hellmark Åsa Cm Johansson Source Type: research
The Plasticity of Immune Cell Response Complicates Dissecting the Underlying Pathology of Multiple Sclerosis
J Immunol Res. 2024 Jan 4;2024:5383099. doi: 10.1155/2024/5383099. eCollection 2024.ABSTRACTMultiple sclerosis (MS) is a neurodegenerative autoimmune disease characterized by the destruction of the myelin sheath of the neuronal axon in the central nervous system. Many risk factors, including environmental, epigenetic, genetic, and lifestyle factors, are responsible for the development of MS. It has long been thought that only adaptive immune cells, especially autoreactive T cells, are responsible for the pathophysiology; however, recent evidence has indicated that innate immune cells are also highly involved in disease ini...
Source: Journal of Immunology Research - January 12, 2024 Category: Allergy & Immunology Authors: Sujan Kumar Sarkar Annie M L Willson Margaret A Jordan Source Type: research
< em > DJ-1 < /em > : A Potential Biomarker Related to Prognosis, Chemoresistance, and Expression of Microenvironmental Chemokine in HR-Positive Breast Cancer
J Immunol Res. 2023 Dec 13;2023:5041223. doi: 10.1155/2023/5041223. eCollection 2023.ABSTRACTDJ-1 is significantly elevated in various malignancies. However, the clinical significance of DJ-1 in hormone receptor (HR)-positive (HR+) breast cancer remains unclear. We evaluated DJ-1 expression in different databases and validated in vitro assay by RT-PCR and western blot among HR+ breast cancer. The correlations between DJ-1 level and tumor-immune were calculated. Mutational landscape, enriched signaling pathways, and drug sensitivity analyses were also assessed between DJ-1 high and low-expression groups. DJ-1 was upregulate...
Source: Journal of Immunology Research - December 21, 2023 Category: Allergy & Immunology Authors: Yinghong Xie Yuancheng Li Mengzhu Yang Source Type: research
