IL-17: Balancing Protective Immunity and Pathogenesis
J Immunol Res. 2023 Aug 12;2023:3360310. doi: 10.1155/2023/3360310. eCollection 2023.ABSTRACTThe biological role of interleukin 17 (IL-17) has been explored during recent decades and identified as a pivotal player in coordinating innate and adaptive immune responses. Notably, IL-17 functions as a double-edged sword with both destructive and protective immunological roles. While substantial progress has implicated unrestrained IL-17 in a variety of infectious diseases or autoimmune conditions, IL-17 plays an important role in protecting the host against pathogens and maintaining physiological homeostasis. In this review, we...
Source: Journal of Immunology Research - August 21, 2023 Category: Allergy & Immunology Authors: Lu Sun Lufei Wang Bethany B Moore Shaoping Zhang Peng Xiao Ann M Decker Hom-Lay Wang Source Type: research

Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq
CONCLUSIONS: This study describes the landscape of the peripheral blood immune system and cell communication in RA, characterizes the abundance of PBMCs, gene expression profiles, and changes in signaling pathways in RA patients, and identifies several key cell subpopulations (DNT and classic monocytes) and specific genes (SOCS3, CREM, B2M, MTFP1, RSRP1, and YWHAB). Meanwhile, we propose that classic monocytes in peripheral blood may migrate to sites of inflammation in synovial tissue under the chemotaxis of the chemokines CCL3 and CCL3L1, differentiate into macrophages, secrete proinflammatory cytokines, and thus particip...
Source: Journal of Immunology Research - August 21, 2023 Category: Allergy & Immunology Authors: Xinqiang Song Yu Zhang Lijun Zhao Jinke Fan Tao Peng Ying Ma Nailiang Guo Xiaotong Wang Xudong Liu Zhe Liu Lei Wang Source Type: research

IL-17: Balancing Protective Immunity and Pathogenesis
J Immunol Res. 2023 Aug 12;2023:3360310. doi: 10.1155/2023/3360310. eCollection 2023.ABSTRACTThe biological role of interleukin 17 (IL-17) has been explored during recent decades and identified as a pivotal player in coordinating innate and adaptive immune responses. Notably, IL-17 functions as a double-edged sword with both destructive and protective immunological roles. While substantial progress has implicated unrestrained IL-17 in a variety of infectious diseases or autoimmune conditions, IL-17 plays an important role in protecting the host against pathogens and maintaining physiological homeostasis. In this review, we...
Source: Journal of Immunology Research - August 21, 2023 Category: Allergy & Immunology Authors: Lu Sun Lufei Wang Bethany B Moore Shaoping Zhang Peng Xiao Ann M Decker Hom-Lay Wang Source Type: research

Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq
CONCLUSIONS: This study describes the landscape of the peripheral blood immune system and cell communication in RA, characterizes the abundance of PBMCs, gene expression profiles, and changes in signaling pathways in RA patients, and identifies several key cell subpopulations (DNT and classic monocytes) and specific genes (SOCS3, CREM, B2M, MTFP1, RSRP1, and YWHAB). Meanwhile, we propose that classic monocytes in peripheral blood may migrate to sites of inflammation in synovial tissue under the chemotaxis of the chemokines CCL3 and CCL3L1, differentiate into macrophages, secrete proinflammatory cytokines, and thus particip...
Source: Journal of Immunology Research - August 21, 2023 Category: Allergy & Immunology Authors: Xinqiang Song Yu Zhang Lijun Zhao Jinke Fan Tao Peng Ying Ma Nailiang Guo Xiaotong Wang Xudong Liu Zhe Liu Lei Wang Source Type: research

Novel Predictive Scoring System for Intravenous Immunoglobulin Resistance Helps Timely Intervention in Kawasaki Disease: The Chinese Experience
CONCLUSION: This study developed a novel risk-scoring system for predicting resistance to IVIG treatment in KD specific to the Chinese population. Although this new model requires further validation, it may be useful for improving prognostic outcomes and reducing the risk of complications associated with KD.PMID:37592925 | PMC:PMC10432039 | DOI:10.1155/2023/6808323 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 18, 2023 Category: Allergy & Immunology Authors: Yan Wang Shuoyin Huang Panpan Wang Yan Wu Yingying Liu Yuting Pan Jinyuan Dong Zhidan Fan Haiguo Yu Source Type: research

Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?
J Immunol Res. 2023 Aug 4;2023:5584492. doi: 10.1155/2023/5584492. eCollection 2023.ABSTRACTInflammation is a physiological mechanism of the immune response and has an important role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the participation of molecules produced by innate immunity cells in response to a variety of pathogen-associated molecular patterns and damage-associated molecular patterns is observed. However, chronic inflammation is intrinsically associated with leukemogenesis, as it induces DNA damage in hematopoietic stem cells and contributes to the creation of the prele...
Source: Journal of Immunology Research - August 14, 2023 Category: Allergy & Immunology Authors: Fab íola Silva Alves-Hanna Juniel Assis Crespo-Neto Glenda Menezes Nogueira Daniele S á Pereira Amanda Barros Lima Tha ís Lohana Pereira Ribeiro Vit ória Giovanna Rodrigues Santos Joey Ramone Ferreira Fonseca F ábio Magalhães-Gama Aya Sadahiro Allys Source Type: research

Early Life Exposure to Human Milk Oligosaccharides Reduces Allergic Response in a Murine Asthma Model
CONCLUSION: We propose a model in which orally administered HMOs delivered during early life shift the microbiota toward increased production of SCFAs, which dampens the allergic immune responses behind allergy and asthma. Overall, these data suggest the potential for HMO supplementation to protect infants against asthma development later in life, with possible benefits against additional atopic diseases such as eczema and food allergies.PMID:37545544 | PMC:PMC10404156 | DOI:10.1155/2023/9603576 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 7, 2023 Category: Allergy & Immunology Authors: Tahereh Bozorgmehr Rozlyn C T Boutin Sarah E Woodward Katherine Donald Jo May Chow Rachael H Buck B Brett Finlay Source Type: research