Clinical and Genetic Spectrum of Nine Cases of NLRP3-Associated Autoinflammatory Disease (NLRP3-AID) and Identification of One Novel NLRP3 Mutation by Genetic Variation Analyses
CONCLUSIONS: Our study illuminated the distinct clinical and genetic features of Chinese NLRP3-AID patients, emphasizing the significance of early genetic screening. Despite delayed diagnosis, treatment primarily with glucocorticoids and biologic agents, led to favorable outcomes. Genetic heterogeneity, including a novel mutation, highlighted the complexity of NLRP3-AID in this population.PMID:38481988 | PMC:PMC10937081 | DOI:10.1155/2024/5722548 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 14, 2024 Category: Allergy & Immunology Authors: Yaoyao Shangguan Xingru Ding Le Ma Yi-Xin Cai Shulei Xiang Xiu-Feng Huang Yunyan Shen Hai-Guo Yu Wenjie Zheng Source Type: research
The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2-M1 Macrophage Reprogramming
J Immunol Res. 2024 Feb 29;2024:7484490. doi: 10.1155/2024/7484490. eCollection 2024.ABSTRACTMacrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction of macrophages from the peritoneum and TAS in intact healthy mice and those with developed Lewis carcinoma, both untreated and treated a...
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Vera S Ruzanova Svetlana S Kirikovich Evgeniy V Levites Anastasia S Proskurina Evgeniya V Dolgova Genrikh S Ritter Yaroslav R Efremov Tatyana D Dubatolova Alexander V Sysoev Danil I Koleno Alexandr A Ostanin Elena R Chernykh Sergey S Bogachev Source Type: research
Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study
CONCLUSION: Our MR analysis indicated that suggestive associations between circulating levels of FGFBasic, IL-2, and MIF and PD risk. In addition, MIG, bNGF, IL-17, and IFNg are more likely to be involved in the development of downstream PD.PMID:38455364 | PMC:PMC10919978 | DOI:10.1155/2024/9069870 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Hua Xue Qian Luo Jiajia Chen Wenhui Fan Source Type: research
The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2-M1 Macrophage Reprogramming
J Immunol Res. 2024 Feb 29;2024:7484490. doi: 10.1155/2024/7484490. eCollection 2024.ABSTRACTMacrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction of macrophages from the peritoneum and TAS in intact healthy mice and those with developed Lewis carcinoma, both untreated and treated a...
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Vera S Ruzanova Svetlana S Kirikovich Evgeniy V Levites Anastasia S Proskurina Evgeniya V Dolgova Genrikh S Ritter Yaroslav R Efremov Tatyana D Dubatolova Alexander V Sysoev Danil I Koleno Alexandr A Ostanin Elena R Chernykh Sergey S Bogachev Source Type: research
Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study
CONCLUSION: Our MR analysis indicated that suggestive associations between circulating levels of FGFBasic, IL-2, and MIF and PD risk. In addition, MIG, bNGF, IL-17, and IFNg are more likely to be involved in the development of downstream PD.PMID:38455364 | PMC:PMC10919978 | DOI:10.1155/2024/9069870 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Hua Xue Qian Luo Jiajia Chen Wenhui Fan Source Type: research
The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2-M1 Macrophage Reprogramming
J Immunol Res. 2024 Feb 29;2024:7484490. doi: 10.1155/2024/7484490. eCollection 2024.ABSTRACTMacrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction of macrophages from the peritoneum and TAS in intact healthy mice and those with developed Lewis carcinoma, both untreated and treated a...
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Vera S Ruzanova Svetlana S Kirikovich Evgeniy V Levites Anastasia S Proskurina Evgeniya V Dolgova Genrikh S Ritter Yaroslav R Efremov Tatyana D Dubatolova Alexander V Sysoev Danil I Koleno Alexandr A Ostanin Elena R Chernykh Sergey S Bogachev Source Type: research
Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study
CONCLUSION: Our MR analysis indicated that suggestive associations between circulating levels of FGFBasic, IL-2, and MIF and PD risk. In addition, MIG, bNGF, IL-17, and IFNg are more likely to be involved in the development of downstream PD.PMID:38455364 | PMC:PMC10919978 | DOI:10.1155/2024/9069870 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Hua Xue Qian Luo Jiajia Chen Wenhui Fan Source Type: research
The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2-M1 Macrophage Reprogramming
J Immunol Res. 2024 Feb 29;2024:7484490. doi: 10.1155/2024/7484490. eCollection 2024.ABSTRACTMacrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction of macrophages from the peritoneum and TAS in intact healthy mice and those with developed Lewis carcinoma, both untreated and treated a...
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Vera S Ruzanova Svetlana S Kirikovich Evgeniy V Levites Anastasia S Proskurina Evgeniya V Dolgova Genrikh S Ritter Yaroslav R Efremov Tatyana D Dubatolova Alexander V Sysoev Danil I Koleno Alexandr A Ostanin Elena R Chernykh Sergey S Bogachev Source Type: research
Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study
CONCLUSION: Our MR analysis indicated that suggestive associations between circulating levels of FGFBasic, IL-2, and MIF and PD risk. In addition, MIG, bNGF, IL-17, and IFNg are more likely to be involved in the development of downstream PD.PMID:38455364 | PMC:PMC10919978 | DOI:10.1155/2024/9069870 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Hua Xue Qian Luo Jiajia Chen Wenhui Fan Source Type: research
The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2-M1 Macrophage Reprogramming
J Immunol Res. 2024 Feb 29;2024:7484490. doi: 10.1155/2024/7484490. eCollection 2024.ABSTRACTMacrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction of macrophages from the peritoneum and TAS in intact healthy mice and those with developed Lewis carcinoma, both untreated and treated a...
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Vera S Ruzanova Svetlana S Kirikovich Evgeniy V Levites Anastasia S Proskurina Evgeniya V Dolgova Genrikh S Ritter Yaroslav R Efremov Tatyana D Dubatolova Alexander V Sysoev Danil I Koleno Alexandr A Ostanin Elena R Chernykh Sergey S Bogachev Source Type: research
Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study
CONCLUSION: Our MR analysis indicated that suggestive associations between circulating levels of FGFBasic, IL-2, and MIF and PD risk. In addition, MIG, bNGF, IL-17, and IFNg are more likely to be involved in the development of downstream PD.PMID:38455364 | PMC:PMC10919978 | DOI:10.1155/2024/9069870 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 8, 2024 Category: Allergy & Immunology Authors: Hua Xue Qian Luo Jiajia Chen Wenhui Fan Source Type: research
Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes
In this study, we demonstrated that Elo pretreatment significantly enhanced CD16-independent NK cell-mediated cytotoxicity in both SLAMF7-positive MM.1S and SLAMF7-negative K562, U266, and RPMI 8226 tumor cells. Upon direct simulation of CD16-independent NK cells with Elo, increased levels of CD107a degranulation and IFN-γ secretion were observed along with the upregulation of granzyme B, TNF-α, and IL-1α gene expression. The enhanced NK cell function could also be attributed to the increased expression of the transcription factors T-BET and EOMES. Furthermore, the augmentation of the antitumor effects of CD16-independe...
Source: Journal of Immunology Research - March 6, 2024 Category: Allergy & Immunology Authors: Yan-Hua Wang Shotaro Hagiwara Hiroshi Kazama Yuki Iizuka Norina Tanaka Junji Tanaka Source Type: research
Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach
This study aimed to estimate the seroprevalence of anti-Toxocara immunoglobulin G (IgG) antibodies and the associated risk factors among general populations living in urban and rural areas of Abadan and Khorramshahr cities in Khuzestan Province, Southwest Iran. This cross-sectional study was conducted between March and September 2022. There were 363 participants (190 females and 173 males) aged from <20 to ≥60 years old. Anti-Toxocara IgG antibodies in serum samples were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). A structured questionnaire was employed to collect information reg...
Source: Journal of Immunology Research - February 21, 2024 Category: Allergy & Immunology Authors: Masoud Foroutan Aida Vafae Eslahi Shahrzad Soltani Naser Kamyari Ehsan Moradi-Joo Jean-Francois Magnaval Milad Badri Source Type: research
