GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells
J Immunol Res. 2023 Nov 6;2023:5532617. doi: 10.1155/2023/5532617. eCollection 2023.ABSTRACTLung squamous cell carcinoma (LUSC) is associated with poor clinical prognosis and lacks available targeted agents. GPC3 is upregulated in LUSC. Our study aimed to explore the roles of GPC3 in LUSC and the antitumor effects of HLA-A2-restricted GPC3 antigenic peptide-sensitized dendritic cell (DC)-induced cytotoxic T lymphocytes (CTLs) on LUSC. LUSC cells with GPC3 knockdown and overexpression were built using lentivirus packaging, and cell viability, clone formation, apoptosis, cycle, migration, and invasion were determined. Wester...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Jing Ning Jianqiao Ding Shu Wang Youhong Jiang Daqing Wang Shenyi Jiang Source Type: research
Common Pollen Modulate Immune Responses against Viral-Like Challenges in Airway Coculture Model
J Immunol Res. 2023 Nov 6;2023:6639092. doi: 10.1155/2023/6639092. eCollection 2023.ABSTRACTRecent research indicates that exposure to pollen increases the risk and severity of respiratory infections, while studies also suggest that it may possess a protective function. Our aim was to investigate how exposure to common pollen modifies airway cells' responses to viral- or bacterial-like challenges and vice versa. Cocultured A549 and THP-1 cells were exposed to three doses of four different pollens (Alnus glutinosa, Betula pendula, Phleum pratense, or Ambrosia artemisiifolia) and subsequently to Toll-like receptor (TLR) liga...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Tarleena Tossavainen Maria-Viola Martikainen Hanna Loukola Marjut Roponen Source Type: research
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells
J Immunol Res. 2023 Nov 6;2023:5532617. doi: 10.1155/2023/5532617. eCollection 2023.ABSTRACTLung squamous cell carcinoma (LUSC) is associated with poor clinical prognosis and lacks available targeted agents. GPC3 is upregulated in LUSC. Our study aimed to explore the roles of GPC3 in LUSC and the antitumor effects of HLA-A2-restricted GPC3 antigenic peptide-sensitized dendritic cell (DC)-induced cytotoxic T lymphocytes (CTLs) on LUSC. LUSC cells with GPC3 knockdown and overexpression were built using lentivirus packaging, and cell viability, clone formation, apoptosis, cycle, migration, and invasion were determined. Wester...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Jing Ning Jianqiao Ding Shu Wang Youhong Jiang Daqing Wang Shenyi Jiang Source Type: research
Common Pollen Modulate Immune Responses against Viral-Like Challenges in Airway Coculture Model
J Immunol Res. 2023 Nov 6;2023:6639092. doi: 10.1155/2023/6639092. eCollection 2023.ABSTRACTRecent research indicates that exposure to pollen increases the risk and severity of respiratory infections, while studies also suggest that it may possess a protective function. Our aim was to investigate how exposure to common pollen modifies airway cells' responses to viral- or bacterial-like challenges and vice versa. Cocultured A549 and THP-1 cells were exposed to three doses of four different pollens (Alnus glutinosa, Betula pendula, Phleum pratense, or Ambrosia artemisiifolia) and subsequently to Toll-like receptor (TLR) liga...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Tarleena Tossavainen Maria-Viola Martikainen Hanna Loukola Marjut Roponen Source Type: research
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells
J Immunol Res. 2023 Nov 6;2023:5532617. doi: 10.1155/2023/5532617. eCollection 2023.ABSTRACTLung squamous cell carcinoma (LUSC) is associated with poor clinical prognosis and lacks available targeted agents. GPC3 is upregulated in LUSC. Our study aimed to explore the roles of GPC3 in LUSC and the antitumor effects of HLA-A2-restricted GPC3 antigenic peptide-sensitized dendritic cell (DC)-induced cytotoxic T lymphocytes (CTLs) on LUSC. LUSC cells with GPC3 knockdown and overexpression were built using lentivirus packaging, and cell viability, clone formation, apoptosis, cycle, migration, and invasion were determined. Wester...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Jing Ning Jianqiao Ding Shu Wang Youhong Jiang Daqing Wang Shenyi Jiang Source Type: research
Common Pollen Modulate Immune Responses against Viral-Like Challenges in Airway Coculture Model
J Immunol Res. 2023 Nov 6;2023:6639092. doi: 10.1155/2023/6639092. eCollection 2023.ABSTRACTRecent research indicates that exposure to pollen increases the risk and severity of respiratory infections, while studies also suggest that it may possess a protective function. Our aim was to investigate how exposure to common pollen modifies airway cells' responses to viral- or bacterial-like challenges and vice versa. Cocultured A549 and THP-1 cells were exposed to three doses of four different pollens (Alnus glutinosa, Betula pendula, Phleum pratense, or Ambrosia artemisiifolia) and subsequently to Toll-like receptor (TLR) liga...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Tarleena Tossavainen Maria-Viola Martikainen Hanna Loukola Marjut Roponen Source Type: research
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells
J Immunol Res. 2023 Nov 6;2023:5532617. doi: 10.1155/2023/5532617. eCollection 2023.ABSTRACTLung squamous cell carcinoma (LUSC) is associated with poor clinical prognosis and lacks available targeted agents. GPC3 is upregulated in LUSC. Our study aimed to explore the roles of GPC3 in LUSC and the antitumor effects of HLA-A2-restricted GPC3 antigenic peptide-sensitized dendritic cell (DC)-induced cytotoxic T lymphocytes (CTLs) on LUSC. LUSC cells with GPC3 knockdown and overexpression were built using lentivirus packaging, and cell viability, clone formation, apoptosis, cycle, migration, and invasion were determined. Wester...
Source: Journal of Immunology Research - November 15, 2023 Category: Allergy & Immunology Authors: Jing Ning Jianqiao Ding Shu Wang Youhong Jiang Daqing Wang Shenyi Jiang Source Type: research
Understanding How Minerals Contribute to Optimal Immune Function
J Immunol Res. 2023 Nov 1;2023:3355733. doi: 10.1155/2023/3355733. eCollection 2023.ABSTRACTSufficient mineral supply is vital not only for the innate immune system but also for the components of the adaptive immune defense, which encompass defense mechanisms against pathogens and the delicate balance of pro- and anti-inflammatory regulation in the long term. Generally, a well-balanced diet is capable of providing the necessary minerals to support the immune system. Nevertheless, specific vulnerable populations should be cautious about obtaining adequate amounts of minerals such as magnesium, zinc, copper, iron, and seleni...
Source: Journal of Immunology Research - November 10, 2023 Category: Allergy & Immunology Authors: Alina Stefanache Ionut-Iulian Lungu Ioan-Adrian Butnariu Gabriela Calin Cristian Gutu Constantin Marcu Carmen Grierosu Elena Roxana Bogdan Goroftei Letitia-Doina Duceac Marius Gabriel Dabija Florina Popa Daniela Damir Source Type: research
Bone Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Lipopolysaccharide-Induced Lung Injury Via the miR-21-5p/PCSK6 Pathway
J Immunol Res. 2023 Oct 28;2023:3291137. doi: 10.1155/2023/3291137. eCollection 2023.ABSTRACTAcute lung injury (ALI) is a life-threatening disease that currently lacks a cure. Although stem cell-derived small extracellular vesicles (sEVs) have shown promising effects in the treatment of ALI, their underlying mechanisms and responsible components have yet to be identified. Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a gene involved in inflammation and a potential target of miR-21-5p, a microRNA enriched in stem cell-derived sEVs. The current study investigated the role of PCSK6 in lipopolysaccharide (LPS)-induc...
Source: Journal of Immunology Research - November 8, 2023 Category: Allergy & Immunology Authors: Bo Cai Weidong Song Song Chen Jie Sun Rui Zhou Zhen Han Jian Wan Source Type: research
Circulating miR-320b Contributes to CD4+ T-Cell Proliferation in Systemic Lupus Erythematosus via MAP3K1
J Immunol Res. 2023 Oct 26;2023:6696967. doi: 10.1155/2023/6696967. eCollection 2023.ABSTRACTSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies and tissue inflammation. Mesenchymal stem cells (MSCs) have emerged as a promising candidate therapy for SLE owing to the immunomodulatory and regenerative properties. Circulating miRNAs are small, single-stranded noncoding RNAs in a variety of body fluids that regulate numerous immunologic and inflammatory pathways. Recent studies have revealed many differentially expressed circulating miRNAs in autoimmune diseases ...
Source: Journal of Immunology Research - November 6, 2023 Category: Allergy & Immunology Authors: Zutong Li Rou Wang Dandan Wang Shujie Zhang Hua Song Shuai Ding Yantong Zhu Xin Wen Hui Li Hongwei Chen Shanshan Liu Lingyun Sun Source Type: research
