The Expression of Semaphorin3E in Vagal Ganglion and Lung Tissue Is Related to Airway Hyperresponsiveness in Murine Asthma Model
CONCLUSION: Sema3E in lungs and vagal ganglia is related to eosinophilic inflammation and has a protective effect on OVA-induced AHR in asthma.PMID:38111650 | PMC:PMC10727799 | DOI:10.1155/2023/6459234 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 19, 2023 Category: Allergy & Immunology Authors: Liyan Chen Xiaohui Yuan Yaowei He Zichuan Fan Ya Guan Qiuying Li Yaying Chen Lianglan Bao Yidan Huang Kefang Lai Source Type: research
Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases
In this study, we investigate and correlate the differential effects of γc cytokines in NK cell expansion and activation. IL-2 and IL-15 are mainly responsible for NK cell activation, while IL-21 preferentially stimulates NK cell proliferation. Blockade of Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway by either JAK inhibitors or antibodies targeting γc receptor subunits reverses the γc cytokine-induced NK cell activation, leading to suppression of its autoimmunity-like phenotype in vitro. These results underline the mechanisms of how γc cytokines trigger autoimmune ...
Source: Journal of Immunology Research - December 18, 2023 Category: Allergy & Immunology Authors: Wai Chung Wu Carol Shiu Tak Keung Tong Shui On Leung Chin Wai Hui Source Type: research
