Total Neoadjuvant Therapy (TNT) with Full Dose Concurrent Chemotherapy in Locally Advanced Rectal Adenocarcinoma Including Signet Ring and Mucinous Cancers
ConclusionThe hybrid TNT regimen was administered without significant dose delays or interruptions. Toxicity was manageable but with two treatment-related deaths. Ability to undergo surgery after TNT predicted for improved DFS and OS. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 21, 2023 Category: Cancer & Oncology Source Type: research
Impact of Body Mass Index on Postoperative Pain and Opioid Administration After Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
ConclusionBMI is not related to postoperative pain or opioid use, howevermoderate to severe pain and synchronous PC are factors associated with requiring opioids. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 17, 2023 Category: Cancer & Oncology Source Type: research
Role of Circulating Tumor DNA Among Patients with Colorectal Peritoneal Metastases
ConclusionCirculating-tumor DNA is a potentially useful surveillance tool for patients with CRC. However, the sensitivity of ctDNA to detect CRPM is variable and warrants further inquiry. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 12, 2023 Category: Cancer & Oncology Source Type: research
The Role of Small Interfering RNAs in Hepatocellular Carcinoma
ConclusionsThis paper mainly reviews the research on HCC treatment based on siRNA in recent years, and summarizes and classifies the HCC treatment targets and siRNA delivery systems. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 11, 2023 Category: Cancer & Oncology Source Type: research
Modeling Epidemiology Data with Machine Learning Technique to Detect Risk Factors for Gastric Cancer
ConclusionThe results indicate that this model can effectively detect gastric cancer (GC) by utilizing important risk factors, thus avoiding the need for invasive procedures. The model ’s performance is reliable when provided with an adequate amount of input data, and as the dataset expands, its accuracy and generalization improve significantly. Overall, the trained system’s success stems from its ability to identify risk factors and identify cancer patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 10, 2023 Category: Cancer & Oncology Source Type: research
Relationship Between ABO Blood Group and Microsatellite Instability in Colorectal Cancer: A Retrospective Single-Center Study
ConclusionsMSI-H CRC is an important subgroup in colon cancer with different molecular and clinicopathological features. It was observed that O-blood group was 4.2 times more common in MSI-H CRC. We believe that clarifying the relationship between microsatellite instability and O-blood group and its possible genetic and epigenetic mechanisms in larger studies will enable us to better understand tumor behavior and prognosis, also affect our treatment choices of these patient groups. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 7, 2023 Category: Cancer & Oncology Source Type: research
Availability of Primary Care Physicians and Racial Disparities in Colorectal Cancer-Related Mortality in the United States
ConclusionsThese findings suggest that racial disparities in CRC-related mortality may at least in part be related to lower availability of PCPs. Efforts focused on the development of strategies focused on improving access to primary care may help bridge racial disparities in CRC-related outcomes. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 7, 2023 Category: Cancer & Oncology Source Type: research
18F-FDG-PET/CT to Detect Pathological Complete Response After Neoadjuvant Treatment in Patients with Cancer of the Esophagus or Gastroesophageal Junction: Accuracy and Long-Term Implications
ConclusionPatients with a pCR have a higher probability of survival compared to noncomplete responders. One third of patients with a pCR do develop recurrent disease, and pCR can therefore not be equated with cure. FDG-PET/CT was inaccurate to predict pCR and therefore cannot be used as a sole diagnostic tool to predict pCR after CRT for esophageal cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 1, 2023 Category: Cancer & Oncology Source Type: research
Gemcitabine, Cisplatin, and Nab-Paclitaxel as a First-Line Therapy for Advanced Biliary Tract Cancers
ConclusionOur study indicates that GCNP leads to improved response rates, increased chances of resectability, and possibly better survival in patients with GBC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 27, 2023 Category: Cancer & Oncology Source Type: research
Global, Regional, and National Quality of Care Index (QCI) of Gastric Cancer: A Systematic Analysis for the Global Burden of Disease Study 1990-2017
ConclusionThe quality of care of GC has increased worldwide from 1990 to 2017. Also, higher SDI was associated with more quality of care. We recommend conducting more screening and therapeutic programs for early detection and to improve gastric cancer treatment in developing countries. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 26, 2023 Category: Cancer & Oncology Source Type: research
Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC)
ConclusionMSI and frequency ofKRAS andBRAF mutations differed by demographics. Racial/ethnic disparities in OS differed by mutation. Future studies should explore biological and/or social determinants underlying these differences. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 24, 2023 Category: Cancer & Oncology Source Type: research
The Prognostic Role of Mismatch Repair Status and CDX-2 Expression with Inflammatory Markers and Pathological Risk Factors in Stage II and III Colon Cancer: Multicenter Real-Life Data
ConclusionCDX-2 loss was an independent prognostic factor for DFS and disease recurrence in early-stage colon cancer. MSS patients with CDX-2 loss had significantly worse survival outcomes, and this might be the reason for deciding on adjuvant chemotherapy. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 22, 2023 Category: Cancer & Oncology Source Type: research
Value of Endoscopic Ultrasound-Guided Through-the-Needle Biopsy in Pancreatic Cystic Lesions. A Systematic Review and Meta-Analysis
ConclusionsEUS-TTNB has good sensitivity with excellent specificity in accurately classifying PCLs as neoplastic or non-neoplastic. Adding EUS-TTNB to EUS-FNA increases the accuracy of EUS-guided approach in diagnosing PCLs. However, it could significantly increase the risk of post-procedural pancreatitis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 21, 2023 Category: Cancer & Oncology Source Type: research
Perioperative Blood Transfusions and Anastomotic Leak After Colorectal Surgery for Cancer in an Australian Hospital
ConclusionPerioperative blood transfusions are associated with a significantly increased risk of an anastomotic leak following bowel resection with primary anastomosis for colorectal cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 19, 2023 Category: Cancer & Oncology Source Type: research
Interventions to Improve Surveillance for Hepatocellular Carcinoma in High-Risk Patients: A Scoping Review
ConclusionDespite improvements in HCC surveillance rates with intervention, compliance remained suboptimal. Further analysis of which interventions yield the greatest increases in HCC surveillance, design of multi-pronged strategies, and improved implementation are needed. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 16, 2023 Category: Cancer & Oncology Source Type: research
