Current Progress and Advances in Gastrointestinal Cancers: Highlights from the 2022 Annual American Society of Clinical Oncology (ASCO) Gastrointestinal Meeting
ConclusionThis year ’s hybrid ASCO-GI symposium (2022) introduced many promising new treatment strategies in GI oncology, with several changes in clinical practice for patients with advanced hepatocellular carcinoma (HCC), cholangiocarcinoma, and metastatic colorectal cancer (CRC). (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 19, 2022 Category: Cancer & Oncology Source Type: research
Comparison of Efficacy of Aspirin Plus EOX vs. EOX Alone in Patients with Locally Advanced and Metastatic Gastric Cancer: a Randomized Clinical Trial
ConclusionsThere was no improvement in the response rates, progression-free survival, and overall survival on adding aspirin to EOX chemotherapy in locally advanced and metastatic gastric cancer in an unselected population. A further role of PI3K mutation as a biomarker needs to be evaluated in this setting. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 16, 2022 Category: Cancer & Oncology Source Type: research
HCC in the Middle East
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 8, 2022 Category: Cancer & Oncology Source Type: research
Oncological Outcomes After Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in the Treatment of Peritoneal Carcinomatosis
ConclusionThe OS was in line with the literature. PIPAC could delay oncological progression and improve survival. These encouraging results justify the ongoing and future evaluations of PIPAC by prospective randomized trials. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 1, 2022 Category: Cancer & Oncology Source Type: research
Using Telemedicine to Facilitate Patient Communication and Treatment Decision-Making Following Multidisciplinary Tumor Board Review for Patients with Hepatocellular Carcinoma
ConclusionsUsing telemedicine to communicate treatment recommendations following MTB review was found to be feasible and an acceptable alternative to an in-person visit for patient with HCC. Future studies could include expanding this approach for communicating MTB recommendations to patients with other types of cancers. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 30, 2022 Category: Cancer & Oncology Source Type: research
Adherence to Multidisciplinary Tumor Board Recommendations in Patients With Curable Esophageal and Gastric Cancers
ConclusionsNon-adherence to MDT recommendations was associated with advanced age and tumor stage, and potentially contributes to the worse oncological outcomes in a group of patients already predisposed to poor outcomes. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 27, 2022 Category: Cancer & Oncology Source Type: research
Inclusion of Perineural Invasion with AJCC-TNM Staging: Outcomes from a South Asian Cohort of Curatively Treated Gastric Cancer Patients
ConclusionThe incidence of PNI in gastric cancer is high. The inclusion of PNI with AJCC-TNM staging may better stratify prognostic staging in curatively treated gastric cancer patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 24, 2022 Category: Cancer & Oncology Source Type: research
Regular Aspirin Use Is Associated with a Reduced Risk of Hepatocellular Carcinoma (HCC) in Chronic Liver Disease: a Systematic Review and Meta-analysis
ConclusionRegular aspirin use in chronic liver disease is associated with reduced incidence of HCC without increasing the risk of major GI bleeding. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 18, 2022 Category: Cancer & Oncology Source Type: research
Pre- and Postoperative Levels of Carcinoembryonic Antigen in Microsatellite Stable Versus Instable Colon Cancer: a Retrospective Analysis
ConclusionDespite the better prognosis, MSI tumors are associated with increases in CEA. Our findings shed light on discrepancies related to the prognostic evaluation of MSI tumors. Furthermore, in follow-up of colorectal cancers, CEA measurements should be interpreted differently for MSI and MSS tumors. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 18, 2022 Category: Cancer & Oncology Source Type: research
Evaluation of UGT1A1 and CYP3A Genotyping and Single-Point Irinotecan and Metabolite Concentrations as Predictors of the Occurrence of Adverse Events in Cancer Treatment
ConclusionOur data confirmed the relevance of the pre-emptive genotypic information ofUGT1A1. The [SN-38]/IRI ratio, measured 15 min after the end of the IRI infusion, was a strong predictor of severe toxicity and could be applied to minimize the burden of patients after IRI administration. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 16, 2022 Category: Cancer & Oncology Source Type: research
Oxaliplatin-Induced Sinusoidal Obstruction Syndrome Masquerading as Colorectal Liver Metastasis: A Case Report
ConclusionIn patients with colo-rectal cancer having received oxaliplatin-based chemotherapy, SOS may be considered as one of the causes of newly developed liver lesions, and should be subjected to additional radio-pathologic evaluation to prevent overtreatment and avoiding potentially morbid surgeries. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 6, 2022 Category: Cancer & Oncology Source Type: research
Prognostic Factors in Resected Pancreatic Ductal Adenocarcinoma: Is Neutrophil-Lymphocyte Ratio a Useful Marker?
ConclusionNeutrophil –lymphocyte ratio and delta NLR were not associated with the overall survival in this cohort. Risk factors such as perineural invasion, surgical margins, CA19-9 level, and tumor size showed worse survival in this study, whereas completing adjuvant treatment was a protective factor. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 2, 2022 Category: Cancer & Oncology Source Type: research
Thoracoscopy-Assisted Esophagectomy vs Transhiatal Esophagectomy for Carcinoma Esophagus: a Prospective Comparison of Short-Term Outcomes
ConclusionsTAE achieved higher R0 resection rate and better short-term morbidity than THE. Enrollment of small number of cases in the study precluded statistical significance.Trial RegistrationThis study was registered in Clinical Trial Registry-India (CTRI registration no: CTRI/2018/05/013880) in 14-05-2018. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 1, 2022 Category: Cancer & Oncology Source Type: research
ZAK Gene Expression in Patients with Helicobacter pylori Infection
ConclusionZAK gene expression was higher in GAECs of gastritis cancer than in gastric adenocarcinoma, indicating the protective effect of ZAK against gastric cancer (p < .005). ReducingZAK gene expression shows the negative correlations withH. pylori infection and gastric adenocarcinoma. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 1, 2022 Category: Cancer & Oncology Source Type: research
Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial
ConclusionThe use of topical formulation ofAloe vera 3% diminishes the severity of ARP in colorectal cancer patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 1, 2022 Category: Cancer & Oncology Source Type: research
