Management of Microsatellite Instability High (MSI-H) Gastroesophageal Adenocarcinoma
AbstractBackgroundGastroesophageal cancer is a major cause of cancer-related mortality worldwide. Treatment of both early stage and advanced disease remains highly reliant on cytotoxic chemotherapy. About 4 –24% of gastroesophageal cancers are microsatellite instability high (MSI-H). The MSI-H subtype is associated with favorable prognosis, resistance to cytotoxic chemotherapy, and sensitivity to immune checkpoint inhibitors (ICI). Recent studies have demonstrated promising activity of ICIs in the MS I-H subtype, resulting in fundamental changes in the management of MSI-H gastroesophageal adenocarcinoma.PurposeIn this re...
Source: Journal of Gastrointestinal Cancer - December 22, 2023 Category: Cancer & Oncology Source Type: research

Immunotherapy in Esophagogastric Cancer: Treatment Landscape, Challenges, and New Directions
ConclusionWith further exploration into targeted therapy and immunotherapy, we anticipate the emergence of novel treatments that will improve survival and quality of life in patients with esophagogastric cancers. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 21, 2023 Category: Cancer & Oncology Source Type: research

Efficacy of Atezolizumab Plus Bevacizumab Versus Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma: a Meta-analysis
ConclusionOur study concluded that combination therapy with atezolizumab plus bevacizumab could increase the survival duration without affecting the disease course. Moreover, while the severity of adverse events was greater in the A  + B group, their frequency was comparable to the lenvatinib group. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 14, 2023 Category: Cancer & Oncology Source Type: research

Evolving Trends in Hepatocellular Carcinoma in a Multi-Cultural Australian Tertiary Centre
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 8, 2023 Category: Cancer & Oncology Source Type: research

Clinical and Pathologic Predictors of Tumor Deposits in Colorectal Cancer
ConclusionLymph node invasion, T stage, and MSS were independent risk factors for TDs. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 5, 2023 Category: Cancer & Oncology Source Type: research

Survival Benefit of Induction Chemotherapy with Paclitaxel and Carboplatin Followed by Chemoradiation Versus Postoperative Treatment in Locally Advanced Gastric Cancer: A Retrospective Cohort Study
ConclusionsPatients receiving induction chemotherapy with paclitaxel and carboplatin followed by chemoradiation demonstrated enhanced disease control and survival compared to standard adjuvant regimens. In addition, patients treated with the applied preoperative regimen in this study showed higher pathologic response and overall survival rates than in previous studies. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 27, 2023 Category: Cancer & Oncology Source Type: research

A Successful Central Gastrectomy and Gastro-Gastric Anastomosis for a Large Gastric GIST
ConclusionCentral gastrectomy is an effective method of partial gastrectomy that can be considered in GIST resection; however, more studies are needed to evaluate the efficiency of central gastrectomy in terms of long-term follow-up and terms of R0 respectability in gastric cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 27, 2023 Category: Cancer & Oncology Source Type: research

Prognostic Signature Constructed of Seven Ferroptosis-Related lncRNAs Predicts the Prognosis of HBV-Related HCC
ConclusionA 7-lncRNA signature was identified as a potential prognostic predictor for HBV-HCC patients. Immune therapy may be a promising strategy for HCC patients, especially HBV-HCC patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 25, 2023 Category: Cancer & Oncology Source Type: research

Is Metformin Associated with a Lower Prevalence of Polyps, Adenomas, and Colorectal Carcinoma in Patients with Diabetes Mellitus?
ConclusionIn our study, metformin was associated with less colorectal polyps in diabetic patients compared to other treatment modalities. We observed a nonsignificant trend towards lower polyp detection rates in the metformin group both in unadjusted and adjusted analyses. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 21, 2023 Category: Cancer & Oncology Source Type: research

Acute Appendicitis Caused by Metastasis from Other Organs: A Systematic Review
ConclusionAcute appendicitis secondary to metastatic disease is uncommon but rarely will be the presenting sign of new cancer diagnosis. Most of the patients have other sites of secondary lesions. Surgical treatment is commonly performed to treat appendicitis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 17, 2023 Category: Cancer & Oncology Source Type: research

Prognosis of Elderly Patients with Gastric Cancer Treated with the Best Supportive Care
ConclusionThis result will help clarify the natural history of elderly patients with gastric cancer and provide useful information when choosing treatments in the future. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 17, 2023 Category: Cancer & Oncology Source Type: research

Predicting Peritoneal Carcinomatosis in Locally Advanced Gastric Cancer: The Significance of Tumor Markers in the Peritoneal Washing
ConclusionPerforming the peritoneal liquid harvest during staging laparoscopy makes this analysis cost effective, reproducible, and does not add further morbidity. CA 125 and CEA, individually and in association, are good predictors of progression of disease and mortality within a year of staging laparoscopy in GC patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 15, 2023 Category: Cancer & Oncology Source Type: research

Prognostic Effect of Performance Status on Outcomes of Patients with Colorectal Cancer Receiving First-Line Chemotherapy: A Meta-analysis
ConclusionsPS is a reliable prognostic factor for patients with mCRC receiving first-line chemotherapy but is poorly evaluated in phase III trials. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 15, 2023 Category: Cancer & Oncology Source Type: research

The Impact of Traction Methods on Endoscopic Submucosal Dissection Efficacy for Gastric Neoplasia: A Systematic Review and Meta-analysis
ConclusionsThis study demonstrates the potential benefits of TA-ESD over C-ESD in treating patients with early-stage gastric tumors, highlighting its safety and efficacy. The findings indicate a significant reduction in procedure times at challenging stomach sites with TA-ESD in comparison to C-ESD. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 13, 2023 Category: Cancer & Oncology Source Type: research

Non-endoscopic Screening for Esophageal Squamous Cell Carcinoma: Recent Advances
ConclusionsNon-endoscopic screening is better than endoscopic screening. And the application of tumor biomarkers is much  better than other non-endoscopic screening methods. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - November 4, 2023 Category: Cancer & Oncology Source Type: research