Interaortocaval Lymph Node Metastasis in Gall Bladder Cancer: Is It Regional Node or Metastatic Disease?
ConclusionSelected cases of GBC with IACLN metastases can achieve meaningful survival after curative resection and adjuvant therapy. Survival was inferior to RLN-positive cases but it was higher than the patients who received only palliative chemotherapy. This concept needs further evaluation in a prospective study with larger number of patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 2, 2023 Category: Cancer & Oncology Source Type: research
Effect of Time to Minimally Invasive Esophagectomy After Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma
ConclusionWe suggest the optimal TTS after NAC is 6 –8 weeks. However, this finding must be confirmed by prospective trials. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 1, 2023 Category: Cancer & Oncology Source Type: research
A Review of Circulating Tumor DNA as a Biomarker Guide for Total Neoadjuvant Therapy in Patients with Locally Advanced Rectal Cancer
ConclusionsSubstantial work is still needed before cfDNA/ctDNA monitoring can be widely adopted in the clinical setting. Studies reviewed herein highlight several areas of opportunity for improving the effectiveness and utility of cfDNA/ctDNA for managing patients with LARC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 31, 2023 Category: Cancer & Oncology Source Type: research
Definitive Chemoradiation for Colon Cancer: a Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 30, 2023 Category: Cancer & Oncology Source Type: research
Clinical Significance of Overexpression of Oct4 in Advanced Stage Gallbladder Carcinoma
ConclusionIn conclusion, our data suggests that higher expression of Oct4 may serve as potential biological indicator for tumor aggressiveness and poor prognosis of GBC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 27, 2023 Category: Cancer & Oncology Source Type: research
The Role of Percutaneous Tibial Nerve Stimulation (PTNS) in Low Anterior Resection Syndrome (LARS): A Systematic Review and Meta-analysis
ConclusionsThe application of PTNS in patients with LARS results in an improvement in multiple clinical parameters, including defecation functionality and quality of life. Due to several study limitations, further high quality RCTs are required to delineate the exact efficacy of PTNS. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 27, 2023 Category: Cancer & Oncology Source Type: research
Oligometastatic Colorectal Cancer: A Review of Definitions and Patient Selection for Local Therapies
ConclusionMultidisciplinary management is critical for patients with metastatic CRC due to the complexity of their cases and the nuanced patient, tumor, biological, and anatomical factors that must be weighed when considering local therapy. High-quality prospective randomized data in CRC are needed to further clarify the role of local ablative therapy in patients with unresectable oligometastatic CRC with ongoing studies including the RESOLUTE trial (ACTRN12621001198819) and the upcoming NCTN ERASur trial (NCT05673148). (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 18, 2023 Category: Cancer & Oncology Source Type: research
Correlation of Preoperative Anemia Subtypes with Tumor Characteristics, Systemic Inflammation and Immediate Postoperative Outcomes in Gastrointestinal Cancer Patients — A Prospective Observational Study
ConclusionHigher prevalence of normocytic anemia is observed among patients with gastrointestinal cancer. Normocytic anemia is significantly associated with systemic inflammation with no significant difference in tumor characters and immediate postoperative outcomes. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 12, 2023 Category: Cancer & Oncology Source Type: research
The Role of Probiotics in Colorectal Cancer: A Review
ConclusionsProbiotics have properties that make them useful in the management and prevention of colorectal cancer and can provide new avenue to reduce the occurrence of this malignancy and enhance the patients' quality of life. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 9, 2023 Category: Cancer & Oncology Source Type: research
A Cost-effectiveness Analysis of Adding Cetuximab to the First-line Treatment of Metastatic Colorectal Carcinoma in Iran; Considering Genetic Screening for Precision Medicine
ConclusionAlthough genetic screening in precision medicine reduces costs per outcome, according to the willingness-to-pay threshold of $4349.50 in the Iranian health system, add-on cetuximab to the FOLFIRI regimen is not a cost-effective strategy even with genetic screening and a 20% price reduction. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 9, 2023 Category: Cancer & Oncology Source Type: research
Multi-Disciplinary Management in Rectal Cancer Survivorship: A Clinical Practice Review
AbstractColorectal cancer (CRC) is the third most common cancer in the USA and worldwide. In the USA, nearly one-third of CRC cases are anatomically classified as rectal cancer. Over the past few decades, continued refinement of multimodality treatment and the introduction of new therapeutic agents have enhanced curative treatment rates and quality of life outcomes. As treatments improve and the incidence of young onset rectal cancer rises, the number of rectal cancer survivors grows each year. This trend highlights the growing importance of rectal cancer survivorship. Multimodality therapy with systemic chemotherapy, chem...
Source: Journal of Gastrointestinal Cancer - January 9, 2023 Category: Cancer & Oncology Source Type: research
Variations in the Type of Adjuvant Chemotherapy Among Stage III Colon Cancer Patients in England
ConclusionThere is variation in the type of chemotherapy received for stage III colon cancer patients by sociodemographic factors, despite clear clinical guidelines. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 5, 2023 Category: Cancer & Oncology Source Type: research
The Association of Oral Microbiome Dysbiosis with Gastrointestinal Cancers and Its Diagnostic Efficacy
ConclusionThe results of this study may help future research to select bacteria as an early diagnostic or prognostic biomarker of gastrointestinal cancer. Given the current state of our knowledge, additional research is required to comprehend the multiplex processes underlying the role of bacterial microbiota upon cancer progression and to characterize the complex microbiota-host interaction network. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 5, 2023 Category: Cancer & Oncology Source Type: research
Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases
ConclusionOur finds corroborate existing recommendation for the invasive treatment of PM from CRC in selected patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 3, 2023 Category: Cancer & Oncology Source Type: research
To β or Not to β: Lack of Correlation Between APC Mutation and β-Catenin Nuclear Localization in Colorectal Cancer
ConclusionOur results provide evidence directly from tumor samples for possible non-canonical role(s) for mutantAPC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 31, 2022 Category: Cancer & Oncology Source Type: research
