Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer
ConclusionsThis study may establish a new gastric cancer prognostic indicator based on the biological clock gene and develop new drugs for the treatment of gastric cancer using biological clock gene targets. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 1, 2024 Category: Cancer & Oncology Source Type: research
The Prognostic Importance of Ki-67 in Gastrointestinal Carcinomas: A Meta-analysis and Multi-omics Approach
ConclusionThis study supports that Ki-67 can serve as an independent prognostic biomarker for pancreatic and hepatocellular malignancies in clinical settings. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 27, 2024 Category: Cancer & Oncology Source Type: research
Role of the Microbiome in the Diagnosis and Management of Gastroesophageal Cancers
ConclusionsNowadays, it is widely accepted that changes in the normal gut microbiome causing dysbiosis and immune dysregulation play a role gastroesophageal cancer. Different interventions, including probiotics and prebiotics intake are being developed to improve therapeutic outcomes and mitigate toxicities associated with anticancer treatment. Further studies are required in order to introduce the microbiome among the available tools of precision medicine in the field of anticancer treatment. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 27, 2024 Category: Cancer & Oncology Source Type: research
Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study
ConclusionSarcopenia is associated with the PNI. Sarcopenia and the PNI are independent prognostic factors among patients with resected BTC. Sarcopenia may have better prognostic value when combined with the PNI. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 26, 2024 Category: Cancer & Oncology Source Type: research
Characteristics and Outcomes of Patients with Cystic Fibrosis and Pancreatic Cancer: A Large Database Analysis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 21, 2024 Category: Cancer & Oncology Source Type: research
Short-Term Safety Evaluation of Albumin-Bound Paclitaxel in Intraoperative and Postoperative Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer
ConclusionAlbumin-bound paclitaxel demonstrates good safety and tolerability in HIPEC during and after GC surgery, without increasing the risk of intraoperative complications. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 17, 2024 Category: Cancer & Oncology Source Type: research
Predictive Value of Tumor-Infiltrating Lymphocytes and Ki-67 for Pathological Response to Total Neoadjuvant Therapy in Rectal Cancer
ConclusionThere was a statistically significant correlation between Ki-67, TIL, and pCR following TNT protocol, which may help maximize the therapeutic outcome. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 15, 2024 Category: Cancer & Oncology Source Type: research
Role of Preoperative Radiation Therapy for Resectable Gastric Cancer
ConclusionResults from ongoing and future randomized controlled trials are expected to help define the role of preoperative CRT compared to perioperative chemotherapy alone as well as postoperative CRT for gastric and GEJ cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 14, 2024 Category: Cancer & Oncology Source Type: research
Patient Perceptions of Care Coordination during Neoadjuvant Therapy for Gastrointestinal Cancers: A Mixed Methods Analysis
ConclusionsSuccessful completion of NT requires significant care coordination between patients and healthcare professionals. Yet, in this cross-sectional analysis of patients on a prospective cohort study, patient perceptions of CCC during NT were overall positive. Future research should focus on optimizing other aspects of care delivery in order to improve outcomes of NT. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 14, 2024 Category: Cancer & Oncology Source Type: research
Patterns of Failure Following Preoperative Chemotherapy and Stereotactic Body Radiation Therapy and Resection for Patients with Borderline Resectable or Locally Advanced Pancreatic Cancer
ConclusionsFollowing preoperative chemotherapy and SBRT, locoregional failure outside of the target volume occurred in 3 of 5 recurrences; ENI was associated with improved LRC and LRRFS. Further studies are necessary to define the optimal techniques for preoperative radiation therapy. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 13, 2024 Category: Cancer & Oncology Source Type: research
Clinical Effect of Tumor-Specific Total Nutrients in Patients with Adjuvant Chemotherapy After Radical Gastric Cancer Resection: A Randomized Controlled Trial
ConclusionCombined tumor-specific total nutrient and adjuvant chemotherapy application after radical gastric cancer surgery effectively improves the nutritional state and immune function of the patients and could be applied in clinical practice. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 11, 2024 Category: Cancer & Oncology Source Type: research
Primary Pancreatic GIST — A-Single Centre Case Series and Systematic Review of Literature
ConclusionPancreatic GIST is a rare entity. Due to limited evidence and evolving literature, results cannot be generalised to a larger population. Larger case series with longer follow-up data are required to further understand the disease biology and long-term outcomes of pancreatic GIST. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 7, 2024 Category: Cancer & Oncology Source Type: research
Real Life Data and Outcome of FOLFIRINOX Use in Metastatic Pancreatic Cancer Patients in General Hospitals in the Netherlands
ConclusionSurvival rates for patient with metastatic pancreatic cancer treated with FOLFIRINOX were worse in our study population than in comparative studies. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 6, 2024 Category: Cancer & Oncology Source Type: research
Efficacy of Cisplatin-Containing Chemotherapy Regimens in Patients of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis
ConclusionCisplatin-containing regimens have shown moderate efficacy with significant improvement in overall survival at 1 year, stable disease rate, and progressive disease rate; however, only a small percentage of patients achieved an overall response rate. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 5, 2024 Category: Cancer & Oncology Source Type: research
Effect of Preoperative Body Mass Index on Postoperative and Long-Term Outcomes in an East Indian Gastric Cancer Cohort
ConclusionsIn Eastern Indian gastric cancer patients undergoing curative resection, preoperative higher BMI (overweight/obese) was associated with better long-term survival. Understanding these findings could guide tailored interventions to improve outcomes in this population. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 5, 2024 Category: Cancer & Oncology Source Type: research
