Data Centric Molecular Analysis and Evaluation of Hepatocellular Carcinoma Therapeutics Using Machine Intelligence-Based Tools
ConclusionsWe expect that these series of data-driven analyses can be used as a roadmap to propose early-stage potential inhibitors (from database-scale sets of compounds) to both HCC and other complex diseases, which may subsequently be analyzed with more targeted in silico and experimental approaches. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 15, 2021 Category: Cancer & Oncology Source Type: research
Programmed Cell Death 1 and Hepatocellular Carcinoma: An Epochal Story
AbstractIn recent years, immune-based therapies have emerged as novel pillars for hepatocellular carcinoma (HCC). The rationale of immune-checkpoint inhibitors (ICIs) trial in HCC originated from the fact that the tumor cells and the infiltrating stromal and immune cells promote an immunosuppressive tumor microenvironment, including the up-regulation of immune checkpoint molecules on their surface. Antibody-based blockage targeting inhibitory checkpoint molecules on cytotoxic T cells, including programmed cell death-1 (PD-1) or its counterpart on antigen-presenting cells has shown strong anti-tumor activity in a subset of ...
Source: Journal of Gastrointestinal Cancer - December 11, 2021 Category: Cancer & Oncology Source Type: research
Quality Indicators and Outcomes in a Prospective Cohort of Colorectal Cancer Patients
ConclusionsAfter adjustment for sociodemographic factors, comorbidities, and severity of the disease, performing certain quality indicators of proper health care in patients with colorectal cancer was related to less mortality but higher adverse outcomes.Trial RegistrationClinicalTrials.gov Identifier: NCT02488161. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 10, 2021 Category: Cancer & Oncology Source Type: research
Prognostic Factors of Liver Transplantation for HCC: Comparative Literature Review
ConclusionDetailed preoperative examination, appropriate patient selection, and timing of surgery are seen the most important issues in liver transplant ’s patients with hepatocellular carcinoma. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 9, 2021 Category: Cancer & Oncology Source Type: research
Clinical and Basic Research on Hepatocellular Carcinoma in Turkey
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - December 9, 2021 Category: Cancer & Oncology Source Type: research
