Mixed culture biocatalytic production of the high-value biochemical 7-methylxanthine
7-Methylxanthine, a derivative of caffeine noted for its lack of toxicity and ability to treat and even prevent myopia progression, is a high-value biochemical with limited natural availability. Attempts to pr... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - January 10, 2023 Category: Biotechnology Authors: Meredith B. Mock and Ryan M. Summers Tags: Research Source Type: research
Investigation of two metabolic engineering approaches for (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis
Flux Balance Analysis (FBA) is a well-known bioinformatics tool for metabolic engineering design. Previously, we have successfully used single-level FBA to design metabolic fluxes in Bacillus subtilis to enhance ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - January 10, 2023 Category: Biotechnology Authors: Nunthaphan Vikromvarasiri, Shuhei Noda, Tomokazu Shirai and Akihiko Kondo Tags: Research Source Type: research
Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model
The poor performance of conventional techniques used in cardiovascular disease patients requiring hemodialysis or arterial bypass grafting has prompted tissue engineers to search for clinically appropriate off... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - January 3, 2023 Category: Biotechnology Authors: Francis O. Obiweluozor, Mukhammad Kayumov, Yujin Kwak, Hwa-Jin Cho, Chan-Hee Park, Jun-kyu Park, Yun-Jin Jeong, Dong-Weon Lee, Do-Wan Kim and In-Seok Jeong Tags: Research Source Type: research
High throughput mutagenesis and screening for yeast engineering
The eukaryotic yeast Saccharomyces cerevisiae is a model host utilized for whole cell biocatalytic conversions, protein evolution, and scientific inquiries into the pathogenesis of human disease. Over the past de... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - December 27, 2022 Category: Biotechnology Authors: Kendreze Holland and John Blazeck Tags: Review Source Type: research
Fabricating a robust POSS-PCL nanofiber scaffold for nesting of mesenchymal stem cells: potential application in bone tissue regeneration
According to recent studies, electrospun Poly ( Ɛ-caprolactone) (PCL) is an absorbing candidate for the formulation of biocompatible scaffolds used in tissue engineering. Tissue engineering is a set of techniqu... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - December 21, 2022 Category: Biotechnology Authors: Leyla bagheri, Hasan Valizadeh, Kazem Dindar-safa and Nosratollah Zarghami Tags: Research Source Type: research
Gentamicin-loaded chitosan/folic acid-based carbon quantum dots nanocomposite hydrogel films as potential antimicrobial wound dressing
To provide effective healing in the wound, various carbohydrate polymers are commonly utilized that are highly potent platforms as wound dressing films. In this work, novel antibacterial flexible polymeric hyd... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - December 21, 2022 Category: Biotechnology Authors: Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Pourya Gholizadeh, Parinaz Nezhad-Mokhtari, Khudaverdi Ganbarov, Asghar Tanomand and Hossein Samadi Kafil Tags: Research Source Type: research
Desferrioxamine alleviates UHMWPE particle-induced osteoclastic osteolysis by inhibiting caspase-1-dependent pyroptosis in osteocytes
Cell death and inflammation are the two important triggers of wear particle-induced osteolysis. Particles, including cobalt-chromium-molybdenum and tricalcium phosphate, have been reported to induce pyroptosis... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - December 8, 2022 Category: Biotechnology Authors: Shenli Zhao, Chen Ge, Yao Li, Leilei Chang, Zhou Dan, Yihui Tu, Lianfu Deng, Hui Kang and Changwei Li Tags: Research Source Type: research
Microfluidic chip and isothermal amplification technologies for the detection of pathogenic nucleic acid
The frequency of outbreaks of newly emerging infectious diseases has increased in recent years. The coronavirus disease 2019 (COVID-19) outbreak in late 2019 has caused a global pandemic, seriously endangering... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - December 1, 2022 Category: Biotechnology Authors: Dongli Gao, Xudong Guo, Yi Yang, Hua Shi, Rongzhang Hao, Shengqi Wang, Zhen Jun Li, Rongtao Zhao and Hongbin Song Tags: Review Source Type: research
Applications of carbon dots and its modified carbon dots in bone defect repair
Bone defect repair is a continual and complicated process driven by a variety of variables. Because of its bright multicolor luminescence, superior biocompatibility, water dispersibility, and simplicity of syn... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - November 22, 2022 Category: Biotechnology Authors: Longchuan Zhu, Weijian Kong, Jijun Ma, Renfeng Zhang, Cheng Qin, Hao Liu and Su Pan Tags: Review Source Type: research
Development of a novel defined minimal medium for Gluconobacter oxydans 621H by systematic investigation of metabolic demands
Historically, complex media are used for the cultivation of Gluconobacter oxydans in industry and research. Using complex media has different drawbacks like higher costs for downstream processing and significant ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - November 21, 2022 Category: Biotechnology Authors: Svenja Battling, Johannes Pastoors, Alexander Deitert, Tobias G ötzen, Lukas Hartmann, Eliot Schröder, Stanislav Yordanov and Jochen Büchs Tags: Research Source Type: research
Nucleic acid direct delivery to fibroblasts: a review of nucleofection and applications
The fibroblast is one of the ideal target cell candidates for cell-based gene therapy approaches to promote tissue repair. Gene delivery to fibroblasts by viral transfection has been confirmed to have high tra... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - November 4, 2022 Category: Biotechnology Authors: Ranyue Ren, Jiachao Guo, Guangwu Liu, Hao Kang, Hans-G ünther Machens, Arndt F. Schilling, Alex Slobodianski and Ziyang Zhang Tags: Review Source Type: research
Label-free detection of leukemic myeloblasts in hyaluronic acid
Chronic myeloid leukemia is generally required bone marrow biopsy for diagnosis. Although examining peripheral blood is less invasive, it has not been fully validated as a routine diagnostic test due to subopt... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - November 1, 2022 Category: Biotechnology Authors: Suhyun Park, Hyueyun Kim, Minna Woo and Minsuk Kim Tags: Methodology Source Type: research
Synthesis and characterization of growth factor free nanoengineered bioactive scaffolds for bone tissue engineering
To address the obstacles that come with orthopedic surgery for biological graft tissues, including immune rejections, bacterial infections, and weak osseointegration, bioactive nanocomposites have been used as... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - October 17, 2022 Category: Biotechnology Authors: Fatemeh Abedi, Sevil Vaghefi Moghaddam, Parisa Ghandforoushan, Marziyeh Aghazadeh, Hafez Ebadi and Soodabeh Davaran Tags: Research Source Type: research
Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification
In this study, an ALA production strain of Escherichia coli was constructed by rational metabolic engi... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - October 13, 2022 Category: Biotechnology Authors: Changchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng and Shiyan Qiao Tags: Research Source Type: research
DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines
Electrical stimulation is a novel tool to promote the differentiation and proliferation of precursor cells. In this work we have studied the effects of direct current (DC) electrical stimulation on neuroblasto... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - October 13, 2022 Category: Biotechnology Authors: Daniel Mart ín, J. Bocio-Nuñez, Santiago F. Scagliusi, Pablo Pérez, Gloria Huertas, Alberto Yúfera, Mercè Giner and Paula Daza Tags: Research Source Type: research
