Systems metabolic engineering of Corynebacterium glutamicum for the bioproduction of biliverdin via protoporphyrin independent pathway
Biliverdin, a prospective recyclable antioxidant and one of the most important precursors for optogenetics, has received growing attention. Biliverdin is currently produced by oxidation of bilirubin from mamma... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 29, 2019 Category: Biotechnology Authors: Jiho Seok, Young Jin Ko, Myeong-Eun Lee, Jeong Eun Hyeon and Sung Ok Han Tags: Research Source Type: research
Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli
Gamma ( γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG)... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 21, 2019 Category: Biotechnology Authors: Haina Yuan, Hongbo Wang, Ozkan Fidan, Yong Qin, Gongnian Xiao and Jixun Zhan Tags: Research Source Type: research
Improved expansion of equine cord blood derived mesenchymal stromal cells by using microcarriers in stirred suspension bioreactors
Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based treatments can require cell numbers in the millions or billions, with conventional ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 21, 2019 Category: Biotechnology Authors: Erin L. Roberts, Tiffany Dang, Sarah I. M. Lepage, Amir Hamed Alizadeh, Tylor Walsh, Thomas G. Koch and Michael S. Kallos Tags: Research Source Type: research
Rational protein design of Bacillus sp. MN chitosanase for altered substrate binding and production of specific chitosan oligomers
Partially acetylated chito-oligosaccharides (paCOS) have a variety of potential applications in different fields, but to harness their benefits, pure paCOS or well-defined paCOS mixtures are essential. For exa... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 12, 2019 Category: Biotechnology Authors: David Gercke, Eva K. Regel, Ratna Singh and Bruno M. Moerschbacher Tags: Research Source Type: research
PAMAM/polyhedral nanogold-modified probes with DNAase catalysis for the amperometric electrochemical detection of metastasis-associated lung adenocarcinoma transcript 1
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non coding RNA (lncRNA) present in serum, is an important biomarker for detecting hepatocellular carcinoma (HCC). However, there are some... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 6, 2019 Category: Biotechnology Authors: Fei Liu, Tao Li, Liqun Zhang, Guiming Xiang, Dongneng Jiang, Dianji Tu, Linlin Liu, Yi Li, Chang Liu and Xiaoyun Pu Tags: Research Source Type: research
Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity
Various hepatic models mimicking liver lobules have been investigated to evaluate the potential hepatotoxic effects of chemicals and drugs, but in vitro hepatic models of zonal hepatotoxicity have not yet been... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 6, 2019 Category: Biotechnology Authors: Jaehwan Ahn, Jun-Ho Ahn, Seokjoo Yoon, Yoon Sung Nam, Mi-Young Son and Jung-Hwa Oh Tags: Research Source Type: research
A frame-shifted gene, which rescued its function by non-natural start codons and its application in constructing synthetic gene circuits
Frame-shifted genes results in non-functional peptides. Because of this complete loss of function, frame-shifted genes have never been used in constructing synthetic gene circuits. (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 1, 2019 Category: Biotechnology Authors: Kathakali Sarkar, Sayak Mukhopadhyay, Deepro Bonnerjee, Rajkamal Srivastava and Sangram Bagh Tags: Research Source Type: research
Protein-based vehicles for biomimetic RNAi delivery
Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemica... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 26, 2019 Category: Biotechnology Authors: Alex Eli Pottash, Christopher Kuffner, Madeleine Noonan-Shueh and Steven M. Jay Tags: Review Source Type: research
Polymer-based controlled-release fed-batch microtiter plate – diminishing the gap between early process development and production conditions
Fed-batch conditions are advantageous for industrial cultivations as they avoid unfavorable phenomena appearing in batch cultivations. Those are for example the formation of overflow metabolites, catabolite re... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 22, 2019 Category: Biotechnology Authors: T. Keil, B. Dittrich, C. Lattermann, T. Habicher and J. B üchs Tags: Research Source Type: research
Thematic series on emerging leaders in biological engineering: convergence and new directions
Over the past two decades, the biological engineering research community has increased its efforts to promote ‘Convergence’. Many research endeavors have thus involved the synergy of multiple perspectives and ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 21, 2019 Category: Biotechnology Authors: Raj R. Rao Tags: Editorial Source Type: research
Current trends in biomarker discovery and analysis tools for traumatic brain injury
Traumatic brain injury (TBI) affects 1.7 million people in the United States each year, causing lifelong functional deficits in cognition and behavior. The complex pathophysiology of neural injury is a primary... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 19, 2019 Category: Biotechnology Authors: Briana I. Martinez and Sarah E. Stabenfeldt Tags: Review Source Type: research
Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy
Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study a... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 19, 2019 Category: Biotechnology Authors: Eric Krueger and Angela C. Brown Tags: Review Source Type: research
Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human hear... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 13, 2019 Category: Biotechnology Authors: Mi-Ok Lee, Kwang Bo Jung, Seong-Jae Jo, Sung-Ae Hyun, Kyoung-Sik Moon, Joung-Wook Seo, Sang-Heon Kim and Mi-Young Son Tags: Research Source Type: research
Direct cell reprogramming for tissue engineering and regenerative medicine
Direct cell reprogramming, also called transdifferentiation, allows for the reprogramming of one somatic cell type directly into another, without the need to transition through an induced pluripotent state. Th... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 13, 2019 Category: Biotechnology Authors: Alexander Grath and Guohao Dai Tags: Review Source Type: research
A prototype RFID tag for detecting bumblebee visitations within fragmented landscapes
Detecting the arbitrary movements of fast-moving insects under field conditions is notoriously difficult because existing technologies are limited by issues of size, weight, range and cost. Here, we establish ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - February 7, 2019 Category: Biotechnology Authors: Sarah E. Barlow, Mark A. O ’Neill and Bruce M. Pavlik Tags: Letters to the Editor Source Type: research
