The use of a novel deer antler decellularized cartilage-derived matrix scaffold for repair of osteochondral defects
The physiologic regenerative capacity of cartilage is severely limited. Current studies on the repair of osteochondral defects (OCDs) have mainly focused on the regeneration of cartilage tissues. The antler ca... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - September 3, 2021 Category: Biotechnology Authors: Wenhui Chu, Gaowei Hu, Lin Peng, Wei Zhang and Zhe Ma Tags: Research Source Type: research
CRISPR/Cas9 mediated T7 RNA polymerase gene knock-in in E. coli BW25113 makes T7 expression system work efficiently
T7 Expression System is a common method of ensuring tight control and high-level induced expression. However, this system can only work in some bacterial strains in which the T7 RNA Polymerase gene resides in the... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 12, 2021 Category: Biotechnology Authors: Changchuan Ye, Xi Chen, Mengjie Yang, Xiangfang Zeng and Shiyan Qiao Tags: Research Source Type: research
Three-dimensional printed hydroxyapatite bone tissue engineering scaffold with antibacterial and osteogenic ability
The development of an effective scaffold for bone defect repair is an urgent clinical need. However, it is challenging to design a scaffold with efficient osteoinduction and antimicrobial activity for regenera... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 9, 2021 Category: Biotechnology Authors: Liu Zhongxing, Wu Shaohong, Li Jinlong, Zhang Limin, Wang Yuanzheng, Gao Haipeng and Cao Jian Tags: Research Source Type: research
Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo
Development of engineered non-pathogenic bacteria, capable of expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells. Herei... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 3, 2021 Category: Biotechnology Authors: Mitra Samadi, Keivan Majidzadeh-A, Malihe Salehi, Neda Jalili, Zeinab Noorinejad, Marjan Mosayebzadeh, Ahad Muhammadnejad, Azadeh Sharif khatibi, Shima Moradi-Kalbolandi and Leila Farahmand Tags: Research Source Type: research
Ridge preservation applying a novel hydrogel for early angiogenesis and osteogenesis evaluation: an experimental study in canine
Ridge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising g... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 21, 2021 Category: Biotechnology Authors: Shuai Yuan, Qingshu Li, Kaiwen Chen, Zhixiang Mu, Tao Chen, Huanan Wang and Ping Ji Tags: Research Source Type: research
Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (Bs... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 29, 2021 Category: Biotechnology Authors: Lin Yu, Nan Huang, Liangpeng Ge, Heng Sun, Yuna Fu, Chundong Liu and Jianhua Wang Tags: Research Source Type: research
Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Tetramycin is a 26-member tetraene antibiotic used in agriculture. It has two components, tetramycin A and tetramycin B. Tetramycin B is obtained by the hydroxylation of tetramycin A on C4. This reaction is ca... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 22, 2021 Category: Biotechnology Authors: Guang Chen, Mengqiu Wang, Xianpu Ni and Huanzhang Xia Tags: Research Source Type: research
Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide
Skin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatol... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 22, 2021 Category: Biotechnology Authors: Chuan Fu, Zhiping Qi, Chengliang Zhao, Weijian Kong, Hongru Li, Wenlai Guo and Xiaoyu Yang Tags: Research Source Type: research
In vitro recellularization of decellularized bovine carotid arteries using human endothelial colony forming cells
Many patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some patients no suitable replacements (i.e. autologous or prosthetic bypass grafts) are available. A... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - April 21, 2021 Category: Biotechnology Authors: Nicolai Seiffert, Peter Tang, Eriselda Keshi, Anja Reutzel-Selke, Simon Moosburner, Hannah Everwien, Dag Wulsten, Hendrik Napierala, Johann Pratschke, Igor M. Sauer, Karl H. Hillebrandt and Benjamin Struecker Tags: Research Source Type: research
Alginate-chitosan core-shell microcapsule cultures of hepatic cells in a small scale stirred bioreactor: impact of shear forces and microcapsule core composition
A small scale stirred bioreactor was designed and the effect of different agitation rates (30, 60 and 100 rpm) was investigated on HepG2 cells cultured in alginate-chitosan (AC) core-shell microcapsule in term... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - April 17, 2021 Category: Biotechnology Authors: Shahla Khodabakhshaghdam, Ali Baradar Khoshfetrat and Reza Rahbarghazi Tags: Research Source Type: research
Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy
Bioreactors are essential tools for the development of efficient and high-quality cell therapy products. However, their application is far from full potential, holding several challenges when reconciling the c... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - April 13, 2021 Category: Biotechnology Authors: Oscar Fabian Garcia-Aponte, Christoph Herwig and Bence Kozma Tags: Review Source Type: research
Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration
The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 22, 2021 Category: Biotechnology Authors: Yonghyun Gwon, Sunho Park, Woochan Kim, Taeseong Han, Hyoseong Kim and Jangho Kim Tags: Research Source Type: research
Signal amplification and optimization of riboswitch-based hybrid inputs by modular and titratable toehold switches
Synthetic biological circuits are widely utilized to control microbial cell functions. Natural and synthetic riboswitches are attractive sensor modules for use in synthetic biology applications. However, tunin... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 19, 2021 Category: Biotechnology Authors: Yunhee Hwang, Seong Gyeong Kim, Sungho Jang, Jongmin Kim and Gyoo Yeol Jung Tags: Research Source Type: research
Biotechnological Activities and Applications of Bacterial Pigments Violacein and Prodigiosin
In this review, we discuss violacein and prodigiosin, two chromogenic bacterial secondary metabolites that have diverse biological activities. Although both compounds were “discovered” more than seven decades ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 11, 2021 Category: Biotechnology Authors: Seong Yeol Choi, Sungbin Lim, Kyoung-hye Yoon, Jin I. Lee and Robert J. Mitchell Tags: Review Source Type: research
An efficient system for intestinal on-site butyrate production using novel microbiome-derived esterases
Short-chain fatty acids, especially butyrate, play beneficial roles in sustaining gastrointestinal health. However, due to limitations associated with direct consumption of butyrate, there has been interest in... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - March 6, 2021 Category: Biotechnology Authors: Dah Hyun Jung, Ji Hyun Yong, Wontae Hwang, Mi Young Yoon and Sang Sun Yoon Tags: Research Source Type: research
