Construction of an immunotoxin via site-specific conjugation of anti-Her2 IgG and engineered Pseudomonas exotoxin A
Immunotoxins consisting of a toxin from bacteria or plants and a targeting module have been developed as potent anti-cancer therapeutics. The majority of them, especially those in preclinical or clinical testi... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 21, 2019 Category: Biotechnology Authors: Byeong Sung Lee, Yumi Lee, Jisoo Park, Bo Seok Jeong, Migyeong Jo, Sang Taek Jung and Tae Hyeon Yoo Tags: Research Source Type: research
Functional cellulose-based hydrogels as extracellular matrices for tissue engineering
Cellulose-based hydrogels are immensely important for tissue engineering. In this review, we attempt to document the source, nature, and application of cellulose-based hydrogels as an extracellular matrix for ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 20, 2019 Category: Biotechnology Authors: Sayan Deb Dutta, Dinesh K. Patel and Ki-Taek Lim Tags: Review Source Type: research
Engineered mosaic protein polymers; a simple route to multifunctional biomaterials
Engineered living materials (ELMs) are an exciting new frontier, where living organisms create highly functional materials. In particular, protein ELMs have the advantage that their properties can be manipulat... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 18, 2019 Category: Biotechnology Authors: Daniel T. Peters, Helen Waller, Mark A. Birch and Jeremy H. Lakey Tags: Research Source Type: research
Rise of the killer plants: investigating the antimicrobial activity of Australian plants to enhance biofilter-mediated pathogen removal
Biofilters are soil-plant based passive stormwater treatment systems which demonstrate promising, although inconsistent, removal of faecal microorganisms. Antimicrobial-producing plants represent a safe, inexp... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 6, 2019 Category: Biotechnology Authors: P. Galbraith, R. Henry and D. T. McCarthy Tags: Research Source Type: research
Contribution of nonconsensus base pairs within ArsR binding sequences toward ArsR-DNA binding and arsenic-mediated transcriptional induction
A transcriptional reporter is the key component in bacterial biosensors which are employed to monitor the induction or repression of a reporter gene corresponding to environmental change. Interaction of a tran... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 6, 2019 Category: Biotechnology Authors: Xingjuan Chen, Xin Jiang, Cuijuan Tie, Jinnon Yoo, Yan Wang, Meiying Xu, Guoping Sun, Jun Guo and Xianqiang Li Tags: Research Source Type: research
Label-free and washing-free alkaline phosphatase assay using a personal glucose meter
We herein describe a personal glucose meter (PGM)-based method for a label-free and washing-free determination of alkaline phosphatase (ALP) activity, which relies on the cascade enzymatic reactions promoted b... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 4, 2019 Category: Biotechnology Authors: Jun Ki Ahn, Hyo Yong Kim, Chang Yeol Lee, Ki Soo Park and Hyun Gyu Park Tags: Letter to the Editor Source Type: research
Expression profile analysis of long non-coding RNA in skeletal muscle of osteoporosis by microarray and bioinformatics
Osteoporosis (OP) is a condition featured by bone mass loss and bone tissue microarchitectural alterations due to impaired tissue homeostasis favoring excessive bone resorption versus deposition. The trigger o... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 31, 2019 Category: Biotechnology Authors: Shaojin Liu, Hongxing Huang, Shuang Chai, Hewei Wei, Jiachun Huang and Lei Wan Tags: Research Source Type: research
Transplantation of CRISPRa system engineered IL10-overexpressing bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction in diabetic mice
Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential to treat myocardial infarction (MI). However, in patients with dia... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 30, 2019 Category: Biotechnology Authors: Xin Meng, Minjuan Zheng, Ming Yu, Wei Bai, Lei Zuo, Xin Bu, Yi Liu, Linying Xia, Jing Hu, Liwen Liu and Jianping Li Tags: Research Source Type: research
Mixture theory modeling for characterizing solute transport in breast tumor tissues
Tumor numerical models have been used to quantify solute transport with a single capillary embedded in an infinite tumor expanse, but measurements from different mammalian tumors suggest that a tissue containi... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 29, 2019 Category: Biotechnology Authors: Sreyashi Chakraborty, Alican Ozkan, Marissa Nichole Rylander, Wendy A. Woodward and Pavlos Vlachos Tags: Research Source Type: research
Long-term continuous treatment of non-sterile real hospital wastewater by Trametes versicolor
Hospital wastewater is commonly polluted with high loads of pharmaceutically active compounds, which pass through wastewater treatment plants (WWTPs) and end up in water bodies, posing ecological and health ri... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 29, 2019 Category: Biotechnology Authors: Josep Anton Mir-Tutusaus, Eloi Parlad é, Marta Villagrasa, Damià Barceló, Sara Rodríguez-Mozaz, Maira Martínez-Alonso, Núria Gaju, Montserrat Sarrà and Glòria Caminal Tags: Research Source Type: research
Quantum dot therapeutics: a new class of radical therapies
Traditional therapeutics and vaccines represent the bedrock of modern medicine, where isolated biochemical molecules or designed proteins have led to success in treating and preventing diseases. However, sever... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 29, 2019 Category: Biotechnology Authors: Max Levy, Partha P. Chowdhury and Prashant Nagpal Tags: Review Source Type: research
The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model
More than five million Americans suffer from heart valve disease annually, a condition that worsens cardiac function and gradually leads to heart failure if appropriate treatment is not performed on time. Curr... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 27, 2019 Category: Biotechnology Authors: Ngoc Thien Lam, Ishita Tandon and Kartik Balachandran Tags: Research Source Type: research
Non-canonical amino acid labeling in proteomics and biotechnology
Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synt... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 22, 2019 Category: Biotechnology Authors: Aya M. Saleh, Kristen M. Wilding, Sarah Calve, Bradley C. Bundy and Tamara L. Kinzer-Ursem Tags: Review Source Type: research
Elucidation of the biosynthesis pathway and heterologous construction of a sustainable route for producing umbelliferone
Coumarins play roles in many biological processes. Angelica decursiva is one of the major sources of coumarins in China. Due to increasing demand for coumarins in the marketplace, traditional extraction from plan... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 22, 2019 Category: Biotechnology Authors: Yucheng Zhao, Xiangyun Jian, Jialin Wu, Wanchun Huang, Chuanlong Huang, Jun Luo and Lingyi Kong Tags: Research Source Type: research
A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth
Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal plan... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 17, 2019 Category: Biotechnology Authors: Manuel Pinheiro, Xinhui Ma, Michael J. Fagan, Grant T. McIntyre, Ping Lin, Gautham Sivamurthy and Peter A. Mossey Tags: Methodology Source Type: research
