A novel computationally engineered collagenase reduces the force required for tooth extraction in an ex-situ porcine jaw model
The currently employed tooth extraction methods in dentistry involve mechanical disruption of the periodontal ligament fibers, leading to inevitable trauma to the bundle bone comprising the socket walls. In ou... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 17, 2023 Category: Biotechnology Authors: Tamar Ansbacher, Ran Tohar, Adi Cohen, Orel Cohen, Shifra Levartovsky, Adi Arieli, Shlomo Matalon, Daniel Z. Bar, Maayan Gal and Evgeny Weinberg Tags: Research Source Type: research
Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy
Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous application... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 11, 2023 Category: Biotechnology Authors: Vitali V. Maldonado, Neel H. Patel, Emma E. Smith, C. Lowry Barnes, Michael P. Gustafson, Raj R. Rao and Rebekah M. Samsonraj Tags: Review Source Type: research
Dual growth factor-modified microspheres nesting human-derived umbilical cord mesenchymal stem cells for bone regeneration
Modular tissue engineering (MTE) is a novel “bottom-up” approach that aims to mimic complex tissue microstructural features. The constructed micromodules are assembled into engineered biological tissues with r... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 10, 2023 Category: Biotechnology Authors: Wenzhi Song, Lanlan Zhao, Yuqi Gao, Chunyu Han, Shengrui Gao, Min Guo, Jianfei Bai, Liqiang Wang, Wanzhong Yin, Feng Wu and Peibiao Zhang Tags: Research Source Type: research
Sandwich-like electro-conductive polyurethane-based gelatin/soybean oil nanofibrous scaffolds with a targeted release of simvastatin for cardiac tissue engineering
Cardiac tissue engineering (CTE) is a promising way for the restoration of injured cardiac tissue in the healthcare system. The development of biodegradable scaffolds with appropriate chemical, electrical, mec... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 6, 2023 Category: Biotechnology Authors: Solmaz Saghebasl, Abbas Nobakht, Hesam Saghebasl, Sanya Hayati, Ozra Naturi and Reza Rahbarghazi Tags: Research Source Type: research
Breast cancer brain metastasis: from etiology to state-of-the-art modeling
Currently, breast carcinoma is the most common form of malignancy and the main cause of cancer mortality in women worldwide. The metastasis of cancer cells from the primary tumor site to other organs in the bo... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 29, 2023 Category: Biotechnology Authors: Mohammad Kamalabadi Farahani, Maliheh Gharibshahian, Alireza Rezvani and Ahmad Vaez Tags: Review Source Type: research
A streptavidin –biotin system combined with magnetic actuators for remote neuronal guidance
The ability to control neuronal mobility and organization is of great importance in developing neuronal interfaces and novel therapeutic approaches. An emerging promising method is the manipulation of neuronal... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 20, 2023 Category: Biotechnology Authors: Dafna Rivka Levenberg, Eli Varon, Ganit Indech, Tal Ben Uliel, Lidor Geri, Amos Sharoni and Orit Shefi Tags: Research Source Type: research
Advances in the application of Mxene nanoparticles in wound healing
Skin is the largest organ of the human body. It plays a vital role as the body ’s first barrier: stopping chemical, radiological damage and microbial invasion. The importance of skin to the human body can never... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 8, 2023 Category: Biotechnology Authors: Chengzhi Liang, Jing He, Yuan Cao, Guoming Liu, Chengdong Zhang, Zhiping Qi, Chuan Fu and Yanling Hu Tags: Review Source Type: research
Influence of shear force on ex vivo expansion of hematopoietic model cells in a stirred tank bioreactor
To evaluate shear stress influence on ex vivo expansion of hematopoietic cell lineages for clinical application, in this study, human pro-monocytic cell (namely U937 cell line) was selected as a hematopoietic ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 5, 2023 Category: Biotechnology Authors: Sofia Mohseni, Ali Baradar Khoshfetrat, Reza Rahbarghazi, Shahla Khodabakhshaghdam and Leila Shafiei Kaleybar Tags: Research Source Type: research
Culture of vibrating microtome tissue slices as a 3D model in biomedical research
The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the assumption that the structures under study will perform at the best in vitro if cultivated in an environment that is as s... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 1, 2023 Category: Biotechnology Authors: Fatina Siwczak, Charlotte Hiller, Helga Pfannkuche and Marlon R. Schneider Tags: Review Source Type: research
Development of a universal, oriented antibody immobilization method to functionalize vascular prostheses for enhanced endothelialization for potential clinical application
Thrombosis is a common cause of vascular prosthesis failure. Antibody coating of prostheses to capture circulating endothelial progenitor cells to aid endothelialization on the device surface appears a promisi... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 1, 2023 Category: Biotechnology Authors: Qiuwang Zhang, Sebastian Duncan, Daniel A. Szulc, Charles de Mestral and Michael JB Kutryk Tags: Research Source Type: research
Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach
The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physical stability and obtain pharmaceutical applications such as hydrogels... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 23, 2023 Category: Biotechnology Authors: Sergio A. Bernal-Ch ávez, Alejandra Romero-Montero, Héctor Hernández-Parra, Sheila I. Peña-Corona, María L. Del Prado-Audelo, Sergio Alcalá-Alcalá, Hernán Cortés, Lashyn Kiyekbayeva, Javad Sharifi-Rad and Gerardo Leyva-Gómez Tags: Review Source Type: research
A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines
Multiple myeloma (MM) is the second most common hematologic neoplasm which is characterized by proliferation and infiltration of plasmatic cells in the bone marrow. Currently, MM is considered incurable due to... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - May 4, 2023 Category: Biotechnology Authors: Josep Escriv á-Fernández, Cristina Cueto-Ureña, Amalia Solana-Orts, Elisa Lledó, Begoña Ballester-Lurbe and Enric Poch Tags: Methodology Source Type: research
Novel organoid construction strategy for non-involuting congenital hemangioma for drug validation
Non-involuting congenital hemangiomas (NICHs) are fully formed vascular tumors at birth with distinctive clinical, radiologic, and histopathological profiles. In the literature, there is no effective therapy s... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - April 27, 2023 Category: Biotechnology Authors: Haoche Wei, Yanan Li, Li Li, Qian Hu, Mingsong Shi, Linbo Cheng, Xile Jiang, Yanting Zhou, Siyuan Chen, Yi Ji and Lijuan Chen Tags: Research Source Type: research
Non-spherical gold nanoparticles enhanced fluorescence of carbon dots for norovirus-like particles detection
Norovirus is a common pathogen that causes foodborne outbreaks every year and the increasing number of deaths caused by it has become a substantial concern in both developed and underdeveloped countries. To da... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - April 27, 2023 Category: Biotechnology Authors: Abdulhakeem Alzahrani, Tawfiq Alsulami, Ahmad Mohammad Salamatullah and Syed Rahin Ahmed Tags: Methodology Source Type: research
Development of anti-aflatoxin B1 nanobodies from a novel mutagenesis-derived synthetic library for traditional Chinese medicine and foods safety testing
The main commercially available methods for detecting small molecules of mycotoxins in traditional Chinese medicine (TCM) and functional foods are enzyme-linked immunosorbent assay and mass spectrometry. Regar... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - April 24, 2023 Category: Biotechnology Authors: Yu-Ching Lee, Gar-Hwa Lai, Tsai-Yu Lin, Tien-Sheng Tseng, Tsung-Hsun Tsai, Wang-Chuan Chen, Cheng-Chung Lee and Keng-Chang Tsai Tags: Research Source Type: research
