Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2
MicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS) and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role in IS therapy. Herein we hypothesized that the B... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 28, 2019 Category: Biotechnology Authors: Yiming Deng, Duanduan Chen, Feng Gao, Hong Lv, Guojun Zhang, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Tianyi Yan, Jingbo Zhang and Zhongrong Miao Tags: Research Source Type: research
Using the promoters of MerR family proteins as “rheostats” to engineer whole-cell heavy metal biosensors with adjustable sensitivity
Whole cell biosensors provide a simple method for the detection of heavy metals. However, previous designs of them rely primarily on simulation of heavy metal resistance systems of bacteria. (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 20, 2019 Category: Biotechnology Authors: Mingzhang Guo, Ruoxi Du, Zixin Xie, Xiaoyun He, Kunlun Huang, Yunbo Luo and Wentao Xu Tags: Research Source Type: research
Targeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model
Non-alcoholic fatty liver disease (NAFLD) begins as simple hepatic steatosis, but further progress to chronic liver diseases results in severe liver damage and hepatic failure. However, therapeutic options are... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 8, 2019 Category: Biotechnology Authors: Jae-Sung Ryu, Minji Lee, Seon Ju Mun, Sin-Hyoung Hong, Ho-Joon Lee, Hyo-Suk Ahn, Kyung-Sook Chung, Gun-Hwa Kim and Myung Jin Son Tags: Research Source Type: research
The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate
Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 7, 2019 Category: Biotechnology Authors: Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosenbohm, Ruiguo Yang, Bin Duan and Jung Yul Lim Tags: Review Source Type: research
Discovery and engineering of an endophytic Pseudomonas strain from Taxus chinensis for efficient production of zeaxanthin diglucoside
Endophytic microorganisms are a rich source of bioactive natural products. They are considered as promising biofertilizers and biocontrol agents due to their growth-promoting interactions with the host plants ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 1, 2019 Category: Biotechnology Authors: Ozkan Fidan and Jixun Zhan Tags: Research Source Type: research
Neuromodulation of metabolic functions: from pharmaceuticals to bioelectronics to biocircuits
Neuromodulation of central and peripheral neural circuitry brings together neurobiologists and neural engineers to develop advanced neural interfaces to decode and recapitulate the information encoded in the n... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 1, 2019 Category: Biotechnology Authors: Benjamin J. Seicol, Sebastian Bejarano, Nicholas Behnke and Liang Guo Tags: Review Source Type: research
Modified substrate specificity of a methyltransferase domain by protein insertion into an adenylation domain of the bassianolide synthetase
Creating designer molecules using a combination of select domains from polyketide synthases and/or nonribosomal peptide synthetases (NRPS) continues to be a synthetic goal. However, an incomplete understanding... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 31, 2019 Category: Biotechnology Authors: Fuchao Xu, Russell Butler, Kyle May, Megi Rexhepaj, Dayu Yu, Jiachen Zi, Yi Chen, Yonghong Liang, Jia Zeng, Joan Hevel and Jixun Zhan Tags: Research Source Type: research
Performance evaluation of a hybrid sequencing batch reactor under saline and hyper saline conditions
Significant rise in concentration of saline wastewater entering the treatment plants has been resulting in many problems in the biological treatment processes. On the other hand, the specific conditions of phy... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 29, 2019 Category: Biotechnology Authors: Mostafa Tizghadam Ghazani and Alireza Taghdisian Tags: Research Source Type: research
The engineering principles of combining a transcriptional incoherent feedforward loop with negative feedback
Regulation of gene expression is of paramount importance in all living systems. In the past two decades, it has been discovered that certain motifs, such as the feedforward motif, are overrepresented in gene r... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 10, 2019 Category: Biotechnology Authors: Gregory T. Reeves Tags: Research Source Type: research
Characterization of covalent crosslinking strategies for synthesizing DNA-based bioconjugates
An adapted strategy from the conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) crosslinking method was developed to form a covalently coupled phosphoramidated single stranded DNA ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 10, 2019 Category: Biotechnology Authors: Malithi P. Wickramathilaka and Bernard Y. Tao Tags: Research Source Type: research
A silkworm based silk gland bioreactor for high-efficiency production of recombinant human lactoferrin with antibacterial and anti-inflammatory activities
Silk glands are used by silkworms to spin silk fibers for making their cocoons. These have recently been regarded as bioreactor hosts for the cost-effective production of other valuable exogenous proteins and ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 5, 2019 Category: Biotechnology Authors: Sheng Xu, Feng Wang, Yuancheng Wang, Riyuan Wang, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao and Qingyou Xia Tags: Research Source Type: research
Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6
As a type of chronic autoimmune joint disease, rheumatoid arthritis (RA) is a disorder, characterized by a variety of physical symptoms as well as RA fibroblast-like synoviocyte (RA-FLS) proliferation. More re... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 2, 2019 Category: Biotechnology Authors: Chun-Wang Zhang, Xia Wu, Dan Liu, Wei Zhou, Wei Tan, Yu-Xuan Fang, Yu Zhang, Yan-Qing Liu and Guo-Qing Li Tags: Research Source Type: research
Cardiac tissue engineering: state-of-the-art methods and outlook
The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Thos... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 28, 2019 Category: Biotechnology Authors: Anh H. Nguyen, Paul Marsh, Lauren Schmiess-Heine, Peter J. Burke, Abraham Lee, Juhyun Lee and Hung Cao Tags: Review Source Type: research
Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy
Traditional cancer therapies, such as surgery treatment, radiotherapy, and chemotherapy, often fail to completely eliminate tumor cells in an anaerobic microenvironment of tumor regions. (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 28, 2019 Category: Biotechnology Authors: Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu and Liqiu Xia Tags: Research Source Type: research
Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells
The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - June 28, 2019 Category: Biotechnology Authors: Roberto A Z úñiga, Matías Gutiérrez-González, Norberto Collazo, Pablo Hérnan Sotelo, Carolina H Ribeiro, Claudia Altamirano, Carmen Lorenzo, Juan Carlos Aguillón and María Carmen Molina Tags: Research Source Type: research
