Challenges of aortic valve tissue culture – maintenance of viability and extracellular matrix in the pulsatile dynamic microphysiological system
Calcific aortic valve disease (CAVD) causes an increasing health burden in the 21st century due to aging population. The complex pathophysiology remains to be understood to develop novel prevention and treatment ... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - September 28, 2023 Category: Biotechnology Authors: Claudia Dittfeld, Maximilian Winkelkotte, Anna Scheer, Emmely Voigt, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag and Sems-Malte Tugtekin Tags: Research Source Type: research
Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle
Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses. Streptococcus a... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - September 26, 2023 Category: Biotechnology Authors: Rajesh Kumar Pathak and Jun-Mo Kim Tags: Research Source Type: research
Efficient targeting of HIF-1 α mediated by YC-1 and PX-12 encapsulated niosomes: potential application in colon cancer therapy
A number of molecular biofactors have been documented in pathogenesis and poor prognosis of colorectal cancer (CRC). Among them, the Hypoxia-Inducible Factor (HIF-1a) is frequently reported to become over-expr... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - September 25, 2023 Category: Biotechnology Authors: Azar Bakand, Sevil Vaghefi Moghaddam, Maryam Naseroleslami, Helder Andr é, Neda Mousavi-Niri and Effat Alizadeh Tags: Research Source Type: research
Light regulation of secondary metabolism in fungi
Fungi have evolved unique metabolic regulation mechanisms for adapting to the changing environments. One of the key features of fungal adaptation is the production of secondary metabolites (SMs), which are ess... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 31, 2023 Category: Biotechnology Authors: Wenbin Yu, Rongqiang Pei, Yufei Zhang, Yayi Tu and Bin He Tags: Review Source Type: research
Recent advances in 3D printing of biodegradable metals for orthopaedic applications
The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field of biomedicine. Recent advancements in material technology have expanded the range of materials suitab... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 29, 2023 Category: Biotechnology Authors: Wenqing Liang, Chao Zhou, Hongwei Zhang, Juqin Bai, Bo Jiang, Chanyi Jiang, Wenyi Ming, Hengjian Zhang, Hengguo Long, Xiaogang Huang and Jiayi Zhao Tags: Review Source Type: research
Optimizing the fabrication of a 3D high-resolution implant for neural stimulation
Tissue-integrated micro-electronic devices for neural stimulation hold great potential in restoring the functionality of degenerated organs, specifically, retinal prostheses, which are aimed at vision restorat... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 24, 2023 Category: Biotechnology Authors: Gal Shpun, Nairouz Farah, Yoav Chemla, Amos Markus, Tamar Azrad Leibovitch, Erel Lasnoy, Doron Gerber, Zeev Zalevsky and Yossi Mandel Tags: Methodology Source Type: research
A novel inductively coupled capacitor wireless sensor system for rapid antibiotic susceptibility testing
The increasing prevalence and severity of antimicrobial resistance (AMR) present a major challenge to our healthcare system. Rapid detection of AMR is essential for lifesaving under emergent conditions such as... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 18, 2023 Category: Biotechnology Authors: Yikang Xu and Dacheng Ren Tags: Research Source Type: research
Cancer-on-chip: a 3D model for the study of the tumor microenvironment
The approval of anticancer therapeutic strategies is still slowed down by the lack of models able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro models fail to recapi... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 17, 2023 Category: Biotechnology Authors: Elisa Cauli, Michela Anna Polidoro, Simona Marzorati, Claudio Bernardi, Marco Rasponi and Ana Lleo Tags: Review Source Type: research
Tissue poromechanical deformation effects on steam pop likelihood in 3-D radiofrequency cardiac ablation
Radiofrequency Cardiac Ablation (RFCA) is a common procedure that heats cardiac tissue to destroy abnormal signal pathways to eliminate arrhythmias. The complex multiphysics phenomena during this procedure nee... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 7, 2023 Category: Biotechnology Authors: Patcharaporn Wongchadakul, Ashim K. Datta and Phadungsak Rattanadecho Tags: Research Source Type: research
Fluid dynamic design for mitigating undesired cell effects and its application to testis cell response testing to endocrine disruptors
Microfluidic devices have emerged as powerful tools for cell-based experiments, offering a controlled microenvironment that mimic the conditions within the body. Numerous cell experiment studies have successfu... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 7, 2023 Category: Biotechnology Authors: Seungjin Lee, Jinseop Ahn, Seok-Man Kim, Daehan Kim, Jiun Yeom, Jeongmok Kim, Joong Yull Park and Buom-Yong Ryu Tags: Research Source Type: research
Comparative transcriptome findings reveal the neuroinflammatory network and potential biomarkers to early detection of ischemic stroke
Ischemic stroke accounts for 70 –80% of all stroke cases, leading to over two million people dying every year. Poor diagnosis and late detection are the major causes of the high death and disability rate. (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - August 2, 2023 Category: Biotechnology Authors: Jiefeng Luo, Dingzhi Chen, Yujia Mei, Hepeng Li, Biyun Qin, Xiao Lin, Ting Fung Chan, Keng Po Lai and Deyan Kong Tags: Research Source Type: research
Non-viral gene delivery to human mesenchymal stem cells: a practical guide towards cell engineering
In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage multipotency, proliferative propertie... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 25, 2023 Category: Biotechnology Authors: Natalia Carballo-Pedrares, Federica Ponti, Junquera Lopez-Seijas, Diego Miranda-Balbuena, Nina Bono, Gabriele Candiani and Ana Rey-Rico Tags: Review Source Type: research
An injectable, self-healing, electroconductive hydrogel loaded with neural stem cells and donepezil for enhancing local therapy effect of spinal cord injury
Spinal cord injury (SCI) is a serious injury with high mortality and disability rates, and there is no effective treatment at present. It has been reported that some treatments, such as drug intervention and s... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 24, 2023 Category: Biotechnology Authors: Tiemei Liu, Qiang Zhang, Hongru Li, Xiaoqian Cui, Zhiping Qi and Xiaoyu Yang Tags: Research Source Type: research
PLGA/BGP/Nef porous composite restrains osteoclasts by inhibiting the NF- κB pathway, enhances IGF-1-mediated osteogenic differentiation and promotes bone regeneration
Novel bone substitutes are urgently needed in experimental research and clinical orthopaedic applications. There are many traditional Chinese medicines that have effects on bone repair. However, application of... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 17, 2023 Category: Biotechnology Authors: Feng Wu, Zhenxu Wu, Zhijun Ye, Guoqing Niu, Zhiliang Ma and Peibiao Zhang Tags: Research Source Type: research
Study of the regulatory elements of the Ovalbumin gene promoter using CRISPR technology in chicken cells
Hormone-dependent promoters are very efficient in transgene expression. Plasmid-based reporter assays have identified regulatory sequences of the Ovalbumin promoter that are involved in response to estrogen and h... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - July 17, 2023 Category: Biotechnology Authors: Sara Yousefi Taemeh, Nima Dehdilani, Lena Goshayeshi, Sylvie Rival-Gervier, Jalil Mehrzad, Bertrand Pain and Hesam Dehghani Tags: Research Source Type: research
