Human Endogenous Retrovirus-H and K Expression in Human Mesenchymal Stem Cells as Potential Markers of Stemness
Conclusions: Our findings showed that HERV-K and H were concurrently expressed with pluripotency biomarkers NANOG, OCT-4, and SOX-2.Intervirology (Source: Intervirology)
Source: Intervirology - May 17, 2019 Category: Virology Source Type: research
Molecular Basis for Arbovirus Transmission by < b > < i > Aedes aegypti < /i > < /b > Mosquitoes
Mosquitoes are considered the most important vectors for the transmission of pathogens to humans.Aedes aegypti is a unique species, not only by its highly anthropophilic and peridomestic habits but also because it can transmit an important variety of pathogenic viruses. Examples are dengue, yellow fever, chikungunya, Zika, and Mayaro viruses. After ingesting viremic blood, a wide range of mechanisms are activated in the mosquito to counteract viral infection. Nevertheless, these arboviruses possess strategies to overcome barriers in the mosquito and eventually reach the salivary glands to continue the transmission cycle. H...
Source: Intervirology - May 13, 2019 Category: Virology Source Type: research
Whole-Genome Sequencing and Genomic Analysis of a Virulent Bacteriophage Infecting < b > < i > Bacillus cereus < /i > < /b >
Conclusion: Because of characterization and genotyping of a new bacteriophage from soil samples containing earthworms, this study provides a baseline for the development of alternatives to antibiotics.Intervirology (Source: Intervirology)
Source: Intervirology - May 10, 2019 Category: Virology Source Type: research
Investigation of an Outbreak of Dengue Virus Serotype 1 in a Rural Area of Kribi, South Cameroon: A Cross-Sectional Study
Conclusion: The detection of DENV serotype 1 in an autochthonous population during this survey is a confirmation that the seaside city of Kribi is a risk area for contracting dengue infection in Cameroon.Intervirology (Source: Intervirology)
Source: Intervirology - May 5, 2019 Category: Virology Source Type: research
No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Na ïve HIV Patients
Conclusions: Injection drug use has little impact on TDR prevalence compared with other routes of transmission.Intervirology (Source: Intervirology)
Source: Intervirology - April 24, 2019 Category: Virology Source Type: research
Human Metapneumovirus: Laboratory Methods for Isolation, Propagation, and Plaque Titration
Conclusions: The isolation and propagation from patient-derived hMPV and the standardization of a practical, reliable, and inexpensive method of detection and quantification of hMPV were carried out, without the additional use of antibodies that had not been reported previously. These results offer some important insights for future studies of cellular and molecular biology of hMPV.Intervirology (Source: Intervirology)
Source: Intervirology - March 31, 2019 Category: Virology Source Type: research
Human Papillomavirus in Thai Women and Men with Anogenital Warts
Conclusion: Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.Intervirology (Source: Intervirology)
Source: Intervirology - March 22, 2019 Category: Virology Source Type: research
Analysis of Protein Expression in Human Cells Cocultured with Porcine Peripheral Blood Mononuclear Cells
Conclusion: The results of this study revealed differentially expressed proteins in HEK293 cells cocultured with porcine PBMCs and implied that these changes were probably induced by PERV infection. These results provide clues and potential links to understanding the molecular effect of the infection by human-tropic PERV.Intervirology (Source: Intervirology)
Source: Intervirology - March 20, 2019 Category: Virology Source Type: research
Evaluation of Acquired HIV Drug Resistance among People Living with HIV Who Have Taken Antiretroviral Therapy for 9 –15 Months in 14 Triangular Clinics in Iran, 2015–2016
Conclusions: This is the first study to illuminate the emergence of the CPX genotype among Iranian patients. The drug resistance rate of NNRTIs was similar to that of NRTIs. By assessing drug resistance, it is possible to evaluate the efficacy of treatment and patient adherence to treatment.Intervirology (Source: Intervirology)
Source: Intervirology - March 15, 2019 Category: Virology Source Type: research
Iterative Excretion of Human Cosaviruses from Different Genotypes Associated with Combined Immunodeficiency Disorder
Conclusions: This study describes excretion kinetics and genetic characteristics of HCoSVs in a patient with combined immunodeficiency due to MHC class II expression defect. The patient did not have concomitant symptoms related to the HCoSV infection.Intervirology (Source: Intervirology)
Source: Intervirology - February 6, 2019 Category: Virology Source Type: research
Development of a SYBR Green II Real-Time Polymerase Chain Reaction for the Clinical Detection of the Duck-Origin Goose Parvovirus in China
Conclusion: This test provides improved technical support for studies regarding the clinical diagnosis and epidemiological investigations of the duck-origin goose parvovirus.Intervirology (Source: Intervirology)
Source: Intervirology - January 17, 2019 Category: Virology Source Type: research
Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins
Conclusion: Overall, initial evidence is provided on the antiviral activity of several peptides, as well as of their derivatives. Further investigation is warranted to ascertain the mechanism of action in order to develop new potential antiviral drugs.Intervirology (Source: Intervirology)
Source: Intervirology - January 17, 2019 Category: Virology Source Type: research
The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication
Conclusions: The aa 421 –649 helper domain of HPV16 E1 includes the ATP-binding/helicase region of E1 which boosts rAAV production and has homology with the analogous region of parvovirus NS-1/Rep78 by NCBI protein BLAST, suggesting these biochemistries are responsible for the mechanism of action in E1 helper function.Intervirology (Source: Intervirology)
Source: Intervirology - January 17, 2019 Category: Virology Source Type: research
Viral Exploration of Negative Acute Febrile Cases Observed during Chikungunya Outbreaks in Gabon
Non-malarial febrile illness outbreaks were documented in 2007 and 2010 in Gabon. After investigation, these outbreaks were attributed to the chikungunya and dengue viruses (CHIKV and DENV). However, for more than half of the samples analyzed, the causative agent was not identified. Given the geographical and ecological position of Gabon, where there is a great animal and microbial diversity, the circulation of other emerging viruses was suspected in these samples lacking aetiology. A total of 436 undiagnosed samples, collected between 2007 and 2013, and originating from 14 urban, suburban, and rural Gabonese locations wer...
Source: Intervirology - January 13, 2019 Category: Virology Source Type: research
Loss of Transfected Human Brain Micro-Vascular Endothelial Cell Integrity during Herpes Simplex Virus Infection
Conclusion: This study shows for the first time that destruction of human brain micro-vascular endothelial cells as an in vitro model of the blood-brain barrier could be an alternative invasion mechanism during herpes simplex virus infection.Intervirology (Source: Intervirology)
Source: Intervirology - December 13, 2018 Category: Virology Source Type: research
