Havachoobe ( < b > < i > Onosma dichroanthum Boiss < /i > < /b > ) Root Extract Decreases the Hepatitis B Virus Surface Antigen Secretion in the PLC/PRF/5 Cell Line
In this study, we first reported anti-HBsAg activity on an Iranian herbal medicine. Havachoobe root extract was shown to be able to inhibit HBsAg in a dose-dependent and time-dependent manner. We find the extract exerts its inhibitory effect of HBsAg by targeting transcription of HBsAg.Intervirology (Source: Intervirology)
Source: Intervirology - December 15, 2020 Category: Virology Source Type: research
Contents Vol. 63, 2020
Intervirology 2020;63:I –II (Source: Intervirology)
Source: Intervirology - December 15, 2020 Category: Virology Source Type: research
Available Antiretrovirals in the Treatment and Pre-Exposure Prophylaxis of SARS-CoV-2: Quo Vadis?
Intervirology (Source: Intervirology)
Source: Intervirology - December 11, 2020 Category: Virology Source Type: research
Association of Sex, Age, and Comorbidities with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis
Conclusion: Implementation of adequate protection and interventions for COVID-19 patients in general and in particular male patients with age ≥50 years having comorbidities may significantly reduce risk of mortality associated with COVID-19.Intervirology (Source: Intervirology)
Source: Intervirology - December 9, 2020 Category: Virology Source Type: research
Publisher's Note
Intervirology (Source: Intervirology)
Source: Intervirology - December 3, 2020 Category: Virology Source Type: research
Historical Discoveries on Viruses in the Environment and Their Impact on Public Health
Background: Transmission of many viruses occurs by direct transmission during a close contact between two hosts, or by an indirect transmission through the environment. Several and often interconnected factors, both abiotic and biotic, determine the persistence of these viruses released in the environment, which can last from a few seconds to several years. Moreover, viruses in the environment are able to travel short to very long distances, especially in the air or in water.Summary: Although well described now, the role of these environments as intermediaries or as reservoirs in virus transmission has been extensively stu...
Source: Intervirology - November 25, 2020 Category: Virology Source Type: research
The Role of Autophagy-Mediated Dengue Virus Antibody-Dependent Enhancement Infection of THP-1 Cells
Conclusion: In the present study, an additional mechanism of autophagy was inhibited by the autophagy inhibitor (3-MA) in DENV- and DENV-ADE-infected THP-1 cells. Our finding provided a clear link between autophagy and antibody-enhanced infection of DENV.Intervirology (Source: Intervirology)
Source: Intervirology - November 17, 2020 Category: Virology Source Type: research
Understanding Severe Acute Respiratory Syndrome Coronavirus 2 Replication to Design Efficient Drug Combination Therapies
Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease CO VID-19 has strongly encouraged the search for antiviral compounds. Most of the evaluated drugs against SARS-CoV-2 derive from drug repurposing of Food and Drug Administration-approved molecules. These drugs have as target three major processes: (1) early stages of virus-cell interaction, (2) viral proteases, and (3) the viral RNA-dependent RNA polymerase.Summary: This review focused on the basic principles of virology and pharmacology to understand the importance of early stages of virus-cell interaction as therap...
Source: Intervirology - October 23, 2020 Category: Virology Source Type: research
A Comprehensive Study of Dengue Epidemics and Persistence of Anti-Dengue Virus Antibodies in District Swat, Pakistan
Conclusion: To sum up, male gender, young individuals, and those living in urban areas were at the greater risk of dengue infection.Intervirology (Source: Intervirology)
Source: Intervirology - October 13, 2020 Category: Virology Source Type: research
Proposed Algorithm for Hepatitis E Virus Diagnosis in the Early Phase of Illness
Hepatitis E virus (HEV), a major etiologic agent of enterically transmitted hepatitis worldwide, is known to cause outbreaks. Diagnosis of the causative agent is important for patient management, understanding epidemiology and outbreak mitigation. We attempted to develop an algorithm for molecular diagnosis and compared the diagnostic accuracy of 2 of HEV IgM ELISA tests during an outbreak. Eighty-four blood samples collected during an outbreak in central India were referred to a nodal laboratory for confirmation of diagnosis. The samples were tested by serological and molecular testes. The results were analyzed by statist...
Source: Intervirology - October 6, 2020 Category: Virology Source Type: research
Clinical, Virological, and Immunological Profiles of DENV, ZIKV, and/or CHIKV-Infected Brazilian Patients
Conclusions: From all the circulating mediators measured, we detected differences of IL-10, TNF- α, and CCL2/MCP-1 between arbovirus groups. We hypothesize that CXC10/IP-10, CCL2/MCP-1, and MIF in the CHIKV-infected group could regulate the CHIKV viral load, while CXC10/IP-10, CCL2/MCP-1, and TNF-α in DENV/ZIKV, and CHIKV/ZIKV groups, could regulate ZIKV viral load.Intervirology (Source: Intervirology)
Source: Intervirology - September 23, 2020 Category: Virology Source Type: research
Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study
This study was planned to investigate the association betweenhuman cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study.Summary: A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only c...
Source: Intervirology - August 7, 2020 Category: Virology Source Type: research
Contents
Intervirology 2019;62:I –IV (Source: Intervirology)
Source: Intervirology - July 23, 2020 Category: Virology Source Type: research
Sequence Similarities between Viroids and Human MicroRNAs
Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RNA interference. We looked for sequence similarities between viroids and the seed region of human microRNAs (hsa-miRNAs). Viroid genomes were retrieved from GenBank and mature hsa-mi RNAs were retrieved from miRBase. Two hundred 300-nucleotide-long sequences were randomly generated as controls. BLAST searches...
Source: Intervirology - July 8, 2020 Category: Virology Source Type: research
Prevalence of Anti-JC Virus Antibody Seropositivity in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis
Conclusion: The prevalence of anti-JCV antibody seropositivity is variable among MS patients in different countries, and the pooled estimate showed that this is 60% overall.Intervirology (Source: Intervirology)
Source: Intervirology - July 3, 2020 Category: Virology Source Type: research
