JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report
Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, althou...
Source: Intervirology - November 24, 2015 Category: Virology Source Type: research
Erratum
Intervirology 2015;58:270 (Source: Intervirology)
Source: Intervirology - November 12, 2015 Category: Virology Source Type: research
Prevalence of Human Cytomegalovirus and Epstein-Barr Virus in Chronic Periapical Lesions
Conclusion: Detection of HCMV and EBV in the samples of periapical lesions suggests an important role of herpesviruses in periapical tissue destruction.Intervirology 2015;58:271-277 (Source: Intervirology)
Source: Intervirology - November 9, 2015 Category: Virology Source Type: research
The Structure, Pathogenicity and Immunogenicity of Two Virion Fractions Harvested from Cell Cultures Infected with the CA16 Virus
Conclusions: The two CA16 virion fractions showed antigenicity and immunogenicity with inducing a specific immune response in animals.Intervirology 2015;58:260-269 (Source: Intervirology)
Source: Intervirology - October 31, 2015 Category: Virology Source Type: research
Dengue Virus Serotype-2 Interferes with the Formation of Neutrophil Extracellular Traps
Conclusion: Our results suggest that DENV-2 inhibits glucose uptake as a metabolism-based way to avoid the formation of NETs.Intervirology 2015;58:250-259 (Source: Intervirology)
Source: Intervirology - October 25, 2015 Category: Virology Source Type: research
Treatment of Acute Hepatitis C Infection with Pegylated Interferon and Ribavirin in Patients Coinfected with Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis
Conclusion: Peginterferon with ribavirin is an effective option for treating acute HCV in HIV-positive patients, especially if they achieve an RVR or an EVR.Intervirology 2015;58:242-249 (Source: Intervirology)
Source: Intervirology - September 25, 2015 Category: Virology Source Type: research
Immune Reactivity of Synthetic Peptides Originated from Hypervariable Region 1 of Hepatitis C Synthetic Consensuses with Egyptian Sera Infected with Hepatitis C Virus Type 4
We have studied the immune reactivity of hypervariable region 1 (HVR1) of hepatitis C virus (HCV) against HCV immune positive and negative sera. Two published HVR1 consensus nucleotide sequences (Italian and Chinese) were synthesized, and with both of them, a splicing by overlap extension polymerase chain reaction, cloning and sequencing were performed. From the corresponding amino acid sequences, 3 Italian and 1 Chinese HVR1 peptides were selected for synthesis. The 4 peptides (MB1-MB4; GenBank No.: HQ846888-HQ846891) were used to screen 47 and 31 HCV (type 4) immune positive and negative sera, respectively, by enzyme-lin...
Source: Intervirology - September 2, 2015 Category: Virology Source Type: research
Isolation and Characterization of Lytic Phage vB_EcoM_JS09 against Clinically Isolated Antibiotic-Resistant Avian Pathogenic Escherichia coli and Enterotoxigenic Escherichia coli
Conclusions: A novel lytic coliphage named JS09 was isolated from sewage samples of a swine farm in Jiangsu Province, China. It could infect antibiotic-resistant APEC and ETEC. The morphological, genomic, and growth characteristics of JS09 were studied, and this will be helpful for phage therapy in controlling diseases caused by APEC and ETEC.Intervirology 2015;58:218-231 (Source: Intervirology)
Source: Intervirology - August 24, 2015 Category: Virology Source Type: research
4EBP1 Is Dephosphorylated by Respiratory Syncytial Virus Infection
Respiratory syncytial virus (RSV) requires protein biosynthesis machinery to generate progeny. There is evidence that RSV might alter some translation components since stress granules are formed in their host cells. Consistent with these observations, we found that RSV induces dephosphorylation of 4EBP1 (eIF4E-binding protein), an important cellular translation factor. Our results show no correlation between the 4EBP1 dephosphorylation time and the decrease in the global rate of protein synthesis. Interestingly, treatment with rapamycin stimulates virus generation. The results suggest that RSV is a virus that still contain...
Source: Intervirology - August 21, 2015 Category: Virology Source Type: research
One of the Mechanisms to Increase HSV-1 Uptake in HSV-1-Infected, Activated T Lymphocytes Is the Formation of Filopodia
Conclusions: High expressions of viral receptor protein and filopodia formations are the key factors that enhance the HSV-1 entry into activated T lymphocytes, resulting in an increased production of the virus.Intervirology 2015;58:209-217 (Source: Intervirology)
Source: Intervirology - August 21, 2015 Category: Virology Source Type: research
Partial Sequence of a Novel Virus Isolated from Pelodiscus sinensis Hemorrhagic Disease
Outbreaks of hemorrhagic syndrome-like disease with high mortality rates have frequently occurred in Pelodiscus sinensis farms. The purpose of this study was to investigate the pathogen through challenge infection assays and partial sequencing of the genome of the pathogen. A 453-bp amplicon was obtained by random PCR using the nucleic acid extracted from the tissue homogenate filtrate and showed 32% identity at the amino acid level with the replicase polyprotein of the porcine reproductive and respiratory syndrome virus by Blastx. Multiple alignments indicated the putative protein sequence has some similarities to the rep...
Source: Intervirology - August 6, 2015 Category: Virology Source Type: research
Development of Protective Immunity against Inactivated Iranian Isolate of Foot-and-Mouth Disease Virus Type O/IRN/2007 Using Gamma Ray-Irradiated Vaccine on BALB/c Mice and Guinea Pigs
Conclusion: GRI vaccine is suitable for both routine vaccination and control of FMDV in emergency outbreaks.Intervirology 2015;58:190-196 (Source: Intervirology)
Source: Intervirology - July 23, 2015 Category: Virology Source Type: research
Proviral DNA as a Target for HIV-1 Resistance Analysis
Conclusions: Proviral DNA resistance testing provides additional resistance information for TN patients. It is also a reliable alternative for TE patients with unsuccessful RNA testing and can provide valuable information when no records are available.Intervirology 2015;58:184-189 (Source: Intervirology)
Source: Intervirology - June 27, 2015 Category: Virology Source Type: research
Early Evolution of Human Respiratory Syncytial Virus ON1 Strains: Analysis of the Diversity in the C-Terminal Hypervariable Region of Glycoprotein Gene within the First 3.5 Years since Their Detection
Conclusions: The fast spread of the novel HRSV genotype ON1 has been accompanied by its rapid concurrent diversification. Differences in variability of the two replicas within HVR2 were detected, with C-terminal replica being more variable.Intervirology 2015;58:172-180 (Source: Intervirology)
Source: Intervirology - June 19, 2015 Category: Virology Source Type: research
Characterization of the Genotypic Profile of Hepatitis Delta Virus: Isolation of HDV Genotype-1 in the Western Amazon Region of Brazil
Conclusion: To date, this is the most extensive clinical study of HDV-1 genotype infections in the nonindigenous population of Western Amazonia.Intervirology 2015;58:166-171 (Source: Intervirology)
Source: Intervirology - June 19, 2015 Category: Virology Source Type: research
